含N-芳基琥珀酰亚胺和二苯并巴龙烯部分的新型聚偶氮化合物的合成、表征及其抗菌活性

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1515/hc-2022-0157

Njoya Abdou Salamou, Tamokou Jean-de-Dieu, Sopbué Fondjo Emmanuel, Matsuete Takongmo Germaine, Bitchagno Mbahbou T. Gabin, Peter F. W. Simon, A. Tsopmo, Kuiate Jules-Roger

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摘要

摘要本工作描述了一种新的聚偶氮化合物的合成、表征和抗菌活性的评估，该化合物是由先前报道的N-芳基琥珀酰亚胺前体5与苯胺的重氮离子偶联得到的。使用其物理、元素以及1D和2D光谱数据对该偶氮化合物进行了表征。新型偶氮化合物7（最小抑制浓度[MIC]=16-32 μg/mL）显示出比其前体5更高的抗菌活性（MIC=32–64 μg/mL），尽管与参考药物环丙沙星相比（MIC=0.5-4 μg/mL）。图形摘要

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Synthesis, characterization, and antibacterial activity of a new poly azo compound containing N-arylsuccinimid and dibenzobarrelene moieties

Abstract The present work describes the synthesis, characterization, and evaluation of the antibacterial activity of a new poly azo compound resulting from the coupling of a previously reported N-arylsuccinimid precursor 5 with the diazonium ion of aniline. This azo compound was characterized using its physical, elemental, and 1D and 2D spectroscopic data. The novel azo compound 7 (minimum inhibitory concentration [MIC] = 16–32 μg/mL) showed higher antibacterial activity than its precursor 5 (MIC = 32–64 μg/mL), although it was low compared to the reference drug ciprofloxacin (MIC = 0.5–4 μg/mL). Graphical abstract

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.