血清同型半胱氨酸水平在溃疡性结肠炎中升高,可作为诊断性生物标志物

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2022-01-01 DOI:10.1515/pteridines-2022-0046
Xiaoping Zhang, Shanshan Wang, Hongmin Wang, Jun-min Wu, Q. Tan
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引用次数: 0

摘要

摘要目的探讨血清同型半胱氨酸(Hcy)水平与溃疡性结肠炎(UC)的相关性,并通过汇集公开发表的数据来评估其诊断性能。方法采用“同型半胱氨酸”、“Hcy”、“UC”、“炎症性肠病”等文本词,系统筛选Pubmed、Medline、EMBASE、中国万方和CNKI数据库中发表的与Hcy和UC血清水平相关的病例对照或队列研究。还计算了血清Hcy对UC的诊断敏感性、特异性和受试者工作特性曲线下面积(AUC)。结果通过电子检索相关数据库,确定了18项相关病例对照研究。合并结果表明,UC和健康对照组的血清Hcy水平存在统计学差异,SMD=0.95(95%CI:0.87–1.04)。Hcy水平分别为14.30±3.08(范围:10.10–21.73)和10.09±1.57(范围:6.80–12.47) μmol/L,分别用于UC和健康对照。使用血清Hcy作为UC识别的生物标志物,诊断灵敏度、特异性和AUC分别为94.44%(95%CI:72.71–99.86%)、72.22%(46.52–90.31%)和0.88(95%CI:0.77–0.99,P<0.05)。在目前的工作中发现了重大的出版偏见。结论UC患者血清Hcy升高,可作为UC诊断的血清学标志物。然而,由于显著的发表偏倚,诊断性能应通过精心设计的前瞻性诊断研究进一步验证。
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Serum homocysteine level was elevated in ulcerative colitis and can be applied as diagnostic biomarker
Abstract Objective To investigate the correlation between serum level of homocysteine (Hcy) and ulcerative colitis (UC) and evaluate its diagnostic performance by pooling the open published data. Methods The case–control or cohort studies relevant to serum level of Hcy and UC, published in Pubmed, Medline, EMBASE, China Wanfang and CNKI databases, were systematically screened by using the text word of “homocysteine,” “hcy,” “UC,” “inflammatory bowel disease.” The standard mean difference (SMD) was pooled through random effect model. The diagnostic sensitivity, specificity and area under the receiver operating characteristic (AUC) curve of serum Hcy for UC were also calculated. Results Eighteen relevant case–control studies were identified by electronic searching the related databases. The pooled results indicated that the serum levels of Hcy were statical different between UC and healthy controls with SMD = 0.95 (95% CI: 0.87–1.04). The serum levels of Hcy were 14.30 ± 3.08 (range: 10.10–21.73) and 10.09 ± 1.57 (range: 6.80–12.47) μmol/L for UC and healthy controls, respectively, of the included 18 studies. Using serum Hcy as biomarker for UC identification, the diagnostic sensitivity, specificity and AUC were 94.44% (95% CI: 72.71–99.86%), 72.22% (46.52–90.31%) and 0.88 (95% CI: 0.77–0.99, P < 0.05), respectively. Significant publication bias was identified in the present work. Conclusion Based on the present publications, serum Hcy was elevated in UC cases and can be applied as serological marker for UC diagnosis. However, due to significant publication bias, the diagnostic performance should be further validated by well-designed prospective diagnostic studies.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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