Synthesis of Silver Nanowires with Different Morphologies for Lung Cancer Treatment

In this publication, three silver nanowires (Ag NWs) with different morphologies were prepared via the polyol process synthesis method by changing the amount and kinds of inorganic agents in the synthesis procedure. The as-synthesized Ag NWs showed high yield and purity. The samples were fully characterized by scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD). The SEM results revealed that Ag NWs 1–3 have diameters of 95, 70, and 55–65 nm, respectively, and lengths of 20–30, 30–40, and 40–50 μm, respectively. The PXRD experiments showed that the as-synthesized samples display four typical diffraction peaks at 38.2°, 44.5°, 64.5°, and 77.4°, which are consistent with the face-centered cubic lattice for Ag. The inhibitory activities of the Ag NWs on the viability of lung cancer cells was measured with cell counting kit-8 assay. The activation activity of the vascular endothelial growth factor signaling pathway in the cancer cells was measured with real-time polymerase chain reaction.