使用ChatGPT预测个性化医疗的未来。

IF 2.9 3区 医学 Q2 GENETICS & HEREDITY Pharmacogenomics Journal Pub Date : 2023-09-19 DOI:10.1038/s41397-023-00316-9
George P. Patrinos, Negar Sarhangi, Behnaz Sarrami, Nazli Khodayari, Bagher Larijani, Mandana Hasanzad
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引用次数: 0

摘要

个性化医疗是基于每个人独特基因构成的医疗保健领域的一个新前沿。这是一个令人兴奋的机会,可以改善所有人的个性化医疗保健的未来。药物基因组学作为个性化医学的主要组成部分,旨在根据药物反应的基因变异优化和创造一种更有针对性的治疗方法。据预测,未来的治疗将基于算法,而不是基于证据,考虑患者的遗传、转录组学、蛋白质组学、表观遗传学和生活方式因素,从而实现个性化用药。生成预训练转换器(GPT)是一种人工智能(AI)工具,它生成类似人类写作的语言,使用户能够以与人类对话几乎相同的方式参与其中。GPT的预测算法可以回答从未解决过的问题。Chat Generative Pretrained Transformer(ChatGPT)是一款具有会话功能的人工智能聊天机器人。在本研究中,ChatGPT就个性化医学和药物基因组学的未来提出了问题。ChatGPT预测,这两种方法都是一种前景光明的方法,在改善患者预后和改变医学领域方面前景广阔。但它仍有一些局限性需要解决。
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Using ChatGPT to predict the future of personalized medicine
Personalized medicine is a novel frontier in health care that is based on each person’s unique genetic makeup. It represents an exciting opportunity to improve the future of individualized health care for all individuals. Pharmacogenomics, as the main part of personalized medicine, aims to optimize and create a more targeted treatment approach based on genetic variations in drug response. It is predicted that future treatments will be algorithm-based instead of evidence-based that will consider a patient’s genetic, transcriptomic, proteomic, epigenetic, and lifestyle factors resulting in individualized medication. A generative pretrained transformer (GPT) is an artificial intelligence (AI) tool that generates language resembling human-like writing enabling users to engage in a manner that is practically identical to speaking with a human being. GPT’s predictive algorithms can respond to questions that have never been addressed. Chat Generative Pretrained Transformer (ChatGPT) is an AI chatbot’s advanced with conversational capabilities. In the present study, questions were asked from ChatGPT about the future of personalized medicine and pharmacogenomics. ChatGPT predicted both to be a promising approach with a bright future that holds great promises in improving patient outcomes and transforming the field of medicine. But it still has several limitations that need to be solved.
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来源期刊
Pharmacogenomics Journal
Pharmacogenomics Journal 医学-药学
CiteScore
7.20
自引率
0.00%
发文量
35
审稿时长
6-12 weeks
期刊介绍: The Pharmacogenomics Journal is a print and electronic journal, which is dedicated to the rapid publication of original research on pharmacogenomics and its clinical applications. Key areas of coverage include: Personalized medicine Effects of genetic variability on drug toxicity and efficacy Identification and functional characterization of polymorphisms relevant to drug action Pharmacodynamic and pharmacokinetic variations and drug efficacy Integration of new developments in the genome project and proteomics into clinical medicine, pharmacology, and therapeutics Clinical applications of genomic science Identification of novel genomic targets for drug development Potential benefits of pharmacogenomics.
期刊最新文献
Genetic association analysis and frequency of NUDT15*3 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease in a large Dutch cohort. Plasma concentrations of venetoclax and Pharmacogenetics correlated with drug efficacy in treatment naive leukemia patients: a retrospective study. Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study. Implementation of pharmacogenetic testing in pediatric oncology: barriers and facilitators assessment at eight Canadian academic health centres. Correction to: A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMETTM Plus platform.
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