乳糜泻儿童无麸质饮食对组织转谷氨酰胺酶抗体正常化的影响

IF 0.3 Q4 PEDIATRICS Journal of Child Science Pub Date : 2021-01-01 DOI:10.1055/s-0041-1724033
M. Ebrahimi, Hosein Alimadadi, M. Najafi, M. Vasei, P. Rahmani
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引用次数: 0

摘要

关于伊朗乳糜泻(CD)治疗的随访数据非常有限。本研究旨在探讨乳糜泻患者抗组织转谷氨酰胺酶(atTG)正常化间隔及相关因素。本回顾性研究纳入了德黑兰医科大学儿童医学中心的乳糜泻患者。记录初始atTG滴度和组织学评价(Marsh分级≥2)。在每次随访中评估atTG滴度,直到儿童严格采用无谷蛋白饮食的正常化时间。记录患者诊断时的年龄、性别、诊断时的Marsh分级、其他合并症、家族史,以确定这些因素与抗体正常化间隔的关系。研究共纳入71例患者,其中34例(47.89%)患者atTG水平低于20 U/mL,平均间隔31.36(±2.89)个月(95%可信区间:25.7-37.02)。抗体正常化间隔与不同年龄范围及Marsh分级无显著差异。Cox回归分析显示,性别、年龄范围、Marsh分级、CD家族史阳性、是否存在合并症并不能显著预测更长的抗体正常化时间间隔。
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Investigation of Tissue Transglutaminase Antibody Normalization in Response to Gluten-Free Diet in Children with Celiac Disease
Abstract A very limited amount of data are available regarding the follow-up of celiac disease (CD) treatment in Iran. The aim of this study is to investigate antitissue transglutaminase (atTG) normalization interval and the associated factors in CD patients. This retrospective study included CD patients enrolled in Children's Medical Center, Tehran University of Medical Sciences. The initial atTG titer and histological evaluation (with Marsh grade ≥2) were recorded. The atTG titer was assessed in each follow-up until the time of normalization where children were strictly on gluten-free diet. The age at the time of diagnosis, gender, Marsh grade at the time of diagnosis, other comorbidities, and family history of CD patients were recorded to determine the association of these factors with antibody normalization interval. In total, 71 patients were recruited in the study of which 34 (47.89%) subjects had atTG level below 20 U/mL at the average interval of 31.36 ( ±  2.89) months (95% confidence interval: 25.7–37.02). There was no significant difference between the antibody normalization interval and different age ranges and Marsh grade. Cox regression demonstrated that gender, age ranges, Marsh grade, positive family history of CD, and the presence of comorbidities did not significantly predict longer antibody normalization interval.
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