靶向癌症中失调剪接因子:从RBM10缺乏中吸取的经验教训。

IF 5.3 2区 生物学 Q2 CELL BIOLOGY Journal of Molecular Cell Biology Pub Date : 2024-04-04 DOI:10.1093/jmcb/mjad063
Yongbo Wang, Zefeng Wang
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引用次数: 0

摘要

RNA剪接失调被认为是癌症的分子标志和重要的治疗靶点。虽然靶向剪接已被广泛用于癌症治疗,但通常缺乏失调剪接因子的特异性调节剂。RNA结合基序蛋白10(RBM10)在多种癌症中经常发生突变,特别是肺腺癌。越来越多的证据表明,功能缺失突变或异常表达导致的RBM10缺乏会导致癌症的发展、进展和治疗反应。在此,我们总结了癌症RBM10缺乏的功能后果和新的治疗意义。以RBM10为代表,我们强调了主要策略,并讨论了靶向癌症治疗中失调剪接因子的考虑因素。这些策略单独或与目前批准的疗法相结合可能在癌症治疗中具有巨大的前景。
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Targeting dysregulated splicing factors in cancer: lessons learned from RBM10 deficiency.
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来源期刊
CiteScore
9.60
自引率
1.80%
发文量
1383
期刊介绍: The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.
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