Hong Minli , Huang Baopei , Hong Chunlin , Chen Huinuan , Chen Wenxi , Liu Chaohui , Li Xinjian , Li Candong
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Finally, CRS was evaluated before and after treatment of PIC patients in the experimental group.</p></div><div><h3>RESULTS</h3><p>Fifty-two patients in the experimental group and fifty control patients completed the study. Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment, however cough symptoms in the experimental group 1 (0, 2) were significantly lower than the control group 2 (1, 2) after treatment (<em>P</em> < 0.05). Similarly, TCM symptom scores 4 (0, 7) in the experimental group were significantly lower than the control group 6 (3, 12) (<em>P</em> < 0.01). Overall, the effective rate of the experimental treatment (84.60%) was significantly higher than that of the control treatment (68.00%) (<em>P</em> < 0.01). The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2 (2,3) d vs 3 (2,3) d, <em>P</em> < 0.01]. The relapse rate in the experimental group (9.09%) was lower than that of the control group (29.41%) (<em>P</em> < 0.05). 39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment. The lgC2 and lgC5 of the experimental group prior to treatment was 1.19 (0.59, 1.49) and 1.80 (1.49, 2.10), respectively. The lgC2, lgC5 of the healthy control group was 1.49 (0.89, 2.40) and 2.70 (2.40, 3.00), respectively. The differences in lgC2 and lgC5 between experimental group and healthy groups were significant at this time point (both <em>P</em> < 0.01). After treatment, 34 patients in the experimental group received re-examination. lgC5 increased from 1.80 (1.49, 2.10) to 2.10 (1.49, 3.00). CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group (<em>P</em> <0.05).</p></div><div><h3>CONCLUSION</h3><p>CJSD could effectively improve the clinical symptoms of PIC patients, with demonstrable low recurrence and safety. CJSD also significantly decreased the CRS in patients with PIC.</p></div>","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"38 4","pages":"Pages 610-617"},"PeriodicalIF":2.0000,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0254-6272(18)30894-X","citationCount":"1","resultStr":"{\"title\":\"Efficacy of Chaihu Jisang decoction on post-infection cough and its effect on cough reflex sensitivity\",\"authors\":\"Hong Minli , Huang Baopei , Hong Chunlin , Chen Huinuan , Chen Wenxi , Liu Chaohui , Li Xinjian , Li Candong\",\"doi\":\"10.1016/S0254-6272(18)30894-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVE</h3><p>To investigate the efficacy of Chaihu Ji Sang Decoction (CJSD), (a modification of Xiao Chaihu Tang (Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough (PIC). Its effect on cough reflex sensitivity (CRS) was also described.</p></div><div><h3>METHODS</h3><p>One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group (54 patients in each group). The experimental group was given CJSD orally, and the control group was given cetirizine hydrochloride for 7 d. Cough symptom scores and TCM symptom scores were compared before and after treatment. Efficacy, cough onset time, recurrence, and adverse drug reactions were additionally evaluated. Finally, CRS was evaluated before and after treatment of PIC patients in the experimental group.</p></div><div><h3>RESULTS</h3><p>Fifty-two patients in the experimental group and fifty control patients completed the study. Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment, however cough symptoms in the experimental group 1 (0, 2) were significantly lower than the control group 2 (1, 2) after treatment (<em>P</em> < 0.05). Similarly, TCM symptom scores 4 (0, 7) in the experimental group were significantly lower than the control group 6 (3, 12) (<em>P</em> < 0.01). Overall, the effective rate of the experimental treatment (84.60%) was significantly higher than that of the control treatment (68.00%) (<em>P</em> < 0.01). The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2 (2,3) d vs 3 (2,3) d, <em>P</em> < 0.01]. The relapse rate in the experimental group (9.09%) was lower than that of the control group (29.41%) (<em>P</em> < 0.05). 39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment. The lgC2 and lgC5 of the experimental group prior to treatment was 1.19 (0.59, 1.49) and 1.80 (1.49, 2.10), respectively. The lgC2, lgC5 of the healthy control group was 1.49 (0.89, 2.40) and 2.70 (2.40, 3.00), respectively. The differences in lgC2 and lgC5 between experimental group and healthy groups were significant at this time point (both <em>P</em> < 0.01). After treatment, 34 patients in the experimental group received re-examination. lgC5 increased from 1.80 (1.49, 2.10) to 2.10 (1.49, 3.00). CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group (<em>P</em> <0.05).</p></div><div><h3>CONCLUSION</h3><p>CJSD could effectively improve the clinical symptoms of PIC patients, with demonstrable low recurrence and safety. 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引用次数: 1
摘要
目的观察柴胡积桑汤(柴胡小汤加味)治疗感染后咳嗽(PIC)的疗效。对咳嗽反射敏感性(CRS)的影响也作了描述。方法118例PIC患者随机分为实验组和对照组(每组54例)。试验组患者口服CJSD,对照组患者口服盐酸西替利嗪,疗程7 d。比较治疗前后咳嗽症状评分和中医症状评分。另外评估疗效、咳嗽发作时间、复发情况和药物不良反应。最后对实验组PIC患者治疗前后的CRS进行评价。结果实验组52例,对照组50例。治疗后两组患者咳嗽症状评分及中医症状评分均有显著改善,但实验组1(0,2)治疗后咳嗽症状明显低于对照组2 (1,2)(P <0.05)。同样,实验组中医症状评分4(0,7)明显低于对照组6 (3,12)(P <0.01)。总体而言,试验组有效率(84.60%)显著高于对照组(68.00%)(P <0.01)。实验处理的起效时间比对照处理快1天[2 (2,3)d vs 3 (2,3) d, P <0.01]。实验组复发率(9.09%)低于对照组(29.41%)(P <0.05)。试验组39例PIC患者在治疗前完成辣椒素咳嗽刺激试验。实验组治疗前lgC2和lgC5分别为1.19(0.59,1.49)和1.80(1.49,2.10)。健康对照组lgC2、lgC5分别为1.49(0.89、2.40)、2.70(2.40、3.00)。实验组与健康组在此时间点lgC2、lgC5差异均有统计学意义(P <0.01)。治疗后,实验组34例患者复查。lgC5从1.80(1.49,2.10)增加到2.10(1.49,3.00)。实验组治疗/复查后CRS均显著低于基线(P <0.05)。结论cjsd能有效改善PIC患者的临床症状,具有明显的低复发率和安全性。CJSD也显著降低了PIC患者的CRS。
Efficacy of Chaihu Jisang decoction on post-infection cough and its effect on cough reflex sensitivity
OBJECTIVE
To investigate the efficacy of Chaihu Ji Sang Decoction (CJSD), (a modification of Xiao Chaihu Tang (Minor Decoction of Bupleurum) was evaluated in patients with post-infection cough (PIC). Its effect on cough reflex sensitivity (CRS) was also described.
METHODS
One hundred and eighteen patients with PIC were enrolled and randomly divided into an experimental group and control group (54 patients in each group). The experimental group was given CJSD orally, and the control group was given cetirizine hydrochloride for 7 d. Cough symptom scores and TCM symptom scores were compared before and after treatment. Efficacy, cough onset time, recurrence, and adverse drug reactions were additionally evaluated. Finally, CRS was evaluated before and after treatment of PIC patients in the experimental group.
RESULTS
Fifty-two patients in the experimental group and fifty control patients completed the study. Cough symptom scores and the TCM symptom scores of the two groups were significantly improved after treatment, however cough symptoms in the experimental group 1 (0, 2) were significantly lower than the control group 2 (1, 2) after treatment (P < 0.05). Similarly, TCM symptom scores 4 (0, 7) in the experimental group were significantly lower than the control group 6 (3, 12) (P < 0.01). Overall, the effective rate of the experimental treatment (84.60%) was significantly higher than that of the control treatment (68.00%) (P < 0.01). The onset time of efficacy of the experimental treatment was one day faster than the control treatment [2 (2,3) d vs 3 (2,3) d, P < 0.01]. The relapse rate in the experimental group (9.09%) was lower than that of the control group (29.41%) (P < 0.05). 39 PIC patients in the experimental group completed a capsaicin cough challenge test before treatment. The lgC2 and lgC5 of the experimental group prior to treatment was 1.19 (0.59, 1.49) and 1.80 (1.49, 2.10), respectively. The lgC2, lgC5 of the healthy control group was 1.49 (0.89, 2.40) and 2.70 (2.40, 3.00), respectively. The differences in lgC2 and lgC5 between experimental group and healthy groups were significant at this time point (both P < 0.01). After treatment, 34 patients in the experimental group received re-examination. lgC5 increased from 1.80 (1.49, 2.10) to 2.10 (1.49, 3.00). CRS after treatment/re-examination was significantly lower than those of baseline in the experimental group (P <0.05).
CONCLUSION
CJSD could effectively improve the clinical symptoms of PIC patients, with demonstrable low recurrence and safety. CJSD also significantly decreased the CRS in patients with PIC.
期刊介绍:
Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.