Diego A Flores-Napa, L. Correa-López, J. R. Torres-Malca, Willer Chanduví Puicón, V. Vera-Ponce, J. A. De La Cruz-Vargas
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引用次数: 0
摘要
结直肠癌(CRC)是世界上第三大被诊断出的癌症,占所有癌症诊断的11%。人们已经看到肥胖与这种疾病密切相关。材料与方法:本研究为非配对病例对照研究。采用体重指数(BMI)、新体重指数(NBMI)和三体指数(TPI)来测量肥胖。采用Logistic回归获得按年龄、性别、可信区间(95%CI)调整的优势比(aOR)。结果:样本为246例。根据BMI,肥胖患病率为12.20%。多变量分析发现,根据BMI,结直肠癌与肥胖之间存在显著的统计学相关性(aOR: 3.23;95% CI 1.26-8.30);NBMI指数为3 (aOR: 4.02;95% CI 1.95-8.30),与0.05相比;TPI为3 (aOR: 4.55;95%可信区间为2.21-9.35)。结论:肥胖是结直肠癌的危险因素。未来的研究可能会考虑用不同的方法来测量肥胖,以确定结直肠癌的高危人群。
Obesity indices as risk factor for colorectal cancer in patients at a national police hospital in Peru
Introduction: Colorectal cancer (CRC) represents the third most diagnosed form of cancer around the world, accounting for 11% of all cancer diagnoses. It has been seen that obesity is closely linked to this disease.
Materials and methods: This study is a non-paired case-control study. To measure obesity, the body mass index (BMI), new body mass index (NBMI), and the triponderal index (TPI) were used. Logistic regression was used to obtain the adjusted odds ratio (aOR) by age and sex, confidence interval (95%CI).
Results: The sample was 246 patients. The prevalence of obesity according to BMI was 12.20%. The multivariable analysis found statistically significant association between CRC and obesity according to BMI (aOR: 3.23; 95% CI 1.26-8.30) compared to normal weight; NBMI tertile 3 (aOR: 4.02; 95% CI 1.95-8.30), compared to tertile 1; and TPI tertile 3 (aOR: 4.55; 95% CI 2.21-9.35) versus tertile 1.
Conclusions: Obesity, is a risk factor for CRC. Future studies might consider useful different ways to measure obesity to define population strata with a higher-risk of CRC.