近红外光免疫疗法和抗癌免疫。

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2024-02-14 DOI:10.1093/intimm/dxad042
Kohei Nakajima, Mikako Ogawa
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引用次数: 0

摘要

激活抗癌免疫系统是控制癌症的重要策略。一种新型癌症光疗法,近红外光免疫疗法(NIR-PIT)于2020年获准临床使用,使用IRDye®700DX(IR700)-结合抗体和近红外光。在用近红外光照射后,抗体-IR700缀合物在靶细胞的质膜上形成不溶于水的聚集体。这种聚集会对质膜造成致命损伤,并有效地导致免疫原性细胞死亡(ICD)。随后,ICD激活抗癌免疫细胞,例如树突细胞和细胞毒性T细胞。免疫检查点阻断联合治疗协同提高了NIR-PIT的抗癌效果。此外,NIR-PIT可以通过使用针对调节性T细胞和骨髓来源的抑制细胞的特异性抗体来消除光照射肿瘤中的免疫抑制免疫细胞。除了癌细胞靶向NIR-PIT外,这种免疫细胞靶向的NIR-PIT通过激活抗癌免疫系统显示出有希望的结果。此外,NIR-PIT可以通过仅消除肿瘤中的靶向细胞来操纵肿瘤微环境,因此它也可以用于深入了解基础研究中的免疫。
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Near-infrared photoimmunotherapy and anti-cancer immunity.

The activation of the anti-cancer immune system is an important strategy to control cancer. A new form of cancer phototherapy, near-infrared photoimmunotherapy (NIR-PIT), was approved for clinical use in 2020 and uses IRDye® 700DX (IR700)-conjugated antibodies and NIR light. After irradiation with NIR light, the antibody-IR700 conjugate forms water-insoluble aggregations on the plasma membrane of target cells. This aggregation causes lethal damage to the plasma membrane, and effectively leads to immunogenic cell death (ICD). Subsequently, ICD activates anti-cancer immune cells such as dendritic cells and cytotoxic T cells. Combination therapy with immune-checkpoint blockade has synergistically improved the anti-cancer effects of NIR-PIT. Additionally, NIR-PIT can eliminate immunosuppressive immune cells in light-irradiated tumors by using specific antibodies against regulatory T cells and myeloid-derived suppressor cells. In addition to cancer-cell-targeted NIR-PIT, such immune-cell-targeted NIR-PIT has shown promising results by activating the anti-cancer immune system. Furthermore, NIR-PIT can be used to manipulate the tumor microenvironment by eliminating only targeted cells in the tumor, and thus it also can be used to gain insight into immunity in basic research.

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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
期刊最新文献
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