Hadi Soltani Nejad, Fariba Garkani Nejad, Hadi Beitollahi
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引用次数: 0
摘要
背景和目的：叶酸具有多种生物学功能，因此在临床实验室中对其进行灵敏的分析测定是很重要的。实验方法：基于二维过渡金属二硫族化合物MoS2修饰的碳离子液体糊电极（MoS2 CILPE），成功制备了一种简单的叶酸传感器。通过循环伏安法（CV）、微分脉冲伏安法（DPV）和计时电流法研究了所制备的电极的电化学性能。关键结果：使用CV，所制备的传感器对叶酸显示出优异的电活性。在最佳条件下（0.1 M PBS（pH 7.0）），DPV氧化峰值电流与叶酸浓度在5.0μM至100.0μM范围内成比例，估计检测限为1.0μM，定量限为5.0μM。结论：通过检测叶酸片和尿样中的叶酸，证明了传感器的常规分析能力，具有明显的回收价值。
Development of a highly sensitive voltammetric sensor for the detection of folic acid by using MoS2 and ionic liquid-modified carbon paste electrode.
Background and purpose: Sensitive analytical determination of folic acid is important in clinical laboratories due to its versatile biological functions.
Experimental approach: A simple folic acid sensor was successfully fabricated based on two-dimensional transition metal dichalcogenide MoS2 modified carbon ionic liquid paste electrode (MoS2-CILPE). The electrochemical properties of the fabricated electrode were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry.
Key results: The fabricated sensor displayed excellent electroactivity towards folic acid using CV. Under optimal conditions (0.1 M PBS (pH 7.0)), the DPV oxidation peak current was proportional to folic acid concentration in the range from 5.0 μM to 100.0 μM with an estimated limit of detection of 1.0 μM and limit of quantification of 5.0 μM.
Conclusion: The ability of the sensor for routine analyses was demonstrated by the detection of folic acid present in folic acid tablets and urine samples with appreciable recovery values.
期刊介绍：
ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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