César Serrano, Sara Rothschild, Guillermo Villacampa, Michael C. Heinrich, Suzanne George, Jean-Yves Blay, Jason K. Sicklick, Gary K. Schwartz, Sameer Rastogi, Robin L. Jones, Piotr Rutkowski, Neeta Somaiah, Víctor Navarro, Denisse Evans, Jonathan C. Trent
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Rethinking placebos: embracing synthetic control arms in clinical trials for rare tumors
External comparator arms should be used when investigating novel therapies for gastrointestinal stromal tumor and other rare tumors to facilitate drug testing and regulatory approvals.
期刊介绍：
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
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Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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