Carina A Ruano, Maria Francisca Moraes-Fontes, Alexandra Borba, Mónica Grafino, José Veiga, Otília Fernandes, Tiago Bilhim, Klaus L Irion
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T2-weighted images (T2-WI) were acquired by axial free-breathing respiratory-gated fat-suppressed \"periodically rotated overlapping parallel lines with enhanced reconstruction\" and T1-weighted images (T1-WI) by coronal end-expiratory breath-hold fat-suppressed \"volumetric interpolated breath-hold examination\" sequences, before and at time points T1, T3, T5, and T10 minutes after gadolinium administration. After MRI segmentation, signal intensity values were extracted by dedicated software. Percentage of the ILD volume and a ratio between signal intensity of ILD (SIILD) and normal lung (SInormal lung) were calculated for T2-WI; percentage of signal intensity (%SI) at each time point, time to peak enhancement, and percent relative enhancement of ILD in comparison with normal lung (%SIILD/normal lung) were calculated for T1-WI. MRI parameters at baseline were correlated with diagnosis of disease progression and variation in percent predicted forced vital capacity (%FVC) and diffusing capacity of the lung for carbon monoxide after 12 months.</p><p><strong>Results: </strong>Comprehensive MRI evaluation (T2-WI and T1-WI) was performed in 21 of the 25 patients enrolled (68% females; mean age: 62.6 y). Three of the 24 patients who completed follow-up fulfilled criteria for disease progression. Baseline T2-WI SIILD/SInormal lung was higher for the progression group (P = 0.052). T2-WI SIILD/SInormal lung and T1-WI %SIILD/normal lung at T1 were positively correlated with the 12-month variation in %FVC (r = 0.495, P = 0.014 and r = 0.489, P= 0.034, respectively).</p><p><strong>Conclusions: </strong>Baseline MRI parameters correlate with %FVC decline after 12 months.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lung Magnetic Resonance Imaging for Prediction of Progression in Patients With Nonidiopathic Pulmonary Fibrosis Interstitial Lung Disease: A Pilot Study.\",\"authors\":\"Carina A Ruano, Maria Francisca Moraes-Fontes, Alexandra Borba, Mónica Grafino, José Veiga, Otília Fernandes, Tiago Bilhim, Klaus L Irion\",\"doi\":\"10.1097/RTI.0000000000000744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Correlate magnetic resonance imaging (MRI) parameters at baseline with disease progression in nonidiopathic pulmonary fibrosis interstitial lung disease (ILD).</p><p><strong>Materials and methods: </strong>Prospective observational cohort study, in which patients with non-idiopathic pulmonary fibrosis ILD underwent MRI at baseline (1.5 T). T2-weighted images (T2-WI) were acquired by axial free-breathing respiratory-gated fat-suppressed \\\"periodically rotated overlapping parallel lines with enhanced reconstruction\\\" and T1-weighted images (T1-WI) by coronal end-expiratory breath-hold fat-suppressed \\\"volumetric interpolated breath-hold examination\\\" sequences, before and at time points T1, T3, T5, and T10 minutes after gadolinium administration. After MRI segmentation, signal intensity values were extracted by dedicated software. Percentage of the ILD volume and a ratio between signal intensity of ILD (SIILD) and normal lung (SInormal lung) were calculated for T2-WI; percentage of signal intensity (%SI) at each time point, time to peak enhancement, and percent relative enhancement of ILD in comparison with normal lung (%SIILD/normal lung) were calculated for T1-WI. MRI parameters at baseline were correlated with diagnosis of disease progression and variation in percent predicted forced vital capacity (%FVC) and diffusing capacity of the lung for carbon monoxide after 12 months.</p><p><strong>Results: </strong>Comprehensive MRI evaluation (T2-WI and T1-WI) was performed in 21 of the 25 patients enrolled (68% females; mean age: 62.6 y). Three of the 24 patients who completed follow-up fulfilled criteria for disease progression. Baseline T2-WI SIILD/SInormal lung was higher for the progression group (P = 0.052). 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引用次数: 0
摘要
目的：将非特发性肺纤维化间质性肺病（ILD）的基线磁共振成像（MRI）参数与疾病进展相关联。材料和方法：前瞻性观察性队列研究，其中非特发肺纤维化ILD患者在基线接受MRI检查（1.5 T） 。T2加权图像（T2-WI）通过轴向自由呼吸呼吸呼吸门控脂肪抑制“增强重建的周期性旋转重叠平行线”获得，T1加权图像（T1-WI）由冠状呼气末屏气脂肪抑制“容积内插屏气检查”序列获得，时间点T1、T3、T5，以及钆给药后T10分钟。MRI分割后，通过专用软件提取信号强度值。计算T2-WI的ILD体积百分比以及ILD的信号强度（SIILD）和正常肺（SInormal lung）之间的比率；计算T1-WI在每个时间点的信号强度百分比（%SI）、峰值增强时间以及ILD与正常肺相比的相对增强百分比（%SILD/正常肺）。基线时的MRI参数与疾病进展的诊断以及12个月后预测的用力肺活量百分比（%FVC）和肺部一氧化碳扩散能力的变化相关。结果：入选的25名患者中有21名（68%为女性；平均年龄：62.6岁）进行了综合MRI评估（T2-WI和T1-WI） y） 。24名完成随访的患者中，有3名符合疾病进展标准。进展组的基线T2-WI SIILD/正常肺更高（P=0.052）。T1时的T2-WI SI ILD/S正常肺和T1-WI%SI ILd/正常肺与12个月的%FVC变化呈正相关（分别为r=0.495，P=0.014和r=0.489，P=0.034）。结论：12个月后基线MRI参数与%FVC下降相关。
Lung Magnetic Resonance Imaging for Prediction of Progression in Patients With Nonidiopathic Pulmonary Fibrosis Interstitial Lung Disease: A Pilot Study.
Purpose: Correlate magnetic resonance imaging (MRI) parameters at baseline with disease progression in nonidiopathic pulmonary fibrosis interstitial lung disease (ILD).
Materials and methods: Prospective observational cohort study, in which patients with non-idiopathic pulmonary fibrosis ILD underwent MRI at baseline (1.5 T). T2-weighted images (T2-WI) were acquired by axial free-breathing respiratory-gated fat-suppressed "periodically rotated overlapping parallel lines with enhanced reconstruction" and T1-weighted images (T1-WI) by coronal end-expiratory breath-hold fat-suppressed "volumetric interpolated breath-hold examination" sequences, before and at time points T1, T3, T5, and T10 minutes after gadolinium administration. After MRI segmentation, signal intensity values were extracted by dedicated software. Percentage of the ILD volume and a ratio between signal intensity of ILD (SIILD) and normal lung (SInormal lung) were calculated for T2-WI; percentage of signal intensity (%SI) at each time point, time to peak enhancement, and percent relative enhancement of ILD in comparison with normal lung (%SIILD/normal lung) were calculated for T1-WI. MRI parameters at baseline were correlated with diagnosis of disease progression and variation in percent predicted forced vital capacity (%FVC) and diffusing capacity of the lung for carbon monoxide after 12 months.
Results: Comprehensive MRI evaluation (T2-WI and T1-WI) was performed in 21 of the 25 patients enrolled (68% females; mean age: 62.6 y). Three of the 24 patients who completed follow-up fulfilled criteria for disease progression. Baseline T2-WI SIILD/SInormal lung was higher for the progression group (P = 0.052). T2-WI SIILD/SInormal lung and T1-WI %SIILD/normal lung at T1 were positively correlated with the 12-month variation in %FVC (r = 0.495, P = 0.014 and r = 0.489, P= 0.034, respectively).
Conclusions: Baseline MRI parameters correlate with %FVC decline after 12 months.
期刊介绍：
Journal of Thoracic Imaging (JTI) provides authoritative information on all aspects of the use of imaging techniques in the diagnosis of cardiac and pulmonary diseases. Original articles and analytical reviews published in this timely journal provide the very latest thinking of leading experts concerning the use of chest radiography, computed tomography, magnetic resonance imaging, positron emission tomography, ultrasound, and all other promising imaging techniques in cardiopulmonary radiology.
Official Journal of the Society of Thoracic Radiology:
Japanese Society of Thoracic Radiology
Korean Society of Thoracic Radiology
European Society of Thoracic Imaging.
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