动脉粥样硬化和缺血性卒中的交叉对话:中性粒细胞的戏剧性作用

IF 0.4 Q4 NEUROSCIENCES Archives of Neuroscience Pub Date : 2021-07-06 DOI:10.5812/ANS.104433
A. Esmaeilzadeh, Maryam Zarerafie, Azita Mohammadzadeh
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引用次数: 0

摘要

背景:目前的研究表明,不适当的生活方式加重了动脉粥样硬化(AS)的发病率。动脉粥样硬化是缺血性中风(is)等重要血管相关疾病的病因。了解AS的病理生理学可以帮助降低AS介导的疾病如缺血性中风的发生率。证据获取:在这篇叙述性综述文章中,我们使用了PubMed、Google Scholar、Scopus、Springer和Science Direct的五个大型数据库。我们从2010年1月到2020年12月进行了搜索,根据关键词和收录标准,共收录了77篇文章。结果:根据先前关于动脉粥样硬化和缺血性卒中病理生理学的文章,局部和全身炎症是这两种疾病的一个重要因素。事实上,基本的炎症途径涉及动脉粥样硬化,缺血性卒中与toll样受体4/髓系分化原代反应88/核因子κB(TLR4/Myd88/NF-κB)级联有关。这些复杂机制的功能爪是促炎介质,如白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)和白细胞介蛋白-18(IL-18)引起炎症。此外,被称为炎症小体(多蛋白组分)的基本结构以及免疫和非免疫细胞(即中性粒细胞、单核细胞、血小板和巨噬细胞)的多样性有利于诱导炎症微环境。结论:中性粒细胞可能是IS和AS炎症机制中最有效的细胞。研究表明,中性粒细胞通过募集自身的囊泡和颗粒可以放大炎症条件,是AS和IS串扰的关键细胞。因此,利用方法控制中性粒细胞介导的机制可能是预防AS和IS的有效方法。
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Cross-Talk of Atherosclerosis and Ischemic Stroke: Dramatic Role of Neutrophils
Context: Current investigations illustrate the increasing prevalence of atherosclerosis (AS) through the aggravating role of inappropriate lifestyle patterns. Atherosclerosis is the cause of important vascular-related diseases such as ischemic stroke (IS). Understanding AS pathophysiology can help reduce the incidence of AS-mediated diseases like ischemic stroke. Evidence Acquisition: For this narrative review article, we used the five mega databases of PubMed, Google Scholar, Scopus, Springer, and Science Direct. We searched from 2010 Jan to 2020 Dec and based on keywords and inclusion criteria, 77 articles were enrolled. Results: Based on prior articles on atherosclerosis and ischemic stroke pathophysiology, local and systemic inflammation is a vigorous factor in both diseasesIndeed, the fundamental inflammatory pathway involved atherosclerosis, and ischemic stroke is associated with the toll-like receptor 4/myeloid differentiation primary response 88/nuclear factor-kappa B (TLR4/ Myd88/ NF-κB) cascade. The functional paw of these intricate mechanisms are pro-inflammatory mediators, such as interleukin-1 beta (IL-1β), tumor necrosis factor (TNF-α), and interleukin-18 (IL-18) incite inflammation. Besides, the essential structures termed inflammasomes (multi proteins components), and multiplicity of immune and non-immune cells (i.e., neutrophils, monocytes, platelets, and macrophages) are beneficial in the induction of inflammatory microenvironment. Conclusions: Neutrophils could be the most effective cells in the inflammation-based mechanism in IS and AS. It is clarified that neutrophils with the recruitment of own vesicles and granules can afford to amplify inflammatory conditions and be a key cell in AS and IS cross-talk. Therefore, utilizing methods to control neutrophils-mediated mechanisms could be an effective method for the prevention of AS and IS.
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Archives of Neuroscience
Archives of Neuroscience NEUROSCIENCES-
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期刊介绍: Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.
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