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The Conundrum of Computed Tomography Findings in Chronic Pulmonary Aspergillosis: Insights From 103 Cases.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-27 DOI: 10.1097/RTI.0000000000000828
Mandeep Garg, Harsimran Bhatia, Inderpaul Sehgal, Shritik Devkota, Nidhi Prabhakar, Uma Debi, Rajender Kumar, Shivaprakash M Rudramurthy, Valliapan Muthu, Ritesh Agarwal

Purpose: To describe the spectrum of computed tomography (CT) findings in various chronic pulmonary aspergillosis (CPA) subtypes.

Material and methods: This retrospective study analyzed the CT scans of consecutively diagnosed CPA cases. Two radiologists independently evaluated the CT findings (both qualitatively and quantitatively) to characterize the lung cavities, intracavitary contents, pericavitary opacities and fibrosis, mediastinal shift, pleural thickening, and underlying structural lung disease. Patients were then classified into CPA subtypes, and between-group differences were assessed using the sample t test, Wilcoxon test, χ2 test, and Fisher exact test.

Results: Among 103 patients with CPA (mean age: 47.26 ± 1.98 y; 69 men), 77.7%, 15.5%, and 6.8% were categorized as chronic cavitary pulmonary aspergillosis, chronic fibrosing pulmonary aspergillosis (CFPA), and single/simple aspergilloma, respectively. The mean symptom duration was 2.7 ± 3.96 years, with cough being the most common symptom (86.4%). Underlying post-tubercular lung abnormalities were observed in 97.1% of the patients. Cavities were observed in all patients (100%), most commonly in the left upper lobe (68.0%). The difference in cavity number among CPA subtypes was statistically significant (P = 0.003), with 87.5% CFPA and 41.5% chronic cavitary pulmonary aspergillosis cases showing multiple cavities. The overall median cavity wall thickness was 6 mm (interquartile range: 2.8), with the highest value in the CFPA. Pericavitary fibrosis was observed in 70.9% of overall cases and in 100% of CFPA cases (P < 0.001). Intracavitary contents were identified in 89.3% of patients. The median pleural thickness was 8 mm (interquartile range: 4), which was significantly different among CPA subtypes (P = 0.001). There was excellent interobserver agreement (k = 0.94) between the two readers. Posterior intercostal lymph nodes were identified in 66%, a novel CPA observation.

Conclusion: Comprehensive qualitative and quantitative assessment of CT findings improves the characterization of the CPA subtypes. The number and size of lung cavities, mediastinal shift, and pleural thickness, among other quantitative parameters, vary significantly across CPA subtypes, facilitating more accurate differentiation between them.

{"title":"The Conundrum of Computed Tomography Findings in Chronic Pulmonary Aspergillosis: Insights From 103 Cases.","authors":"Mandeep Garg, Harsimran Bhatia, Inderpaul Sehgal, Shritik Devkota, Nidhi Prabhakar, Uma Debi, Rajender Kumar, Shivaprakash M Rudramurthy, Valliapan Muthu, Ritesh Agarwal","doi":"10.1097/RTI.0000000000000828","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000828","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the spectrum of computed tomography (CT) findings in various chronic pulmonary aspergillosis (CPA) subtypes.</p><p><strong>Material and methods: </strong>This retrospective study analyzed the CT scans of consecutively diagnosed CPA cases. Two radiologists independently evaluated the CT findings (both qualitatively and quantitatively) to characterize the lung cavities, intracavitary contents, pericavitary opacities and fibrosis, mediastinal shift, pleural thickening, and underlying structural lung disease. Patients were then classified into CPA subtypes, and between-group differences were assessed using the sample t test, Wilcoxon test, χ2 test, and Fisher exact test.</p><p><strong>Results: </strong>Among 103 patients with CPA (mean age: 47.26 ± 1.98 y; 69 men), 77.7%, 15.5%, and 6.8% were categorized as chronic cavitary pulmonary aspergillosis, chronic fibrosing pulmonary aspergillosis (CFPA), and single/simple aspergilloma, respectively. The mean symptom duration was 2.7 ± 3.96 years, with cough being the most common symptom (86.4%). Underlying post-tubercular lung abnormalities were observed in 97.1% of the patients. Cavities were observed in all patients (100%), most commonly in the left upper lobe (68.0%). The difference in cavity number among CPA subtypes was statistically significant (P = 0.003), with 87.5% CFPA and 41.5% chronic cavitary pulmonary aspergillosis cases showing multiple cavities. The overall median cavity wall thickness was 6 mm (interquartile range: 2.8), with the highest value in the CFPA. Pericavitary fibrosis was observed in 70.9% of overall cases and in 100% of CFPA cases (P < 0.001). Intracavitary contents were identified in 89.3% of patients. The median pleural thickness was 8 mm (interquartile range: 4), which was significantly different among CPA subtypes (P = 0.001). There was excellent interobserver agreement (k = 0.94) between the two readers. Posterior intercostal lymph nodes were identified in 66%, a novel CPA observation.</p><p><strong>Conclusion: </strong>Comprehensive qualitative and quantitative assessment of CT findings improves the characterization of the CPA subtypes. The number and size of lung cavities, mediastinal shift, and pleural thickness, among other quantitative parameters, vary significantly across CPA subtypes, facilitating more accurate differentiation between them.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Pulmonary Injury: An Imaging and Clinical Review.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-17 DOI: 10.1097/RTI.0000000000000825
Taylor Sellers, Kirsten Alman, Maxwell Machurick, Hilary Faust, Jeffrey Kanne

Acute pulmonary injury can occur in response to any number of inciting factors. The body's response to these insults is much less diverse and usually categorizable as one of several patterns of disease defined by histopathology, with corresponding patterns on chest CT. Common patterns of acute injury include diffuse alveolar damage, organizing pneumonia, acute eosinophilic pneumonia, and hypersensitivity pneumonitis. The ultimate clinical diagnosis is multidisciplinary, requiring a detailed history and relevant laboratory investigations from referring clinicians, identification of injury patterns on imaging by radiologists, and sometimes tissue evaluation by pathologists. In this review, several clinical diagnoses will be explored, grouped by imaging pattern, with a representative clinical presentation, a review of the current literature, and a discussion of typical imaging findings. Additional information on terminology and disambiguation will be provided to assist with comprehension and standardization of descriptions. The focus will be on the acute phase of illness from presentation to diagnosis; treatment methods and chronic sequela of acute disease are beyond the scope of this review.

{"title":"Acute Pulmonary Injury: An Imaging and Clinical Review.","authors":"Taylor Sellers, Kirsten Alman, Maxwell Machurick, Hilary Faust, Jeffrey Kanne","doi":"10.1097/RTI.0000000000000825","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000825","url":null,"abstract":"<p><p>Acute pulmonary injury can occur in response to any number of inciting factors. The body's response to these insults is much less diverse and usually categorizable as one of several patterns of disease defined by histopathology, with corresponding patterns on chest CT. Common patterns of acute injury include diffuse alveolar damage, organizing pneumonia, acute eosinophilic pneumonia, and hypersensitivity pneumonitis. The ultimate clinical diagnosis is multidisciplinary, requiring a detailed history and relevant laboratory investigations from referring clinicians, identification of injury patterns on imaging by radiologists, and sometimes tissue evaluation by pathologists. In this review, several clinical diagnoses will be explored, grouped by imaging pattern, with a representative clinical presentation, a review of the current literature, and a discussion of typical imaging findings. Additional information on terminology and disambiguation will be provided to assist with comprehension and standardization of descriptions. The focus will be on the acute phase of illness from presentation to diagnosis; treatment methods and chronic sequela of acute disease are beyond the scope of this review.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative CT-based Radiomics Model for Predicting Micropapillary/Solid Patterns in Stage I Peripheral Lung Invasive Adenocarcinoma: A Propensity Score Matching Study.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-12 DOI: 10.1097/RTI.0000000000000826
Yachao Ruan, Meirong Li, Zhan Feng, Lvbin Xie, Fangyu Sun, Fenhua Zhao, Feng Chen

Purpose: To develop and validate an accurate computed tomography-based radiomics model for predicting high-grade (micropapillary/solid) patterns in T1-stage lung invasive adenocarcinoma (IAC) after propensity score matching (PSM).

Materials and methods: We enrolled 546 participants from 2 cohorts with histologically diagnosed lung IAC after complete surgical resection between January 2020 and August 2021. The patients were divided into high-grade and non-high-grade groups and matched using PSM. Matched patient HRCT images were used to delineate regions of interest from tumors and extract radiomics features, and the random forest method was used to construct a radiomics model. The area under the receiver operating characteristic curve (area under the curve) was used to evaluate the model's performance, and external validation was performed to assess the model's generalizability.

Results: Before PSM, there was no statistically significant difference in age between the two groups, though nodule type and sex exhibited significant differences (P < 0.05) in both cohorts. After PSM, we matched 176 and 97 pairs of patients in the 2 cohorts. In both cohorts, sex and nodule type were equal between the two groups, with a higher percentage of males and solid nodules in both groups. Our model exhibited moderate predictive performance after PSM, with area under the curve values of 0.75 (95% CI: 0.70-0.80) and 0.71 (95% CI: 0.63-0.80) for the development and external validation cohorts, respectively.

Conclusion: Although the nodule type compromised the validity of the model's performance, our results suggest that our acute computed tomography-based radiomics model could preoperatively predict micropapillary/solid patterns in patients with stage I lung IAC after PSM.

{"title":"Preoperative CT-based Radiomics Model for Predicting Micropapillary/Solid Patterns in Stage I Peripheral Lung Invasive Adenocarcinoma: A Propensity Score Matching Study.","authors":"Yachao Ruan, Meirong Li, Zhan Feng, Lvbin Xie, Fangyu Sun, Fenhua Zhao, Feng Chen","doi":"10.1097/RTI.0000000000000826","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000826","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate an accurate computed tomography-based radiomics model for predicting high-grade (micropapillary/solid) patterns in T1-stage lung invasive adenocarcinoma (IAC) after propensity score matching (PSM).</p><p><strong>Materials and methods: </strong>We enrolled 546 participants from 2 cohorts with histologically diagnosed lung IAC after complete surgical resection between January 2020 and August 2021. The patients were divided into high-grade and non-high-grade groups and matched using PSM. Matched patient HRCT images were used to delineate regions of interest from tumors and extract radiomics features, and the random forest method was used to construct a radiomics model. The area under the receiver operating characteristic curve (area under the curve) was used to evaluate the model's performance, and external validation was performed to assess the model's generalizability.</p><p><strong>Results: </strong>Before PSM, there was no statistically significant difference in age between the two groups, though nodule type and sex exhibited significant differences (P < 0.05) in both cohorts. After PSM, we matched 176 and 97 pairs of patients in the 2 cohorts. In both cohorts, sex and nodule type were equal between the two groups, with a higher percentage of males and solid nodules in both groups. Our model exhibited moderate predictive performance after PSM, with area under the curve values of 0.75 (95% CI: 0.70-0.80) and 0.71 (95% CI: 0.63-0.80) for the development and external validation cohorts, respectively.</p><p><strong>Conclusion: </strong>Although the nodule type compromised the validity of the model's performance, our results suggest that our acute computed tomography-based radiomics model could preoperatively predict micropapillary/solid patterns in patients with stage I lung IAC after PSM.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence Iterative Reconstruction for Dose Reduction in Pediatric Chest CT: A Clinical Assessment via Below 3 Years Patients With Congenital Heart Disease.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-27 DOI: 10.1097/RTI.0000000000000827
Feifei Zhang, Liying Peng, Guozhi Zhang, Ruigang Xie, Minghua Sun, Tao Su, Yinghui Ge

Purpose: To assess the performance of a newly introduced deep learning-based reconstruction algorithm, namely the artificial intelligence iterative reconstruction (AIIR), in reducing the dose of pediatric chest CT by using the image data of below 3-year-old patients with congenital heart disease (CHD).

Materials and methods: The lung image available from routine-dose cardiac CT angiography (CTA) on below 3 years patients with CHD was employed as a reference for evaluating the paired low-dose chest CT. A total of 191 subjects were prospectively enrolled, where the dose for chest CT was reduced to ~0.1 mSv while the cardiac CTA protocol was kept unchanged. The low-dose chest CT images, obtained with the AIIR and the hybrid iterative reconstruction (HIR), were compared in image quality, ie, overall image quality and lung structure depiction, and in diagnostic performance, ie, severity assessment of pneumonia and airway stenosis.

Results: Compared with the reference, lung image quality was not found significantly different on low-dose AIIR images (all P>0.05) but obviously inferior with the HIR (all P<0.05). Compared with the HIR, low-dose AIIR images also achieved a closer pneumonia severity index (AIIR 4.32±3.82 vs. Ref 4.37±3.84, P>0.05; HIR 5.12±4.06 vs. Ref 4.37±3.84, P<0.05) and airway stenosis grading (consistently graded: AIIR 88.5% vs. HIR 56.5% ) to the reference.

Conclusions: AIIR has the potential for large dose reduction in chest CT of patients below 3 years of age while preserving image quality and achieving diagnostic results nearly equivalent to routine dose scans.

{"title":"Artificial Intelligence Iterative Reconstruction for Dose Reduction in Pediatric Chest CT: A Clinical Assessment via Below 3 Years Patients With Congenital Heart Disease.","authors":"Feifei Zhang, Liying Peng, Guozhi Zhang, Ruigang Xie, Minghua Sun, Tao Su, Yinghui Ge","doi":"10.1097/RTI.0000000000000827","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000827","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the performance of a newly introduced deep learning-based reconstruction algorithm, namely the artificial intelligence iterative reconstruction (AIIR), in reducing the dose of pediatric chest CT by using the image data of below 3-year-old patients with congenital heart disease (CHD).</p><p><strong>Materials and methods: </strong>The lung image available from routine-dose cardiac CT angiography (CTA) on below 3 years patients with CHD was employed as a reference for evaluating the paired low-dose chest CT. A total of 191 subjects were prospectively enrolled, where the dose for chest CT was reduced to ~0.1 mSv while the cardiac CTA protocol was kept unchanged. The low-dose chest CT images, obtained with the AIIR and the hybrid iterative reconstruction (HIR), were compared in image quality, ie, overall image quality and lung structure depiction, and in diagnostic performance, ie, severity assessment of pneumonia and airway stenosis.</p><p><strong>Results: </strong>Compared with the reference, lung image quality was not found significantly different on low-dose AIIR images (all P>0.05) but obviously inferior with the HIR (all P<0.05). Compared with the HIR, low-dose AIIR images also achieved a closer pneumonia severity index (AIIR 4.32±3.82 vs. Ref 4.37±3.84, P>0.05; HIR 5.12±4.06 vs. Ref 4.37±3.84, P<0.05) and airway stenosis grading (consistently graded: AIIR 88.5% vs. HIR 56.5% ) to the reference.</p><p><strong>Conclusions: </strong>AIIR has the potential for large dose reduction in chest CT of patients below 3 years of age while preserving image quality and achieving diagnostic results nearly equivalent to routine dose scans.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantification of Left Ventricular Trabecular Complexity in Patients With Hypertrophic Cardiomyopathy by Cardiovascular Magnetic Resonance Imaging Fractal Analysis: A Feasibility and Reproducibility Study.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-20 DOI: 10.1097/RTI.0000000000000823
Xin Zhang, Jinyang Wen, Xuepei Tang, Xinwei Tao, Weiyin Vivian Liu, Tian Zheng, Shuhao Li, Shuli Zhou, Jingjing Zhou, Xuan Xiao, Qimin Fang, Lianggeng Gong

Purpose: To investigate the left ventricular (LV) trabecular complexity and evaluate its relationship with LV cardiac function and especially myocardial strain in patients with hypertrophic cardiomyopathy (HCM).

Materials and methods: A total of 100 patients were retrospectively recruited in the study, including 50 obstructive hypertrophic cardiomyopathy (HOCM) and 50 nonobstructive HCM (NOHCM). Fifty age-matched and sex-matched healthy participants were also enrolled. The global and regional LV fractal dimensions (FDs), the global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS) for LV were measured. FDs and myocardial strain parameters among 3 groups with post hoc paired comparisons. Correlations analysis and receiver operating characteristic analysis were performed.

Results: Mean global FD, max basal FD, and max apical FD were higher in patients with HCM compared with the healthy individuals (1.310 ± 0.046 vs 1.229 ± 0.027, 1.388 ± 0.089 vs 1.313 ± 0.039, 1.393 ± 0.108 vs 1.270 ± 0.041, all P < 0.001). Patients with HOCM showed significantly higher max apical FD than patients with NOHCM (1.432 ± 0.100 vs 1.355 ± 0.102, P < 0.001). The increased global FD was associated with reduced myocardial deformation across all 3 measures of global strain (GCS: r = 0.529, P < 0.001; GLS: r = 0.54, P < 0.001; GRS: r = -0.253, P = 0.002). Max apical FD yielded an area under the curve of 0.73 (95% CI: 0.63-0.83) for discriminating HOCM from NOHCM.

Conclusions: LV trabecular complexity is compensatively increased in patients with HCM and the max apical FD was more pronounced in patients with HOCM. The increased LV global trabecular complexity might be correlated with LV systolic dysfunction.

{"title":"Quantification of Left Ventricular Trabecular Complexity in Patients With Hypertrophic Cardiomyopathy by Cardiovascular Magnetic Resonance Imaging Fractal Analysis: A Feasibility and Reproducibility Study.","authors":"Xin Zhang, Jinyang Wen, Xuepei Tang, Xinwei Tao, Weiyin Vivian Liu, Tian Zheng, Shuhao Li, Shuli Zhou, Jingjing Zhou, Xuan Xiao, Qimin Fang, Lianggeng Gong","doi":"10.1097/RTI.0000000000000823","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000823","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the left ventricular (LV) trabecular complexity and evaluate its relationship with LV cardiac function and especially myocardial strain in patients with hypertrophic cardiomyopathy (HCM).</p><p><strong>Materials and methods: </strong>A total of 100 patients were retrospectively recruited in the study, including 50 obstructive hypertrophic cardiomyopathy (HOCM) and 50 nonobstructive HCM (NOHCM). Fifty age-matched and sex-matched healthy participants were also enrolled. The global and regional LV fractal dimensions (FDs), the global radial, circumferential, and longitudinal strain (GRS, GCS, and GLS) for LV were measured. FDs and myocardial strain parameters among 3 groups with post hoc paired comparisons. Correlations analysis and receiver operating characteristic analysis were performed.</p><p><strong>Results: </strong>Mean global FD, max basal FD, and max apical FD were higher in patients with HCM compared with the healthy individuals (1.310 ± 0.046 vs 1.229 ± 0.027, 1.388 ± 0.089 vs 1.313 ± 0.039, 1.393 ± 0.108 vs 1.270 ± 0.041, all P < 0.001). Patients with HOCM showed significantly higher max apical FD than patients with NOHCM (1.432 ± 0.100 vs 1.355 ± 0.102, P < 0.001). The increased global FD was associated with reduced myocardial deformation across all 3 measures of global strain (GCS: r = 0.529, P < 0.001; GLS: r = 0.54, P < 0.001; GRS: r = -0.253, P = 0.002). Max apical FD yielded an area under the curve of 0.73 (95% CI: 0.63-0.83) for discriminating HOCM from NOHCM.</p><p><strong>Conclusions: </strong>LV trabecular complexity is compensatively increased in patients with HCM and the max apical FD was more pronounced in patients with HOCM. The increased LV global trabecular complexity might be correlated with LV systolic dysfunction.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of Single-dose Transcatheter Aortic Valve Replacement Planning CT Angiography for the Detection of Coronary Artery Disease.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-07 DOI: 10.1097/RTI.0000000000000824
Florian T Gassert, Torkel B Brismar, Taha Durukan, Raquel Themudo, Anders Svensson-Marcial

Purpose: To assess the accuracy of transaortic valve replacement (TAVR) planning CT examinations with a broad detector and a single dose of contrast media to diagnose CAD in a large patient cohort.

Materials and methods: In this retrospective study, consecutive patients who underwent a dedicated TAVR planning CT examination with a single contrast media dose and a 320-detector row between November 2017 and March 2021 were screened for inclusion. Inclusion criteria were a complete and correctly performed CT exam as well as an invasive coronary angiography (ICA). The scan consisted of 3 series: (1) ECG-triggered calcium score series over the heart. (2) ECG triggered i.v. CM scanning over the heart covering the entire cardiac cycle (0% to 100%). (3) non-ECG triggered scanning over the thoracic-abdominal area including subclavian and femoral arteries. For 2 and 3, a single i.v. CM bolus was used (300 mg iodine per kg total body weight of iodixanol, minimum 47 mL, maximum 75 mL at 100 kVp; 90 mL at 120 kVp). CT-derived CAD was defined as either free of obstructive CAD (<50%) or showing obstructive disease (>50%), further subclassified in moderate stenosis (50%-70%), or severe stenosis (>70%) for each vessel. ICA data were used as standard of reference.

Results: We studied 599 patients (78.6±7.5 y, 358 men). In ICA, 428 of 2396 coronary vessels (17.8%) demonstrated stenosis of 50% or more. In a per-patient analysis, CTA had a sensitivity of 97.6% and specificity of 84.3% for the detection of patients with at least one vessel with stenosis of 50% or more as well as a NPV and PPV of 97.8% and 82.2%, respectively. In a per-vessel analysis, CTA had 80.8% sensitivity and 88.1% specificity for the detection of stenosis of 50% or more, as well as an NPV and PPV of 95.5% and 59.6%, respectively.

Conclusions: Single-dose TAVR planning CT imaging with a wide detector has high sensitivity and NPV to exclude at least moderate CAD in TAVR candidates.

{"title":"Accuracy of Single-dose Transcatheter Aortic Valve Replacement Planning CT Angiography for the Detection of Coronary Artery Disease.","authors":"Florian T Gassert, Torkel B Brismar, Taha Durukan, Raquel Themudo, Anders Svensson-Marcial","doi":"10.1097/RTI.0000000000000824","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000824","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the accuracy of transaortic valve replacement (TAVR) planning CT examinations with a broad detector and a single dose of contrast media to diagnose CAD in a large patient cohort.</p><p><strong>Materials and methods: </strong>In this retrospective study, consecutive patients who underwent a dedicated TAVR planning CT examination with a single contrast media dose and a 320-detector row between November 2017 and March 2021 were screened for inclusion. Inclusion criteria were a complete and correctly performed CT exam as well as an invasive coronary angiography (ICA). The scan consisted of 3 series: (1) ECG-triggered calcium score series over the heart. (2) ECG triggered i.v. CM scanning over the heart covering the entire cardiac cycle (0% to 100%). (3) non-ECG triggered scanning over the thoracic-abdominal area including subclavian and femoral arteries. For 2 and 3, a single i.v. CM bolus was used (300 mg iodine per kg total body weight of iodixanol, minimum 47 mL, maximum 75 mL at 100 kVp; 90 mL at 120 kVp). CT-derived CAD was defined as either free of obstructive CAD (<50%) or showing obstructive disease (>50%), further subclassified in moderate stenosis (50%-70%), or severe stenosis (>70%) for each vessel. ICA data were used as standard of reference.</p><p><strong>Results: </strong>We studied 599 patients (78.6±7.5 y, 358 men). In ICA, 428 of 2396 coronary vessels (17.8%) demonstrated stenosis of 50% or more. In a per-patient analysis, CTA had a sensitivity of 97.6% and specificity of 84.3% for the detection of patients with at least one vessel with stenosis of 50% or more as well as a NPV and PPV of 97.8% and 82.2%, respectively. In a per-vessel analysis, CTA had 80.8% sensitivity and 88.1% specificity for the detection of stenosis of 50% or more, as well as an NPV and PPV of 95.5% and 59.6%, respectively.</p><p><strong>Conclusions: </strong>Single-dose TAVR planning CT imaging with a wide detector has high sensitivity and NPV to exclude at least moderate CAD in TAVR candidates.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of Streak Artifacts in the Superior Vena Cava for Better Visualization of Mediastinal Structures Through Virtual Monoenergetic Reconstructions Using a Photon-counting Detector Computed Tomography.
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-31 DOI: 10.1097/RTI.0000000000000822
Greta Thater, Isabel Frerichs, Sylvia Büttner, Stefan O Schoenberg, Matthias Froelich, Isabelle Ayx

Purpose: Computed tomography (CT) is crucial in oncologic imaging for precise diagnosis and staging. Beam-hardening artifacts from contrast media in the superior vena cava can degrade image quality and obscure adjacent structures, complicating lymph node assessment. This study examines the use of virtual monoenergetic reconstruction with photon-counting detector CT (photon-counting CT) to mitigate these artifacts.

Materials and methods: The retrospective study included 50 patients who underwent thoracoabdominal scans. Virtual monoenergetic reconstructions at nine keV levels (60 to 140 keV) were analyzed for Hounsfield Unit (HU) stability, image noise, and artifact index in various regions of interest (ROIs): mediastinal adipose tissue (ROI 1 to 3) and vascular stations (ROI 4 to 6) were compared with reference tissue (ROI 7 to 8). The diagnostic image quality of the keV levels was assessed using a 5-point Likert Scale.

Results: Lower keV values (60 to 80) exhibited higher image noise and lower HU stability in mediastinal adipose tissue compared with higher energies, with optimal noise reduction observed at 130 keV (ROI 1 to 3). HU stability in vascular structures (ROI 4 to 6) significantly improved above 80 keV, with the best performance at 140 keV. Artifact levels decreased progressively from 60 to 140 keV. Visually, keV levels of 110 keV (96% Likert ≥4) and 120 keV (60% Likert 4) were rated most diagnostically valuable, consistent with technical findings.

Conclusion: Virtual monoenergetic reconstructions with photon-counting CT effectively reduce beam-hardening artifacts near the superior vena cava, enhancing the visualization of lymph nodes and adjacent structures. This technology advances oncologic imaging by improving diagnostic accuracy in areas previously affected by artifact-related image degradation.

{"title":"Reduction of Streak Artifacts in the Superior Vena Cava for Better Visualization of Mediastinal Structures Through Virtual Monoenergetic Reconstructions Using a Photon-counting Detector Computed Tomography.","authors":"Greta Thater, Isabel Frerichs, Sylvia Büttner, Stefan O Schoenberg, Matthias Froelich, Isabelle Ayx","doi":"10.1097/RTI.0000000000000822","DOIUrl":"10.1097/RTI.0000000000000822","url":null,"abstract":"<p><strong>Purpose: </strong>Computed tomography (CT) is crucial in oncologic imaging for precise diagnosis and staging. Beam-hardening artifacts from contrast media in the superior vena cava can degrade image quality and obscure adjacent structures, complicating lymph node assessment. This study examines the use of virtual monoenergetic reconstruction with photon-counting detector CT (photon-counting CT) to mitigate these artifacts.</p><p><strong>Materials and methods: </strong>The retrospective study included 50 patients who underwent thoracoabdominal scans. Virtual monoenergetic reconstructions at nine keV levels (60 to 140 keV) were analyzed for Hounsfield Unit (HU) stability, image noise, and artifact index in various regions of interest (ROIs): mediastinal adipose tissue (ROI 1 to 3) and vascular stations (ROI 4 to 6) were compared with reference tissue (ROI 7 to 8). The diagnostic image quality of the keV levels was assessed using a 5-point Likert Scale.</p><p><strong>Results: </strong>Lower keV values (60 to 80) exhibited higher image noise and lower HU stability in mediastinal adipose tissue compared with higher energies, with optimal noise reduction observed at 130 keV (ROI 1 to 3). HU stability in vascular structures (ROI 4 to 6) significantly improved above 80 keV, with the best performance at 140 keV. Artifact levels decreased progressively from 60 to 140 keV. Visually, keV levels of 110 keV (96% Likert ≥4) and 120 keV (60% Likert 4) were rated most diagnostically valuable, consistent with technical findings.</p><p><strong>Conclusion: </strong>Virtual monoenergetic reconstructions with photon-counting CT effectively reduce beam-hardening artifacts near the superior vena cava, enhancing the visualization of lymph nodes and adjacent structures. This technology advances oncologic imaging by improving diagnostic accuracy in areas previously affected by artifact-related image degradation.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Aspiration Syndromes: An Imaging-based Review. 肺吸入综合征:基于影像学的回顾。
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-14 DOI: 10.1097/RTI.0000000000000821
Stuti Chandola, Ashu Seith Bhalla, Manisha Jana, Priyanka Naranje, Surabhi Vyas

The term "aspiration" describes lung injury that results from unintentional passage of contents other than air into the lungs and bronchial tree, commonly from the gastrointestinal and upper respiratory tracts. Only a small proportion of aspiration-related events are symptomatic, especially in predisposed individuals such as patients with diminished consciousness, impaired swallowing, oesophageal motility disorders, and reflux disease. Aspiration-related syndromes can be classified based on the onset of presentation, composition of the aspirated substance, and anatomic site of injury. When considering the injury site, the aspirated material can either obstruct the airways, thereby presenting with obstructive features (eg, atelectasis on radiographs); it can alternatively affect the lung parenchyma. Lung injury due to aspiration of noxious agents such as acid or lipids is termed chemical aspiration pneumonitis. The aspirated contents can alternatively lead to lung parenchymal infection when the contents are infected, which is termed aspiration pneumonia. We have reviewed the imaging manifestations of various entities related to aspiration and have classified the abnormalities based on the site of injury and the nature of the culprit agent. Differences between "aspiration pneumonitis" and "aspiration pneumonia" are also explored. This is followed by an illustration of a few specific situations related to aspiration in pediatric and adult patients.

“误吸”一词描述的是由非空气的内容物意外进入肺部和支气管而引起的肺损伤,通常来自胃肠道和上呼吸道。只有一小部分与吸气相关的事件是有症状的,特别是在易感个体中,如意识减退、吞咽受损、食管运动障碍和反流疾病的患者。吸入相关综合征可根据发病、吸入物质的组成和损伤的解剖部位进行分类。在考虑损伤部位时,吸入的物质可能阻塞气道,从而表现为梗阻性特征(如x线片上的肺不张);它可交替影响肺实质。吸入有害物质如酸或脂质引起的肺损伤称为化学性吸入性肺炎。当吸入内容物被感染时,吸入内容物可引起肺实质感染,称为吸入性肺炎。我们回顾了与误吸相关的各种实体的影像学表现,并根据损伤部位和罪魁祸首的性质对异常进行了分类。探讨了“吸入性肺炎”与“吸入性肺炎”的区别。接下来是与儿科和成人患者误吸相关的几个具体情况的说明。
{"title":"Pulmonary Aspiration Syndromes: An Imaging-based Review.","authors":"Stuti Chandola, Ashu Seith Bhalla, Manisha Jana, Priyanka Naranje, Surabhi Vyas","doi":"10.1097/RTI.0000000000000821","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000821","url":null,"abstract":"<p><p>The term \"aspiration\" describes lung injury that results from unintentional passage of contents other than air into the lungs and bronchial tree, commonly from the gastrointestinal and upper respiratory tracts. Only a small proportion of aspiration-related events are symptomatic, especially in predisposed individuals such as patients with diminished consciousness, impaired swallowing, oesophageal motility disorders, and reflux disease. Aspiration-related syndromes can be classified based on the onset of presentation, composition of the aspirated substance, and anatomic site of injury. When considering the injury site, the aspirated material can either obstruct the airways, thereby presenting with obstructive features (eg, atelectasis on radiographs); it can alternatively affect the lung parenchyma. Lung injury due to aspiration of noxious agents such as acid or lipids is termed chemical aspiration pneumonitis. The aspirated contents can alternatively lead to lung parenchymal infection when the contents are infected, which is termed aspiration pneumonia. We have reviewed the imaging manifestations of various entities related to aspiration and have classified the abnormalities based on the site of injury and the nature of the culprit agent. Differences between \"aspiration pneumonitis\" and \"aspiration pneumonia\" are also explored. This is followed by an illustration of a few specific situations related to aspiration in pediatric and adult patients.</p>","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Changes of CT-radiomic and Systemic Inflammatory Features Predict Survival in Advanced Non-Small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors. CT放射学和全身炎症特征的纵向变化可预测接受免疫检查点抑制剂治疗的晚期非小细胞肺癌患者的生存期
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-01 DOI: 10.1097/RTI.0000000000000801
Maurizio Balbi, Giulia Mazzaschi, Ludovica Leo, Lucas Moron Dalla Tor, Gianluca Milanese, Cristina Marrocchio, Mario Silva, Rebecca Mura, Pasquale Favia, Giovanni Bocchialini, Francesca Trentini, Roberta Minari, Luca Ampollini, Federico Quaini, Giovanni Roti, Marcello Tiseo, Nicola Sverzellati

Purpose: This study aims to determine whether longitudinal changes in CT radiomic features (RFs) and systemic inflammatory indices outperform single-time-point assessment in predicting survival in advanced non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs).

Materials and methods: We retrospectively acquired pretreatment (T0) and first disease assessment (T1) RFs and systemic inflammatory indices from a single-center cohort of stage IV NSCLC patients and computed their delta (Δ) variation as [(T1-T0)/T0]. RFs from the primary tumor were selected for building baseline-radiomic (RAD) and Δ-RAD scores using the linear combination of standardized predictors detected by LASSO Cox regression models. Cox models were generated using clinical features alone or combined with baseline and Δ blood parameters and integrated with baseline-RAD and Δ-RAD. All models were 3-fold cross-validated. A prognostic index (PI) of each model was tested to stratify overall survival (OS) through Kaplan-Meier analysis.

Results: We included 90 ICI-treated NSCLC patients (median age 70 y [IQR=42 to 85], 63 males). Δ-RAD outperformed baseline-RAD for predicting OS [c-index: 0.632 (95%CI: 0.628 to 0.636) vs. 0.605 (95%CI: 0.601 to 0.608) in the test splits]. Integrating longitudinal changes of systemic inflammatory indices and Δ-RAD with clinical data led to the best model performance [Integrated-Δ model, c-index: 0.750 (95% CI: 0.749 to 0.751) in training and 0.718 (95% CI: 0.715 to 0.721) in testing splits]. PI enabled significant OS stratification within all the models ( P -value <0.01), reaching the greatest discriminative ability in Δ models (high-risk group HR up to 7.37, 95% CI: 3.9 to 13.94, P <0.01).

Conclusion: Δ-RAD improved OS prediction compared with single-time-point radiomic in advanced ICI-treated NSCLC. Integrating Δ-RAD with a longitudinal assessment of clinical and laboratory data further improved the prognostic performance.

目的:本研究旨在确定在预测接受免疫检查点抑制剂(ICIs)治疗的晚期非小细胞肺癌(NSCLC)患者的生存率方面,CT放射学特征(RFs)和全身炎症指数的纵向变化是否优于单时点评估:我们回顾性地从单中心队列的IV期NSCLC患者中获取了治疗前(T0)和首次疾病评估(T1)的射频和全身炎症指数,并计算了它们的delta (Δ)变化,即[(T1-T0)/T0]。利用 LASSO Cox 回归模型检测到的标准化预测因子的线性组合,从原发肿瘤中筛选出 RFs,用于建立基线-放射组学(RAD)和 Δ-RAD 评分。Cox模型单独使用临床特征或与基线和Δ血液参数相结合生成,并与基线-RAD和Δ-RAD相结合。所有模型均经过 3 倍交叉验证。通过 Kaplan-Meier 分析,测试了每个模型的预后指数(PI),以对总生存期(OS)进行分层:我们纳入了90名接受过ICI治疗的NSCLC患者(中位年龄70岁[IQR=42至85岁],63名男性)。Δ-RAD在预测OS方面优于基线-RAD[c-指数:0.632(95%C)]:c-index: 0.632 (95%CI: 0.628 to 0.636) vs. 0.605 (95%CI: 0.601 to 0.608) in the test splits]。将全身炎症指数和Δ-RAD的纵向变化与临床数据相结合,可获得最佳的模型性能[综合-Δ模型,c-指数:0.750 (95% CI: 0.628 to 0.636) vs. 测试分割:0.605 (95%CI: 0.601 to 0.608]:在训练分区中为 0.750(95% CI:0.749 至 0.751),在测试分区中为 0.718(95% CI:0.715 至 0.721)]。在所有模型中,PI都能对OS进行明显的分层(P值 结论:在晚期ICI治疗的NSCLC中,与单时点放射组学相比,Δ-RAD能改善OS预测。将Δ-RAD与临床和实验室数据的纵向评估相结合,可进一步提高预后效果。
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引用次数: 0
Radiomics Analysis for the Identification of Invasive Pulmonary Subsolid Nodules From Longitudinal Presurgical CT Scans. 从纵向手术前 CT 扫描中识别侵袭性肺实性下结节的放射组学分析
IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-01 DOI: 10.1097/RTI.0000000000000800
Apurva Singh, Leonid Roshkovan, Hannah Horng, Andrew Chen, Sharyn I Katz, Jeffrey C Thompson, Despina Kontos

Purpose: Effective identification of malignant part-solid lung nodules is crucial to eliminate risks due to therapeutic intervention or lack thereof. We aimed to develop delta radiomics and volumetric signatures, characterize changes in nodule properties over three presurgical time points, and assess the accuracy of nodule invasiveness identification when combined with immediate presurgical time point radiomics signature and clinical biomarkers.

Materials and methods: Cohort included 156 part-solid lung nodules with immediate presurgical CT scans and a subset of 122 nodules with scans at 3 presurgical time points. Region of interest segmentation was performed using ITK-SNAP, and feature extraction using CaPTk. Image parameter heterogeneity was mitigated at each time point using nested ComBat harmonization. For 122 nodules, delta radiomics features (ΔR AB = (R B -R A )/R A ) and delta volumes (ΔV AB = (V B -V A )/V A ) were computed between the time points. Principal Component Analysis was performed to construct immediate presurgical radiomics (Rs 1 ) and delta radiomics signatures (ΔRs 31 + ΔRs 21 + ΔRs 32 ). Identification of nodule pathology was performed using logistic regression on delta radiomics and immediate presurgical time point signatures, delta volumes (ΔV 31 + ΔV 21 + ΔV 32 ), and clinical variable (smoking status, BMI) models (train test split (2:1)).

Results: In delta radiomics analysis (n= 122 nodules), the best-performing model combined immediate pre-surgical time point and delta radiomics signatures, delta volumes, and clinical factors (classification accuracy [AUC]): (77.5% [0.73]) (train); (71.6% [0.69]) (test).

Conclusions: Delta radiomics and volumes can detect changes in nodule properties over time, which are predictive of nodule invasiveness. These tools could improve conventional radiologic assessment, allow for earlier intervention for aggressive nodules, and decrease unnecessary intervention-related morbidity.

目的:有效识别恶性部分实性肺结节对于消除因治疗干预或缺乏治疗干预导致的风险至关重要。我们旨在开发δ放射组学和容积特征,描述手术前三个时间点结节性质的变化,并评估结合手术前即时时间点放射组学特征和临床生物标志物识别结节侵袭性的准确性:队列包括156个部分实性肺部结节和122个在术前三个时间点扫描的结节子集。使用 ITK-SNAP 进行感兴趣区分割,并使用 CaPTk 进行特征提取。每个时间点的图像参数异质性通过嵌套 ComBat 协调来缓解。对于 122 个结节,计算了各时间点之间的 delta 放射性组学特征(ΔRAB= (RB-RA)/RA)和 delta 体积(ΔVAB= (VB-VA)/VA)。通过主成分分析,构建手术前即时放射组学特征(Rs1)和δ放射组学特征(ΔRs31+ ΔRs21+ ΔRs32)。结节病理学的鉴定是通过对δ放射组学和即时手术前时间点特征、δ体积(ΔV31+ ΔV21+ ΔV32)和临床变量(吸烟状态、体重指数)模型(train test split (2:1))的逻辑回归进行的:在Δ放射组学分析中(n= 122个结节),表现最好的模型结合了手术前即时时间点和Δ放射组学特征、Δ体积和临床因素(分类准确率[AUC]):(77.5% [0.73])(训练);(71.6% [0.69])(测试):结论:德尔塔放射组学和容积可检测结节随时间发生的性质变化,这些变化可预测结节的侵袭性。这些工具可以改善传统的放射学评估,对侵袭性结节进行早期干预,并降低不必要的干预相关发病率。
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引用次数: 0
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Journal of Thoracic Imaging
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