纳米光疗:癌症治疗的良好前景。

J P Jose Merlin, Anine Crous, Heidi Abrahamse
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引用次数: 0

摘要

基于纳米技术的光疗法在对抗癌症方面引起了人们的兴趣,因为它在癌症靶向和基于其表面性质和大小的药物递送方面具有非侵袭性、高灵活性和精确性。近几十年来,光疗取得了显著的发展。利用纳米材料或纳米技术的光疗方法已经出现,有助于医学中纳米技术的进步,特别是癌症。简要综述了光动力疗法的发展及其在癌症治疗中的作用机制。我们强调了用于光动力治疗的新型纳米颗粒的设计,同时总结了近年来的代表性进展。最后,为了预测该领域未来的重要研究,我们考察了基于纳米颗粒的光动力治疗系统在临床抗癌治疗应用中的可行性和前景,并简要提到了消除生物体内与纳米制剂有关的所有反应性代谢产物,从而深入了解临床机制过程。对光动力治疗的未来发展和治疗前景进行了展望。我们的观点可能会鼓励科学家创造更有效的基于光疗法的癌症治疗模式。这篇文章分类在:治疗方法和药物发现>肿瘤疾病的纳米医学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nano-phototherapy: Favorable prospects for cancer treatment.

Nanotechnology-based phototherapies have drawn interest in the fight against cancer because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting and drug delivery based on its surface properties and size. Phototherapy has made remarkable development in recent decades. Approaches to phototherapy, which utilize nanomaterials or nanotechnology have emerged to contribute to advances around nanotechnologies in medicine, particularly for cancers. A brief overviews of the development of photodynamic therapy as well as its mechanism in cancer treatment is provided. We emphasize the design of novel nanoparticles utilized in photodynamic therapy while summarizing the representative progress during the recent years. Finally, to forecast important future research in this area, we examine the viability and promise of photodynamic therapy systems based on nanoparticles in clinical anticancer treatment applications and briefly make mention of the elimination of all reactive metabolites pertaining to nano formulations inside living organisms providing insight into clinical mechanistic processes. Future developments and therapeutic prospects for photodynamic treatments are anticipated. Our viewpoints might encourage scientists to create more potent phototherapy-based cancer therapeutic modalities. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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