慢性精神压力诱导自然杀伤细胞和CD56dim亚群可逆减少

Manar M. Ismail
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摘要

一般来说,学习成为一名医疗保健提供者是一个压力大、要求高的领域,学生们必须面对许多可能影响他们总体健康状况的压力源,包括免疫系统。本研究旨在研究长期自然生活压力暴露对女性实验医学生外周血T淋巴细胞和自然杀伤细胞百分比的影响。抽取期末笔试最后一周(应激时间点)的52份外周血样本和休息12周后的27份样本(对照组),并通过流式细胞术进行分析。在应激时间点,随着辅助T细胞/T细胞毒性比的升高,辅助T细胞百分比显著升高,P值<0.001。此外,NK细胞和CD56dim的百分比显著较低,同时CD56bright亚群的百分比较高,P值<0.001。对患有普通感冒的亚组(34.6%)的淋巴细胞分析显示,T细胞毒性和NK细胞的数量显著减少,P值分别为0.042和0.001。这项研究得出的结论是,在人类中,学业考试中表现出的自然慢性压力有可能对免疫系统产生负面影响,但在采取足够的压力缓解措施后,会恢复正常。需要在更大、更多样的样本群体中复制,并包括男性进行比较。此外,未来的研究还需要评估NK细胞的细胞毒性和T辅助细胞亚群,尤其是T调节细胞。
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Chronic Mental Stress Induces Reversible Reduction of Natural Killer Cells and CD56dim Subpopulation
Generally, studying to be a health care provider is a stressful and demanding field and the students have to face many stressors that may affect their general health status including the immune system. This work aimed at studying the effect of prolonged naturalistic life-stress exposure on the percentage of peripheral blood T-lymphocytes and Natural Killer (NK) cells in female laboratory medicine students. 52 peripheral blood samples in the last week of the final written exam (stress time point) and 27 samples after 12 weeks rest (control) were withdrawn and analyzed by flow cytometry. At the stress time point, there was a significant high T helper cells percentage with elevation of T helper/T cytotoxic ratio, P value <0.001. Also, significant low percentages of NK cells and CD56dim  together with high CD56bright subpopoulations were detected, P value <0.001. Lymphocyte analysis of the subgroup that had an attach of common cold (34.6%) revealed significant reduction in the number of T cytotoxic and NK cells, P values 0.042 and 0.001 respectively. This study concluded that in humans, naturalistic chronic stress as expressed in academic exams has the potential to negatively affect the immune system, but normality is regained after sufficient stress relieve measures. Replication in larger and more diverse sample populations with inclusion of males for comparison is required, Also assessments of NK cell cytotoxicity and T helper cell subsets especially T regulatory cells are required for future studies.
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