Targeting liver sinusoidal endothelial cell activation during angiogenesis using miRNA: a new therapeutic approach against liver metastasis

Colorectal cancer is the third most frequently occurring cancer and a common cause of cancer-related death worldwide (1). The most common metastatic target organ of colorectal cancer is the liver (2). The first interaction between colon cancer cell and liver occurs in the liver sinusoid. The narrow fenestrated capillaries of the hepatic tissue (3). The tumor cell is trapped in this space and start the interaction between metastatic cell and host organ.