FSTL3、ADAM12和FAT4对癌症患者预后的影响:临床病理研究。

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY Applied Immunohistochemistry & Molecular Morphology Pub Date : 2023-11-01 Epub Date: 2023-09-26 DOI:10.1097/PAI.0000000000001157
Hanaa M Ibrahim, Aziza E Abdelrahman, Amira Elwan, Adel Bakry, Moamna M Fahmy, Mohamed I Abdelhamid, Abdelfatah H Abdelwanis, Enas M Fouad
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Positive ADAM12 expression was observed in 60% and significantly related to left-sided tumors ( P = 0.001) and significantly common in high grade ( P = 0.028), lymph node involvement ( P < 0.001), and advanced stage ( P = 0.004). Low FAT4 expression was recognized in 76% and linked with the right-sided tumors ( P = 0.036). FAT4 expression was contrariwise linked with CC grade ( P < 0.001). Furthermore, FAT4 expression was inversely correlated with lymph node involvement ( P = 0.002), metastasis ( P = 0.046), and advanced stage ( P = 0.002). During the follow-up, 14 cases were relapsed and positively associated with high FSTL3 expression ( P = 0.001) and ADAM12 expression ( P < 0.001), but negatively linked with FAT4 expression ( P = 0.003). Shorter disease-free survival was substantially correlated with positive ADAM12, extreme FSTL3, and low FAT4 expression ( P < 0.001, P = 0.002, P = 0.003, consecutively). 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引用次数: 0

摘要

在结肠癌癌症(CC)中,Wnt/β-catenin和Hippo/Yes-related蛋白1信号通路之间存在细胞串扰,这促进了介导CC转移进展的EMT过程。我们旨在评估CC中卵泡抑素样3(FSTL3)、ADAM12和FAT4的表达,和复发都起到了预后作用。68%的CC中检测到高FSTL3,与左侧肿瘤(P=0.002)和晚期肿瘤特征显著相关,如转移(P=0.010)、pT(P=0.006)、高分级(P=0.005)、淋巴结贡献(P=0.013),ADAM12阳性表达在60%中观察到并且与左侧肿瘤显著相关(P=0.001),和晚期(P=0.004)。76%的患者发现FAT4低表达,并与右侧肿瘤有关(P=0.036)。FAT4表达与CC分级呈负相关(P<0.001)。此外,FAT4的表达与淋巴结受累(P=0.002)、转移(P=0.046)和晚期(P=0.002)呈负相关。在随访期间,14例复发,与高FSTL3表达(P=0.001)和ADAM12表达(P<0.001)呈正相关,但与FAT4表达呈负相关(P=0.003)。较短的无病生存期与阳性ADAM12、极端FSTL3和低FAT4表达显著相关(P<0.001,P=0.002,P=0.003,连续)。此外,Kaplan-Meier曲线显示了具有极端FSTL3、阳性ADAM12和低FAT4的较短OS之间的显著相关性(P=0.004,
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Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.

There is a cellular crosstalk between Wnt/β-catenin and Hippo/Yes-related protein 1 signaling paths in colon cancer (CC) which promotes EMT processes that mediate the metastatic progression of CC. We aimed to evaluate follistatin-like 3 (FSTL3), ADAM12, and FAT4 expressions in CC. A statistical analysis was done to establish how disease-free survival, overall survival (OS), and relapse all performed a prognostic role. High FSTL3 was detected in 68% of CC and significantly related to left-sided tumors ( P = 0.002) and the advanced tumor features, such as metastasis ( P = 0.010), pT ( P = 0.006), high grade ( P = 0.005), lymph node contribution ( P = 0.013), and advanced stage ( P = 0.003). Positive ADAM12 expression was observed in 60% and significantly related to left-sided tumors ( P = 0.001) and significantly common in high grade ( P = 0.028), lymph node involvement ( P < 0.001), and advanced stage ( P = 0.004). Low FAT4 expression was recognized in 76% and linked with the right-sided tumors ( P = 0.036). FAT4 expression was contrariwise linked with CC grade ( P < 0.001). Furthermore, FAT4 expression was inversely correlated with lymph node involvement ( P = 0.002), metastasis ( P = 0.046), and advanced stage ( P = 0.002). During the follow-up, 14 cases were relapsed and positively associated with high FSTL3 expression ( P = 0.001) and ADAM12 expression ( P < 0.001), but negatively linked with FAT4 expression ( P = 0.003). Shorter disease-free survival was substantially correlated with positive ADAM12, extreme FSTL3, and low FAT4 expression ( P < 0.001, P = 0.002, P = 0.003, consecutively). Moreover, Kaplan-Meier curves demonstrated a significant correlation between shorter OS with extreme FSTL3, positive ADAM12, and low FAT4 ( P = 0.004, <0.001, 0.019, consecutively). High FSTL3, positive ADAM12, and low FAT4 expression are unfavorable prognostic influences in CC that may be accountable for relapse and therapeutic resistance in CC.

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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
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