硫蝎毒TbⅡ-Ⅰ脑内注射对多巴胺能代谢的影响

IF 3.6 Q2 TOXICOLOGY Toxicon: X Pub Date : 2022-09-01 DOI:10.1016/j.toxcx.2022.100126

Beraldo-Neto Emidio , Lebrun Ivo , Nencioni Ana Leonor Abrahao

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引用次数: 1

摘要

从巴海提鱼毒液中分离出的结核菌i - i注射到大鼠的海马体中会引起癫痫放电。研究了神经递质在这一活动中的作用。我们的研究结果表明，Tb i - i - i增加了多巴胺代谢物的浓度，但不改变其他神经递质。因此，多巴胺能系统似乎对抽搐过程负有部分责任。对特定神经递质的特定作用可以使这种毒素成为更好地了解系统功能的有用工具。

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Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom

Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the concentrations of dopamine metabolite but does not alter other neurotransmitters. Thus, dopaminergic system seems to be partially responsible for the convulsive process. Specific action on particular neurotransmitter can make this toxin a useful tool to better understand the functioning of the system.

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