Gavin J. Gibson受邀在2021年6月11日皇家统计学会2019冠状病毒病传播专题会议第二届会议上对论文进行讨论

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-12-13 DOI:10.1111/rssa.12972
Gavin J. Gibson
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引用次数: 0

摘要

我祝贺这两个团队在模拟Covid-19大流行方面做出的可喜贡献。在严格的时间尺度内产生如此高质量的结果是一项真正的成就。两项研究都通过构建层次贝叶斯框架,从汇总数据中推断出时变的再现数R t $$ {R}_t $$R t $$ {R}_t $$作为内在参数。观察结果是自回归感染过程的噪声时移表示,其权重由代时间概率指定,并由R t $$ {R}_t $$调节。与Flaxman等人(2020)的共同根源,这两篇论文在处理时间效应和空间耦合方面有所不同(Teh等人(2022)对log R t采用了明确的时空高斯过程$$ \log {R}_t $$,而Mishra等人则采用了不同的方法。(2022)使用随机漫步先验),在数据的使用和潜在的假设中。在R t $$ {R}_t $$之前的研究中,这两项研究都没有纳入可预见的影响,例如干预后的阶跃变化,改进测试对跟踪和跟踪措施的影响,或R t $$ {R}_t $$由于易感耗竭的预期下降。顺便提一下,Mishra等人(2022)对感染模型的描述似乎令人困惑,方程(1)和(2)之间的R t $$ {R}_t $$从瞬时繁殖数变为“原始”繁殖数,随后由报告前的敏感比例重新缩放。论文的一般方法可以说是“图像分析师对流行病建模的看法”,其目标是从噪声图像中恢复“真实”的R t $$ {R}_t $$,先验分布提供正则化,而不是捕获机械思维。这种方法不同于植物或动物病原体建模者经常采用的方法,后者旨在估计控制传播过程不同方面的参数,例如接触率和空间核函数,然后将“机制”理解外推到其他环境。R t $$ {R}_t $$这个可以定义的量是传播过程和假定的监测和控制策略的副产品,而不是一个内在参数。 , 2019)?例如,当模拟具有繁殖矩阵R t $$ {\mathbf{R}}_t $$的结构化种群的类似数据时,输入的R t $$ {R}_t $$能成功地跟踪真实R的最大特征值吗T $$ {\mathbf{R}}_t $$,或者它可能低估了这个数量,因为组间的感染分布可能与相应的特征向量不匹配?与更简单的平滑方法进行比较也是受欢迎的。这两篇论文强调了流行病统计建模的一个重要挑战——对更复杂的机制模型的统计推断,这些模型可能为有针对性的控制策略的设计提供信息。这就要求可用数据的丰富程度与模型的复杂性更好地匹配;实现这样的匹配本身就是一个重大挑战。这些论文的作者有效地利用了现有数据,他们的建模是理解空间相互作用影响的重要一步。探索他们的框架是否延伸到其他异质性将是有趣的,例如年龄结构引起的异质性,其重要性在其他研究中已经得到强调(例如Lau等人,2020)。
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Gavin J. Gibson's invited discussion contribution to the papers in Session 2 of the Royal Statistical Society's Special Topic Meeting on Covid-19 Transmission: 11 June 2021
I congratulate both teams for these welcome contributions on modelling the Covid-19 pandemic. To produce results of such quality within exacting timescales is a genuine achievement. Both studies infer a time-varying reproduction number R t from summary data by construct-ing hierarchical Bayesian frameworks embodying R t as an intrinsic parameter. Observations arise as noisy, time-shifted representations of an autoregressive infection process with weights specified by generation-time probabilities and moderated by R t . With a common root in Flaxman et al. (2020), the papers differ in their treatment of temporal effects and spatial cou-pling (with Teh et al. (2022) adopting an explicitly spatio-temporal Gaussian process for log R t while Mishra et al. (2022) use a random walk prior), in their use of data, and in underlying assumptions. Neither study, in the prior for R t , incorporates foreseeable effects such as step changes follow-ing interventions, the impact of improved testing on track-and-trace measures, or the expected decline in R t due to susceptible depletion. Incidentally, the presentation of the infection model in Mishra et al. (2022) seems confusing, with R t between equations (1) and (2) changing from an instantaneous reproduction number to a ‘raw’ reproduction number, subsequently re-scaled by the susceptible proportion before reporting. The papers’ general approach is arguably the ‘image analyst’s take’ on epidemic modelling, where the objective is to recover a ‘true’ R t from a noisy image, with prior distributions providing regularisation rather than capturing mechanistic thinking. This approach differs
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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