认知康复治疗对南非农村儿童HIV疗效的可行性研究:持续关注

IF 1 Q4 PSYCHOLOGY Acta Neuropsychologica Pub Date : 2022-08-25 DOI:10.5604/01.3001.0016.0115
C. Basterfield, S. Zondo
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引用次数: 1

摘要

尽管联合抗逆转录病毒疗法(cART)取得了进展,但由于病毒穿过血脑屏障(BBB),撒哈拉以南非洲的儿童仍然存在神经认知缺陷。基于神经可塑性原则,我们的研究试图调查引入一种名为Brainwave-R的纸笔认知康复工具的可行性,以改善南非农村低社会经济背景儿童的艾滋病毒神经认知影响。五名艾滋病毒阳性儿童和六名艾滋病毒阴性儿童被分配到实验组或对照组。实验组使用Brainwave-R接受了两个月的认知康复治疗,以补救持续的注意力,而非接触对照组则参加了安慰剂活动。在干预训练课前后,使用持续注意力子测验,采取持续注意力措施。对照组在研究结束后三个月接受了认知干预。Mann-Whitney U检验显示,在认知康复干预后,实验组(Mdn=38.50)与对照组(Mdn=37.00)没有显著差异,U=12.00,z=-.55,p=0.66,r=-0.17。Wilcoxon符号秩检验发现,样本中HIV阳性参与者康复后,从测试前得分(Mdn=31.00)到测试后得分(Mdn=38.00)有显著改善,T=15.00,z=2.02,p=0.04,r=-0.90。我们的研究结果提高了用纸笔认知康复方法补充抗逆转录病毒(ARV)治疗儿科HIV的可行性。
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A FEASIBILITY STUDY EXPLORING THE EFFICACY OF COGNITIVE REHABILITATION THERAPY FOR PAEDIATRIC HIV IN RURAL SOUTH AFRICA: A FOCUS ON SUSTAINED ATTENTION
Despite advances in combination antiretroviral therapy (cARTs), children in Sub-Saharan Africa continue to experience neurocognitive deficits due to the virus crossing the blood-brain barrier (BBB). Based on the principles of neuroplasticity, our study sought to investigate the feasibility of introducing a pencil and paper cognitive rehabilitation tool called Brainwave-R, to ameliorate the effects of HIV neurocognition amongst children from a low socioeconomic background in rural South Africa. Five HIV positive and six HIV negative children were assigned to either an experimental or control group. The experimental group underwent two months of cognitive rehabilitation therapy to remediate sustained attention, using Brainwave-R, whereas the noncontact control group took part in placebo activities. Sustained attention measures were taken before and after the intervention training sessions, using a sustained attention subtest. The control group later received cognitive intervention three months following the conclusion of the research study. A Mann Whitney U Test revealed that the experimental group (Mdn=38.50) did not differ significantly from the control group (Mdn=37.00) after the cognitive rehabilitation intervention, U= 12.00, z= -.55, p= 0.66, r= -0.17. A Wilcoxon Signed Rank Test found that there was a significant improvement from pretest scores (Mdn=31.00) to post test scores (Mdn=38.00) following the rehabilitation for HIV positive participants in the sample, T=15.00, z = -2.02, p= 0.04, r= -0.90. The findings of our study raise the feasibility of a pencil and paper cognitive rehabilitation method to supplement antiretroviral (ARV) therapy in paediatric HIV.
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