Carmelo M Vicario, Stergios Makris, Laura Culicetto, Chiara Lucifora, Alessandra Falzone, Gabriella Martino, Francesca Ferraioli, Michael A Nitsche, Alessio Avenanti, Giuseppe Craparo
{"title":"新冠肺炎大流行期间疫苗犹豫程度高的个体恐惧消失学习改变的证据。","authors":"Carmelo M Vicario, Stergios Makris, Laura Culicetto, Chiara Lucifora, Alessandra Falzone, Gabriella Martino, Francesca Ferraioli, Michael A Nitsche, Alessio Avenanti, Giuseppe Craparo","doi":"10.36131/cnfioritieditore20230417","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>A relevance of fear and concerns about vaccine development and its side effects are suggested to explain COVID-19 vaccine hesitancy. However, evidence supporting the phobic origin hypothesis of hesitancy for COVID-19 and other vaccinations remains indirect and elusive.</p><p><strong>Method: </strong>We addressed this issue by investigating the existence of a relationship between fear conditioning, extinction, and the respective vaccination hesitancy and anxiety scores in a group of 25 individuals.</p><p><strong>Results: </strong>Overall, we show that the general mechanism of fear extinction learning is impaired in individuals with high vaccine hesitancy. State and trait anxiety scores do not account for this result.</p><p><strong>Conclusions: </strong>These findings suggest that attitudes against vaccination could be linked to an altered inhibitory learning process.</p>","PeriodicalId":46700,"journal":{"name":"Clinical Neuropsychiatry","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544234/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evidence of Altered Fear Extinction Learning in Individuals with High Vaccine Hesitancy During Covid-19 Pandemic.\",\"authors\":\"Carmelo M Vicario, Stergios Makris, Laura Culicetto, Chiara Lucifora, Alessandra Falzone, Gabriella Martino, Francesca Ferraioli, Michael A Nitsche, Alessio Avenanti, Giuseppe Craparo\",\"doi\":\"10.36131/cnfioritieditore20230417\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>A relevance of fear and concerns about vaccine development and its side effects are suggested to explain COVID-19 vaccine hesitancy. However, evidence supporting the phobic origin hypothesis of hesitancy for COVID-19 and other vaccinations remains indirect and elusive.</p><p><strong>Method: </strong>We addressed this issue by investigating the existence of a relationship between fear conditioning, extinction, and the respective vaccination hesitancy and anxiety scores in a group of 25 individuals.</p><p><strong>Results: </strong>Overall, we show that the general mechanism of fear extinction learning is impaired in individuals with high vaccine hesitancy. State and trait anxiety scores do not account for this result.</p><p><strong>Conclusions: </strong>These findings suggest that attitudes against vaccination could be linked to an altered inhibitory learning process.</p>\",\"PeriodicalId\":46700,\"journal\":{\"name\":\"Clinical Neuropsychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544234/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neuropsychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36131/cnfioritieditore20230417\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neuropsychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36131/cnfioritieditore20230417","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Evidence of Altered Fear Extinction Learning in Individuals with High Vaccine Hesitancy During Covid-19 Pandemic.
Objective: A relevance of fear and concerns about vaccine development and its side effects are suggested to explain COVID-19 vaccine hesitancy. However, evidence supporting the phobic origin hypothesis of hesitancy for COVID-19 and other vaccinations remains indirect and elusive.
Method: We addressed this issue by investigating the existence of a relationship between fear conditioning, extinction, and the respective vaccination hesitancy and anxiety scores in a group of 25 individuals.
Results: Overall, we show that the general mechanism of fear extinction learning is impaired in individuals with high vaccine hesitancy. State and trait anxiety scores do not account for this result.
Conclusions: These findings suggest that attitudes against vaccination could be linked to an altered inhibitory learning process.
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