曲克芦丁是一种生物类黄酮,可改善链脲佐菌素诱导的1型糖尿病大鼠血液中的氧化应激

Q4 Pharmacology, Toxicology and Pharmaceutics Iranian Journal of Pharmaceutical Sciences Pub Date : 2017-04-01 DOI:10.22034/IJPS.2017.31148
R. Badalzadeh, L. Chodari, V. Ghorbanzadeh
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引用次数: 3

摘要

1型糖尿病是一种慢性疾病,其特征是由于β细胞的破坏,身体无法产生胰岛素。越来越多的证据表明,活性氧(ROS)在糖尿病并发症的发展中起着重要作用。本研究的目的是研究曲克芦丁给药对STZ诱导的糖尿病大鼠血液中氧化应激标志物的影响。雄性Wistar大鼠分为4组:对照组(con)、对照曲克芦丁(con-TRX)、糖尿病组(Dia)、糖尿病曲克芦丁组(Dia-TRX)。通过注射链脲佐菌素(STZ)(i.p,55mg/kg)诱导1型糖尿病,并持续10周。动物接受曲克芦丁(150mg/kg)的口服给药4周。研究结束时,用分光光度法测定了丙二醛(MDA,脂质过氧化的主要产物)、抗氧化酶超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)和过氧化氢酶(CAT)的活性。与对照组相比,STZ诱导糖尿病导致MDA水平升高,血液抗氧化能力降低(P<0.05)。曲克芦丁预处理糖尿病大鼠与未处理糖尿病组相比,MDA水平显著降低(P<0.01),抗氧化酶SOD、GPX和CAT活性升高。曲克芦丁对非糖尿病大鼠无明显影响。这些发现表明曲克芦丁可以通过提高抗氧化酶活性和减少脂质过氧化来预防糖尿病的氧化并发症。
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Troxerutin, a bioflavonoid, improves oxidative stress in blood of streptozotocin-induced type-1 diabetic rats
Type 1 diabetes is a chronic disease characterized by the body's inability to produce insulin due to destruction of the beta cells. There is increasing evidence that reactive oxygen species (ROS) play a major role in the development of diabetic complications. The purpose of this study is to investigate the effects of troxerutin administration on oxidative stress markers in blood of STZ-induced diabetic rats. Male Wistar rats were divided into 4 groups as: control (con), control-troxerutin (CON-TRX), diabetes (Dia), diabetic-troxerutin (DIA-TRX). Type 1 diabetes was induced by injection of streptozotocin (STZ) (i.p, 55mg/kg) and lasted for 10 weeks. Animals were received oral administration of troxerutin (150 mg/kg) for 4 weeks. At the end of study, malondialdehyde (MDA, the main product of lipid peroxidation), activity of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) were measured spectrophotometrically. Induction of diabetes with STZ resulted in increased MDA levels and decreased blood antioxidant capacity as compared with those of controls (P<0.05). Pre-treatment of diabetic rats with troxerutin significantly decreased the levels of MDA (P<0.01) and increased the activity of antioxidant enzymes SOD, GPX and CAT compared to untreated-diabetic groups. Troxerutin had no significant influence on non-diabetic rats. These findings showed that troxerutin may prevent oxidative complications of diabetic circumstances by elevating antioxidant enzymes activities and reducing lipid peroxidation.
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来源期刊
Iranian Journal of Pharmaceutical Sciences
Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
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期刊介绍: Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.
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