A. Jarab, W. Al-Qerem, S. A. Abu Heshmeh, K. Alzoubi, T. Mukattash, A. Akour
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引用次数: 0
摘要
本研究旨在评估类风湿关节炎(RA)患者的疾病活动性,并探讨与疾病控制不良相关的因素。这项横断面研究是在约旦两所教学医院的风湿病门诊进行的。使用经验证的风湿病五项依从性问卷评估药物依从性,使用临床疾病活动性指数评分评估疾病活动性。通过有序回归来探讨与未控制RA相关的因素。大多数参与者(n=261)表现出中度至高度的疾病活动性(71.2%)。血清阴性RA (B=-0.882, CI [-1.584/-0.180], p<0.05)与疾病活动度降低显著相关,药物依从性不佳与RA控制不良显著相关(B=1.023, CI [0.289-1.756], p<0.01)。未来的研究应探讨与药物依从性不相关的因素。这些因素应该成为未来干预措施的目标,以改善RA的控制,特别是对疾病严重程度高的患者。
Disease control and its associated factors in outpatients with rheumatoid arthritis
The present study aimed to evaluate disease activity and explore the factors associated with poor disease control among patients with rheumatoid arthritis (RA). This cross-sectional study was conducted at outpatient rheumatology clinics in two teaching hospitals in Jordan. Medication adherence was assessed using the validated five-item compliance questionnaire for rheumatology, and disease activity was assessed using the clinical disease activity Index score. Ordinal regression was performed to explore the factors associated with uncontrolled RA. Most of the participants (n=261) demonstrated moderate to high disease activity (71.2%). Seronegative RA (B=-0.882, CI [-1.584/-0.180], p<0.05) was significantly associated with lower disease activity, while medication non-adherence was significantly associated with poor RA control (B=1.023, CI [0.289-1.756], p<0.01). Future research should explore the factors associated with medication non-adherence. These factors should be targeted in future interventions to improve RA control, particularly in patients who suffer from high disease severity.