基于反向风险率的相关复合几何脆弱性模型

David D. Hanagal
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引用次数: 0

摘要

脆弱性模型用于生存分析,以解释未观察到的个体疾病和死亡风险的异质性。为了分析相关生存时间的双变量数据(例如配对实验、双胞胎或家庭数据),提出了共享虚弱模型。尽管存在局限性,但仍使用共享脆弱性模型。为了克服它们的缺点,可以使用相关的脆弱性模型。在本文中,我们引入了基于反向风险率的相关复合几何脆弱性模型,该模型具有三种不同的基线分布,即广义log-logistic类型I、广义log-logistic类型II和修正的逆威布尔。我们介绍了使用马尔可夫链蒙特卡罗(MCMC)技术来估计这些模型中涉及的参数的贝叶斯估计过程。我们进行了一项模拟研究,将参数的真实值与估计值进行比较。我们还将所提出的模型应用于澳大利亚双胞胎数据集,并提出了一个更好的模型。
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Correlated compound geometric frailty models based on reversed hazard rate
Frailty models are used in the survival analysis to account for the unobserved heterogeneity in individual risks to disease and death. To analyze the bivariate data on related survival times (e.g. matched pairs experiments, twin or family data), the shared frailty models were suggested. Shared frailty models are used despite their limitations. To overcome their disadvantages correlated frailty models may be used. In this paper, we introduce the correlated compound geometric frailty models based on reversed hazard rate with three different baseline distributions namely, the generalized log-logistic type I, the generalized log-logistic type II and the modified inverse Weibull. We introduce the Bayesian estimation procedure using Markov Chain Monte Carlo (MCMC) technique to estimate the parameters involved in these models. We present a simulation study to compare the true values of the parameters with the estimated values. We also apply the proposed models to the Australian twin data set and a better model is suggested.
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来源期刊
Model Assisted Statistics and Applications
Model Assisted Statistics and Applications Mathematics-Applied Mathematics
CiteScore
1.00
自引率
0.00%
发文量
26
期刊介绍: Model Assisted Statistics and Applications is a peer reviewed international journal. Model Assisted Statistics means an improvement of inference and analysis by use of correlated information, or an underlying theoretical or design model. This might be the design, adjustment, estimation, or analytical phase of statistical project. This information may be survey generated or coming from an independent source. Original papers in the field of sampling theory, econometrics, time-series, design of experiments, and multivariate analysis will be preferred. Papers of both applied and theoretical topics are acceptable.
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