纳米药物与间充质干细胞在老年烧伤患者中的应用

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2022.08.001
Wei Xiong , Rui Zhang , Heng Zhou , Ye Liu , Ming Liang , Keshen Li , Xingxiang Duan , David Pengcheng Chen , Yu Luo , Jia Xu , Yilong Ai , Yan He , Qingsong Ye
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引用次数: 3

摘要

烧伤不仅会破坏皮肤屏障,还会引起一系列炎症反应和氧化应激状态。其中,老年患者由于衰老因素导致皮肤萎缩、变薄等退行性变化,容易发生严重烧伤。烧伤后,机体会不断释放炎症因子,导致全身炎症反应综合征(systemic inflammatory response syndrome, SIRS)和氧化应激,这与老年烧伤患者治疗效果差、预后差有关。传统的治疗方法似乎难以有效控制老年烧伤患者的病情发展。考虑到老年人口的快速增长,了解老年烧伤患者的病理过程和机制,制定更合适的治疗策略是当务之急。近年来,由于纳米技术的巨大进步,各种纳米材料被开发用于伤口愈合和炎症调节。其良好的生物相容性、刺激细胞增殖和抗菌性能使其临床治疗策略更加优化。同时,间充质干细胞(mesenchymal stem cells, MSCs)也被应用于烧伤领域,不仅在控制炎症水平和调节全身免疫平衡方面有效,而且还能促进伤口愈合和血管形成。本文就烧伤的分类、老年烧伤患者的病理过程以及纳米技术和间充质干细胞在烧伤中的研究进展进行综述。最后,我们总结了纳米技术和间充质干细胞等新兴策略在老年烧伤患者治疗中的优势和挑战,以期促进临床转型。
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Application of nanomedicine and mesenchymal stem cells in burn injuries for the elderly patients

Burns not only damage the skin barrier, but also cause a series of inflammatory reactions and oxidative stress states. Among them, elderly patients are prone to suffer severe burns due to degenerative changes of their skin caused by aging factors, such as atrophy and thinning, etc. After burns, the body will continuously release inflammatory factors, resulting in systemic inflammatory response syndrome (SIRS) and oxidative stress, which are related to the poor treatment effect and the poor prognosis of elderly burn patients. It seems to be difficult for conventional treatments to control the disease development of elderly burn patients effectively. Considering the rapidly increasing elderly population, it is priority to understand the pathological process and the mechanisms to formulate more appropriate treatment strategies for elderly burn patients. In recent years, owing to considerable advances in nanotechnology, a variety of nanomaterials have been developed for wound healing and inflammation regulation. Its good biocompatibility, cell proliferation stimulation and antibacterial properties make the clinical treatment strategy more optimized. Concurrently, mesenchymal stem cells (MSCs) have also been used in the burns field and have been proven effective in not only controlling the level of inflammation and regulating the systemic immune balance, but also promoting wound healing and vascularization. Here, this review covers burns classification, the pathological process of elderly burn patients, and the research progress of nanotechnology and MSCs in burns. Eventually, we summarize the advantages and challenges of emerging strategies such as nanotechnology and MSCs in the treatment of elderly burn patients, expecting to promote the clinical transformation.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
期刊最新文献
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