抗过敏原单克隆抗体用于治疗过敏

Niccolo Pengo PhD, Natascha Wuillemin PhD, Dimitri Bieli PhD, Pascal Gasser PhD
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引用次数: 0

摘要

背景为了应对日益严重的过敏流行病,迫切需要新的治疗方法。一个有前景的途径是开发抗过敏原抗体疗法。这种被动免疫方法与传统的过敏原免疫疗法不同,它不让患者接触过敏原,还可能治疗对过敏原免疫治疗反应较低甚至无反应的患者,并提供即时保护。方法回顾了抗过敏原抗体的历史和最新发表的文献,介绍了抗过敏源抗体的研究现状和最新进展。还讨论了在过敏原免疫治疗过程中发生的免疫变化的背景下的抗过敏原抗体治疗。结果尽管抗过敏原抗体的保护作用在几十年前就得到了认可,但抗体发现技术的进步推动了这一领域的发展,现在不同的抗过敏原-抗体疗法正在接近临床应用。这些进展也拓宽了我们对不同过敏性疾病中的过敏原和致敏表位的理解,以及免疫球蛋白在形成免疫系统中所起的作用。结论抗过敏原抗体疗法的发展为过敏的治疗提供了巨大的潜力。令人感兴趣的是,被动免疫方法的疗效可能会超越过敏原中和,因为在存在过敏原的情况下,它们可能有助于长期的疾病改变。
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Anti-allergen monoclonal antibodies for the treatment of allergies

Background

To tackle the growing allergy epidemic, novel therapeutic approaches are urgently needed. One promising avenue is the development of anti-allergen antibody therapies. This passive immunization approach stands out from traditional allergen immunotherapy by not exposing patients to the allergen but also by potentially treating patients who are less responsive or even unresponsive to allergen immunotherapies and providing immediate protection.

Methods

After a review of historical and recently published literature on the topic of anti-allergen antibodies, the status quo and recent advancements are presented. Anti-allergen antibody therapies in the context of immunological changes that occur during allergen immunotherapy are also discussed.

Results

While the protective role of anti-allergen antibodies was recognized decades ago, the advancement of antibody discovery technologies has fueled the field, and now different anti-allergen antibody therapies are approaching clinical use. These developments have also broadened our understanding of the allergens and allergenic epitopes responsible in different allergic diseases, and also the role played by immunoglobulins in shaping the immune system.

Conclusion

The development of anti-allergen antibody therapies offers great potential for the treatment of allergies. Of interest, the efficacy of passive immunization approaches will likely extend beyond allergen neutralization as in the presence of the allergen they might contribute to long-lasting disease modification.

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来源期刊
Allergo Journal International
Allergo Journal International Medicine-Immunology and Allergy
CiteScore
4.60
自引率
0.00%
发文量
31
期刊介绍: Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.
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