A. Alfadil, Hamoud Alsamhan, A. Ali, H. Alkreathy, Mohammad W. Alrabia, Hani Abdullah
{"title":"2,3-二甲基喹啉的体内外抗真菌活性研究","authors":"A. Alfadil, Hamoud Alsamhan, A. Ali, H. Alkreathy, Mohammad W. Alrabia, Hani Abdullah","doi":"10.9734/JPRI/2021/V33I31A31684","DOIUrl":null,"url":null,"abstract":"Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline. Study Design: A preclinical study of a compound against 10 fungal species. Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals. Methodology: We evaluated the susceptibility of 2,3-dimethylquinoxaline in vitro against a wide range of pathogenic fungi, including six Candida species, two Aspergillus species, one Cryptococcus species, and one Trichophyton species. Also, we evaluated the susceptibility of 2,3dimethylquinoxaline in vivo against oral candidiasis using a mice model. Original Research Article Alfadil et al.; JPRI, 33(31A): 198-207, 2021; Article no.JPRI.69458","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vivo and In vitro Antifungal Activity of 2,3-Dimethylquinoxline\",\"authors\":\"A. Alfadil, Hamoud Alsamhan, A. Ali, H. Alkreathy, Mohammad W. Alrabia, Hani Abdullah\",\"doi\":\"10.9734/JPRI/2021/V33I31A31684\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline. Study Design: A preclinical study of a compound against 10 fungal species. Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals. Methodology: We evaluated the susceptibility of 2,3-dimethylquinoxaline in vitro against a wide range of pathogenic fungi, including six Candida species, two Aspergillus species, one Cryptococcus species, and one Trichophyton species. Also, we evaluated the susceptibility of 2,3dimethylquinoxaline in vivo against oral candidiasis using a mice model. Original Research Article Alfadil et al.; JPRI, 33(31A): 198-207, 2021; Article no.JPRI.69458\",\"PeriodicalId\":16706,\"journal\":{\"name\":\"Journal of Pharmaceutical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.9734/JPRI/2021/V33I31A31684\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.9734/JPRI/2021/V33I31A31684","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vivo and In vitro Antifungal Activity of 2,3-Dimethylquinoxline
Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline. Study Design: A preclinical study of a compound against 10 fungal species. Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals. Methodology: We evaluated the susceptibility of 2,3-dimethylquinoxaline in vitro against a wide range of pathogenic fungi, including six Candida species, two Aspergillus species, one Cryptococcus species, and one Trichophyton species. Also, we evaluated the susceptibility of 2,3dimethylquinoxaline in vivo against oral candidiasis using a mice model. Original Research Article Alfadil et al.; JPRI, 33(31A): 198-207, 2021; Article no.JPRI.69458
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
