卤代抗菌剂对抗耐药病原体。

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological Reviews Pub Date : 2023-12-15 DOI:10.1124/pharmrev.123.000863
Olajide Sunday Faleye, Bharath Reddy Boya, Jin-Hyung Lee, Inho Choi, Jintae Lee
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引用次数: 0

摘要

抗微生物耐药性给我们带来了潜在的全球危机,因为它破坏了传统抗生素对抗病原微生物的能力。抗微生物剂的历史充满了含有卤素的支架的例子。在这篇综述中,我们讨论了卤素原子在各种抗生素类型和抗菌支架中的影响及其作用模式、构效关系,以及卤素原子在抗菌活性和耐药性中的贡献。综述了其他卤代分子,包括碳水化合物、肽、脂质和聚合物复合物,并介绍了卤代支架对药代动力学、药效学的影响,以及影响抗菌和抗病毒活性的因素。此外,还讨论了卤化以规避抗微生物耐药性和恢复无效抗生素活力的潜力。这篇综述概述了卤化的意义、卤素在生物分子环境中相互作用、增强药理学特性的能力及其在预防后抗生素时代中的潜在治疗用途。重要意义声明抗生素耐药性和日益严重的抗生素无能是对全球健康的严重威胁。卤素原子在抗菌药物支架中的作用和重要性已经确定,但对其对耐药性和抗毒力的药理学影响知之甚少。这篇综述首次广泛评估了卤素原子在各种抗生素类别和药理学支架中的作用,并概述了它们克服耐药性的能力。
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Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens.

Antimicrobial resistance presents us with a potential global crisis as it undermines the abilities of conventional antibiotics to combat pathogenic microbes. The history of antimicrobial agents is replete with examples of scaffolds containing halogens. In this review, we discuss the impacts of halogen atoms in various antibiotic types and antimicrobial scaffolds and their modes of action, structure-activity relationships, and the contributions of halogen atoms in antimicrobial activity and drug resistance. Other halogenated molecules, including carbohydrates, peptides, lipids, and polymeric complexes, are also reviewed, and the effects of halogenated scaffolds on pharmacokinetics, pharmacodynamics, and factors affecting antimicrobial and antivirulence activities are presented. Furthermore, the potential of halogenation to circumvent antimicrobial resistance and rejuvenate impotent antibiotics is addressed. This review provides an overview of the significance of halogenation, the abilities of halogens to interact in biomolecular settings and enhance pharmacological properties, and their potential therapeutic usages in preventing a postantibiotic era. SIGNIFICANCE STATEMENT: Antimicrobial resistance and the increasing impotence of antibiotics are critical threats to global health. The roles and importance of halogen atoms in antimicrobial drug scaffolds have been established, but comparatively little is known of their pharmacological impacts on drug resistance and antivirulence activities. This review is the first to extensively evaluate the roles of halogen atoms in various antibiotic classes and pharmacological scaffolds and to provide an overview of their ability to overcome antimicrobial resistance.

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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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