Chaofeng Wang, Jie Lei, Congyang Mao, Shuilin Wu, Yufeng Zheng, Chunyong Liang, Lei Yang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Yu Zhang, Cao Yang, Xiangmei Liu
{"title":"缺陷S-TiO2−x/CeO2异质结用于相互增强化学动力学/声催化抗菌治疗和声电/离子活化骨再生","authors":"Chaofeng Wang, Jie Lei, Congyang Mao, Shuilin Wu, Yufeng Zheng, Chunyong Liang, Lei Yang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Yu Zhang, Cao Yang, Xiangmei Liu","doi":"10.1002/adfm.202306493","DOIUrl":null,"url":null,"abstract":"<p>Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role in sonocatalysis and chemodynamics, and how to regulate electron transfer and achieve mutual-reinforcement between sonocatalysis and chemodynamic to achieve efficient antibacterial therapy is a difficult problem. Here, this study develops a defective S-doped TiO<sub>2</sub> and CeO<sub>2</sub> heterojunction(S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub>)sonosensitizer that can enhance chemodynamic therapy by regulating valence transitions of Ce<sup>III</sup>/Ce<sup>IV</sup> by sonoelectrons, and enhancing sonocatalytic therapy by creating heterojunctions to accelerate the transfer of interface electron, thereby achieving mutual reinforcement of sonocatalysis and chemodynamic. It could kill 99.3% of <i>S. aureus</i> under ultrasound (US) irradiation . Due to the presence of mixed valence states Ce<sup>III</sup>/Ce<sup>IV</sup> in CeO<sub>2</sub>, S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> could be as oxy-substrates. Ce<sup>4+</sup> can deplete glutathione and reacts with H<sub>2</sub>O<sub>2</sub> in bacteria to produce reactive oxygen species (ROS). These activities combines with ROS generated from sonocatalysis, resulting in bacterial death. Meanwhile, the electrical signal generated by S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> under US stimulation and the cerium ions could activate the Wnt/β-catenin signaling pathway to induce hBMSCs to differentiate into osteoblast. S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> successfully treats osteomyelitis under US irradiation by effectively clearing infection, suppressing inflammatory, and promoting bone regeneration, and it provides effective treatment for patients with deep infection.</p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":null,"pages":null},"PeriodicalIF":18.5000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Defective S-TiO2−x/CeO2 Heterojunction for Mutual Reinforcing Chemodynamic/Sonocatalytic Antibacterial Therapy and Sonoelectric/Ion-Activated Bone Regeneration\",\"authors\":\"Chaofeng Wang, Jie Lei, Congyang Mao, Shuilin Wu, Yufeng Zheng, Chunyong Liang, Lei Yang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Yu Zhang, Cao Yang, Xiangmei Liu\",\"doi\":\"10.1002/adfm.202306493\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role in sonocatalysis and chemodynamics, and how to regulate electron transfer and achieve mutual-reinforcement between sonocatalysis and chemodynamic to achieve efficient antibacterial therapy is a difficult problem. Here, this study develops a defective S-doped TiO<sub>2</sub> and CeO<sub>2</sub> heterojunction(S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub>)sonosensitizer that can enhance chemodynamic therapy by regulating valence transitions of Ce<sup>III</sup>/Ce<sup>IV</sup> by sonoelectrons, and enhancing sonocatalytic therapy by creating heterojunctions to accelerate the transfer of interface electron, thereby achieving mutual reinforcement of sonocatalysis and chemodynamic. It could kill 99.3% of <i>S. aureus</i> under ultrasound (US) irradiation . Due to the presence of mixed valence states Ce<sup>III</sup>/Ce<sup>IV</sup> in CeO<sub>2</sub>, S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> could be as oxy-substrates. Ce<sup>4+</sup> can deplete glutathione and reacts with H<sub>2</sub>O<sub>2</sub> in bacteria to produce reactive oxygen species (ROS). These activities combines with ROS generated from sonocatalysis, resulting in bacterial death. Meanwhile, the electrical signal generated by S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> under US stimulation and the cerium ions could activate the Wnt/β-catenin signaling pathway to induce hBMSCs to differentiate into osteoblast. S-TiO<sub>2−</sub><i><sub>x</sub></i>/CeO<sub>2</sub> successfully treats osteomyelitis under US irradiation by effectively clearing infection, suppressing inflammatory, and promoting bone regeneration, and it provides effective treatment for patients with deep infection.</p>\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":18.5000,\"publicationDate\":\"2023-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202306493\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adfm.202306493","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Defective S-TiO2−x/CeO2 Heterojunction for Mutual Reinforcing Chemodynamic/Sonocatalytic Antibacterial Therapy and Sonoelectric/Ion-Activated Bone Regeneration
Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role in sonocatalysis and chemodynamics, and how to regulate electron transfer and achieve mutual-reinforcement between sonocatalysis and chemodynamic to achieve efficient antibacterial therapy is a difficult problem. Here, this study develops a defective S-doped TiO2 and CeO2 heterojunction(S-TiO2−x/CeO2)sonosensitizer that can enhance chemodynamic therapy by regulating valence transitions of CeIII/CeIV by sonoelectrons, and enhancing sonocatalytic therapy by creating heterojunctions to accelerate the transfer of interface electron, thereby achieving mutual reinforcement of sonocatalysis and chemodynamic. It could kill 99.3% of S. aureus under ultrasound (US) irradiation . Due to the presence of mixed valence states CeIII/CeIV in CeO2, S-TiO2−x/CeO2 could be as oxy-substrates. Ce4+ can deplete glutathione and reacts with H2O2 in bacteria to produce reactive oxygen species (ROS). These activities combines with ROS generated from sonocatalysis, resulting in bacterial death. Meanwhile, the electrical signal generated by S-TiO2−x/CeO2 under US stimulation and the cerium ions could activate the Wnt/β-catenin signaling pathway to induce hBMSCs to differentiate into osteoblast. S-TiO2−x/CeO2 successfully treats osteomyelitis under US irradiation by effectively clearing infection, suppressing inflammatory, and promoting bone regeneration, and it provides effective treatment for patients with deep infection.
期刊介绍:
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