J. Mejia-Montilla , M. Álvarez-Mon , E. Reyna-Villasmil , D. Torres-Cepeda , N. Reyna-Villasmil , A. Fernández-Ramírez , A. Bravo-Henríquez
{"title":"Adiponectina plasmática en mujeres obesas y no obesas con síndrome de ovarios poliquísticos","authors":"J. Mejia-Montilla , M. Álvarez-Mon , E. Reyna-Villasmil , D. Torres-Cepeda , N. Reyna-Villasmil , A. Fernández-Ramírez , A. Bravo-Henríquez","doi":"10.1016/j.rprh.2017.10.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To determine plasma adiponectin concentrations in obese and non-obese women with polycystic ovary syndrome (PCOS).</p></div><div><h3>Materials and methods</h3><p>A Case control study was conducted on women with a diagnosis of PCOS and age-matched healthy controls, with regular menstruation and normal ultrasound ovaries, were selected. Participants were divided into four groups (Group A: PCOS and obese; Group B: PCOS and non-obese; Group C: obese controls, and Group D: non-obese controls) according to body mass index (obese ><!--> <!-->30<!--> <!-->kg/m<sup>2</sup> and non-obese <<!--> <!-->25<!--> <!-->kg/m<sup>2</sup>). Concentrations of sexual hormones, sex hormone-binding globulin, serum glucose, insulin, and adiponectin, were measured.</p></div><div><h3>Results</h3><p>Obese and non-obese women with PCOS had higher luteinising hormone, follicle stimulating hormone, androstenedione, testosterone, and insulin levels compared to women in the obese and non-obese control group, respectively (<em>P</em> <!--><<!--> <!-->.0001). Women with PCOS had a significantly lower concentration of adiponectin (Group A: 8.3<!--> <!-->±<!--> <!-->1.6<!--> <!-->ng/mL and Group B: 10.1<!--> <!-->±<!--> <!-->1.4<!--> <!-->ng/mL), compared with controls (Group C: 12.1<!--> <!-->±<!--> <!-->2.8<!--> <!-->ng/mL and Group D: 14.7<!--> <!-->±<!--> <!-->2.6<!--> <!-->ng/dL; <em>P</em> <!--><<!--> <!-->.0001). It was observed that adiponectin concentrations had a positive and significant association with fasting blood glucose and insulin in PCOS women (<em>P</em> <!--><<!--> <!-->.05).</p></div><div><h3>Conclusion</h3><p>There are significant differences in plasma adiponectin concentrations between obese and non-obese women with polycystic ovary syndrome and normal controls.</p></div>","PeriodicalId":32275,"journal":{"name":"Perinatologia y Reproduccion Humana","volume":"31 2","pages":"Pages 62-67"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rprh.2017.10.018","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Perinatologia y Reproduccion Humana","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0187533717300614","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Adiponectina plasmática en mujeres obesas y no obesas con síndrome de ovarios poliquísticos
Objective
To determine plasma adiponectin concentrations in obese and non-obese women with polycystic ovary syndrome (PCOS).
Materials and methods
A Case control study was conducted on women with a diagnosis of PCOS and age-matched healthy controls, with regular menstruation and normal ultrasound ovaries, were selected. Participants were divided into four groups (Group A: PCOS and obese; Group B: PCOS and non-obese; Group C: obese controls, and Group D: non-obese controls) according to body mass index (obese > 30 kg/m2 and non-obese < 25 kg/m2). Concentrations of sexual hormones, sex hormone-binding globulin, serum glucose, insulin, and adiponectin, were measured.
Results
Obese and non-obese women with PCOS had higher luteinising hormone, follicle stimulating hormone, androstenedione, testosterone, and insulin levels compared to women in the obese and non-obese control group, respectively (P < .0001). Women with PCOS had a significantly lower concentration of adiponectin (Group A: 8.3 ± 1.6 ng/mL and Group B: 10.1 ± 1.4 ng/mL), compared with controls (Group C: 12.1 ± 2.8 ng/mL and Group D: 14.7 ± 2.6 ng/dL; P < .0001). It was observed that adiponectin concentrations had a positive and significant association with fasting blood glucose and insulin in PCOS women (P < .05).
Conclusion
There are significant differences in plasma adiponectin concentrations between obese and non-obese women with polycystic ovary syndrome and normal controls.
期刊介绍:
Perinatología y Reproducción Humana is the official journal of the Instituto Nacional de Perinatología, Mexico. It is aimed at physicians of the area of perinatal and reproductive health (obstetrics and gynecology, maternal and fetal medicine, pediatricians, neonatologists, endocrinologists, infectious disease specialists, and neurologists) and also at health sciences professionals involved in the study of reproduction perinatal and reproductive health (chemists, biologists and neuro-physiologists). It is an electronic biannual journal, that publishes peer-reviewed original articles, in-deep reviews, letters to the editor and special sections related to basic, epidemiological, surgical, and clinical aspects in the area of perinatal and reproductive health, in English or Spanish languages and open access.