Yue Song, Qi-Yang Li, Meng-Jing Cong, Xiao-Yan Pang, Bo Chen, Yong-Hong Liu, Li Liao, Jun-Feng Wang
{"title":"北极诺卡氏病SCSIO502F的细胞毒性吩嗪和抗变态反应吩恶嗪生物碱。","authors":"Yue Song, Qi-Yang Li, Meng-Jing Cong, Xiao-Yan Pang, Bo Chen, Yong-Hong Liu, Li Liao, Jun-Feng Wang","doi":"10.1007/s13659-023-00408-w","DOIUrl":null,"url":null,"abstract":"<div><p>Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (<b>1</b> and <b>2</b>) and one new phenoxazine (<b>3</b>) were isolated from <i>Nocardiopsis dassonvillei</i> 502F, a strain originally isolated from Arctic deep-sea sediments. AntiSMASH analysis of the genome of <i>Nocardiopsis dassonvillei</i> 502F revealed the presence of 16 putative biosynthetic gene clusters (BGCs), including a phenazine BGC. Most of the isolated compounds were evaluated for their antibacterial, antiallergic, and cytotoxic activities. Among them, compounds <b>4</b> and <b>5</b> exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC<sub>50</sub> values 0.16 and 20.0 μM, respectively. Besides, the results of antiallergic activities of compounds <b>6</b>–<b>8</b> exhibited inhibitory activities with IC<sub>50</sub> values of 10.88 ± 3.05, 38.88 ± 3.29, and 2.44 ± 0.17 μg/mL, respectively (IC<sub>50</sub> 91.6 μM for the positive control loratadine).</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581944/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F\",\"authors\":\"Yue Song, Qi-Yang Li, Meng-Jing Cong, Xiao-Yan Pang, Bo Chen, Yong-Hong Liu, Li Liao, Jun-Feng Wang\",\"doi\":\"10.1007/s13659-023-00408-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (<b>1</b> and <b>2</b>) and one new phenoxazine (<b>3</b>) were isolated from <i>Nocardiopsis dassonvillei</i> 502F, a strain originally isolated from Arctic deep-sea sediments. AntiSMASH analysis of the genome of <i>Nocardiopsis dassonvillei</i> 502F revealed the presence of 16 putative biosynthetic gene clusters (BGCs), including a phenazine BGC. Most of the isolated compounds were evaluated for their antibacterial, antiallergic, and cytotoxic activities. Among them, compounds <b>4</b> and <b>5</b> exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC<sub>50</sub> values 0.16 and 20.0 μM, respectively. Besides, the results of antiallergic activities of compounds <b>6</b>–<b>8</b> exhibited inhibitory activities with IC<sub>50</sub> values of 10.88 ± 3.05, 38.88 ± 3.29, and 2.44 ± 0.17 μg/mL, respectively (IC<sub>50</sub> 91.6 μM for the positive control loratadine).</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2023-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581944/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-023-00408-w\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-023-00408-w","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F
Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (1 and 2) and one new phenoxazine (3) were isolated from Nocardiopsis dassonvillei 502F, a strain originally isolated from Arctic deep-sea sediments. AntiSMASH analysis of the genome of Nocardiopsis dassonvillei 502F revealed the presence of 16 putative biosynthetic gene clusters (BGCs), including a phenazine BGC. Most of the isolated compounds were evaluated for their antibacterial, antiallergic, and cytotoxic activities. Among them, compounds 4 and 5 exhibited potent in vitro cytotoxic activities against osteosarcoma cell line 143B with IC50 values 0.16 and 20.0 μM, respectively. Besides, the results of antiallergic activities of compounds 6–8 exhibited inhibitory activities with IC50 values of 10.88 ± 3.05, 38.88 ± 3.29, and 2.44 ± 0.17 μg/mL, respectively (IC50 91.6 μM for the positive control loratadine).
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