她没有引起火灾:乳腺管上皮细胞抑制脂肪细胞的产热。

David Merrick
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摘要

雄性和雌性小鼠对冷诱导的皮下脂肪组织的产热beiging表现出高度不同的反应。最近在《自然》杂志上,Patel等人。显示乳腺管上皮细胞对冷诱导的交感神经活动作出反应,触发脂质运载蛋白2(LCN2)的分泌以抑制邻近乳腺脂肪细胞的产热分化。
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She didn't start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis.

Male and female mice display highly divergent responses to cold-induced thermogenic beiging of subcutaneous adipose tissues. Recently in Nature, Patel et al. showed that mammary duct epithelial cells respond to cold-induced sympathetic activity, triggering the secretion of lipocalin 2 (LCN2) to inhibit thermogenic differentiation of adjacent mammary adipocytes.

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