在克罗恩病中，饮食和共生酵母驱动异常的T细胞反应。

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Medicine Pub Date : 2023-10-11 DOI:10.1038/s41591-023-02559-2

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引用次数: 0

摘要

肠道微生物组的异常免疫反应已成为慢性肠道炎症的主要诱因，但参与炎症性肠病的微生物种类仍不清楚。我们的研究发现，肠道中的膳食酵母菌和共生酵母菌会促使一些具有细胞毒性效应功能的交叉反应型 CD4+ 1 型辅助 T 细胞扩增，这可能会导致克罗恩病患者的免疫病理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dietary and commensal yeasts drive aberrant T cell responses in Crohn’s disease

Aberrant immune responses to the intestinal microbiome have emerged as major contributors to chronic intestinal inflammation, but the microbial species involved in inflammatory bowel diseases remain unknown. Our study identified dietary and commensal yeasts of the gut that drive the expansion of some cross-reactive CD4+ type 1 helper T cells with cytotoxic effector functions, which potentially contributes to immunopathology in patients with Crohn’s disease.

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.