Abdulrahman Ismaiel, Louis Birkhahn, Daniel-Corneliu Leucuta, Nahlah Al Srouji, Stefan-Lucian Popa, Dan L Dumitrascu
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引用次数: 0
摘要
介绍。最近对几种脂肪因子与COVID-19严重程度之间的关系进行了评估，结果尚无定论。因此，我们旨在评估COVID-19中脂肪因子与其严重程度之间的关系。方法。使用预定义的关键字在PubMed、Scopus和Embase中执行搜索。纽卡斯尔渥太华量表(NOS)用于纳入研究的质量评估。主要总结结果是脂肪因子水平的平均差异(MD)。结果。共纳入8项研究，涉及473人。在轻度与重度COVID-19患者中，血清脂联素水平存在显著MD (-5.734 [95% CI -11.215 - -0.252])，而在轻度与中度(-7.117 [95% CI -19.546 - 5.313])或中度与重度COVID-19患者(-1.846 [95% CI -4.516 - 0.824])中，血清脂联素水平无显著MD。此外，在比较COVID-19患者与对照组的脂联素和瘦素水平时，未发现显著MD(分别为-12.675 [95% CI -36.159 - 10.808])和(8.034 [95% CI -10.403 - 26.471])。结论。与轻度COVID-19患者相比，重度患者的脂联素水平显著升高。然而，在轻度与中度、中度与重度COVID-19患者的脂联素水平、COVID-19患者的脂联素和瘦素水平与对照组相比均未发现显著MD。
Are adipokines related to COVID-19 and its severity? A systematic review and meta-analysis.
Introduction: The relationship between several adipokines and COVID-19 severity has lately been evaluated, results being inconclusive. Therefore, we aimed to assess the association between adipokines in COVID-19 and its severity.
Methods: A search was performed in PubMed, Scopus, and Embase using predefined keywords. The Newcastle of Ottawa Scale (NOS) was used for the quality assessment of included studies. The main summary outcome was the mean difference (MD) in adipokine levels.
Results: A total of 8 studies involving 473 individuals were included. A significant MD in serum adiponectin levels was demonstrated in mild vs. severe COVID-19 patients (-5.734 [95% CI -11.215 - -0.252]), with no significant MD in mild vs. moderate (-7.117 [95% CI -19.546 - 5.313]), or moderate vs. severe COVID-19 (-1.846 [95% CI -4.516 - 0.824]). Moreover, no significant MD was found in adiponectin and leptin levels when comparing COVID-19 patients vs. controls (-12.675 [95% CI -36.159 - 10.808]) and (8.034 [95% CI -10.403 - 26.471]), respectively.
Conclusion: Adiponectin levels were significantly increased in patients with severe compared to mild COVID-19. However, no significant MD was found in adiponectin levels in mild vs. moderate and moderate vs. severe COVID-19 patients, nor in adiponectin and leptin levels in COVID-19 patients vs. controls.
期刊介绍：
Geophysical Research Letters (GRL) publishes high-impact, innovative, and timely research on major scientific advances in all the major geoscience disciplines. Papers are communications-length articles and should have broad and immediate implications in their discipline or across the geosciences. GRLmaintains the fastest turn-around of all high-impact publications in the geosciences and works closely with authors to ensure broad visibility of top papers.
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