口腔鳞状细胞癌中铜中毒的景观和免疫模式。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-10-12 DOI:10.1111/jop.13489

Dong Yuan, Xin-Qiang Li, Fang-wen Qu, Yue Wang

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引用次数: 0

摘要

背景：口腔鳞状细胞癌是一种日益流行的癌症类型，其发病率和死亡率较高。其早期检测具有挑战性，主要是因为缺乏早期分子标记。杯状细胞病是一种新的细胞死亡调控机制，与各种癌症有关。在本研究中，我们旨在研究口腔鳞状细胞癌中铜中毒相关基因，以确定其预后价值。方法：通过分析基因组、大量RNA-seq和单细胞RNA-seq数据，我们研究了癌症基因组Atlas-Oral鳞状细胞癌数据集和基因表达综合库（GSE172577）中的13个铜中毒相关基因。结果：ATP7A、ATP7B和DLST是最常见的突变基因，其中9个基因与总生存率相关。对口腔鳞状细胞癌中铜中毒相关肿瘤细胞进行了单细胞分析，根据铜中毒相关基因的表达揭示了两种不同的模式。这些模式在基因改变和肿瘤免疫微环境方面表现出差异。最后，我们使用基于铜中毒模式相关基因的随机森林算法开发了铜中毒指数，其中较高的水平与较差的预后有关。结论：我们的研究结果为口腔鳞状细胞癌相关铜中毒的机制提供了有价值的见解。

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Landscape and the immune patterns of cuproptosis in oral squamous cell carcinoma

Background

Oral squamous cell carcinoma is an increasingly prevalent cancer type characterized by high incidence and mortality rates. Its early detection is challenging, primarily because of the absence of early molecular markers. Cuproptosis is a novel regulatory mechanism of cell death with implications in various cancers. In this study, we aimed to study cuproptosis-related genes in oral squamous cell carcinoma to identify their prognostic value.

Methods

By analyzing genomic, bulk RNA-seq, and single-cell RNA-seq data, we investigated 13 cuproptosis-related genes in The Cancer Genome Atlas-Oral Squamous Cell Carcinoma dataset and Gene Expression Omnibus repository (GSE172577).

Results

ATP7A, ATP7B, and DLST were the most frequently mutated genes, with nine of our studied genes associated with overall survival. Single-cell analysis was conducted to identify cuproptosis-related tumor cells in oral squamous cell carcinoma, which revealed two distinct patterns based on the expression of cuproptosis-related genes. These patterns exhibit differences in genetic alterations and tumor immune microenvironment. Finally, we developed a cuproptosis index using a random forest algorithm based on cuproptosis pattern-related genes in which higher levels were linked to poorer prognosis.