{"title":"目的探讨脊髓麻醉下剖宫产时预防性输注25、50 μg/Min苯肾上腺素对产妇低血压、不良反应及胎儿酸碱平衡的影响","authors":"R. Akshay, J. Bajaj","doi":"10.4103/JOACC.JOACC_67_22","DOIUrl":null,"url":null,"abstract":"Objectives: To study maternal hypotension, side effects, and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/min phenylephrine. Methods: This prospective randomized study was carried out at a tertiary care hospital on 100 pregnant women who underwent caesarean section under subarachnoid block. The participants were randomized into: Group P1 (n = 50): who received phenylephrine 25 μg/min infusion prophylactically and Group P2 (n = 50) received phenylephrine 50 μg/min infusion prophylactically. The two groups were compared for heart rate, blood pressure, side effects, and fetal arterial and venous blood gas analysis. P value < 0.05 was considered statistically significant. Results: In group P1, 3 (6%) patients had episode of hypotension and in group P2, 1 (2%) patient had episode of hypotension. There was no incidence of hypertension in group P1 but in group P2, 5 (10%) patients had hypertension (p < 0.05). There was no episode of bradycardia or oxygen desaturation in any group. Side effects were Grade 1 in three patients each in both the groups, and Grade 2 in one patient of Group P1 and four patients in Group P2 (p = 0.842). Fetal acid-base balance was comparable in the two groups (p > 0.05). Conclusion: It can be concluded that 50 μg/min phenylephrine was able to better prevent maternal hypotension with comparable side-effects profile and fetal acid base balance.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"To study maternal hypotension, side-effects and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/Min phenylephrine\",\"authors\":\"R. Akshay, J. Bajaj\",\"doi\":\"10.4103/JOACC.JOACC_67_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: To study maternal hypotension, side effects, and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/min phenylephrine. Methods: This prospective randomized study was carried out at a tertiary care hospital on 100 pregnant women who underwent caesarean section under subarachnoid block. The participants were randomized into: Group P1 (n = 50): who received phenylephrine 25 μg/min infusion prophylactically and Group P2 (n = 50) received phenylephrine 50 μg/min infusion prophylactically. The two groups were compared for heart rate, blood pressure, side effects, and fetal arterial and venous blood gas analysis. P value < 0.05 was considered statistically significant. Results: In group P1, 3 (6%) patients had episode of hypotension and in group P2, 1 (2%) patient had episode of hypotension. There was no incidence of hypertension in group P1 but in group P2, 5 (10%) patients had hypertension (p < 0.05). There was no episode of bradycardia or oxygen desaturation in any group. Side effects were Grade 1 in three patients each in both the groups, and Grade 2 in one patient of Group P1 and four patients in Group P2 (p = 0.842). Fetal acid-base balance was comparable in the two groups (p > 0.05). Conclusion: It can be concluded that 50 μg/min phenylephrine was able to better prevent maternal hypotension with comparable side-effects profile and fetal acid base balance.\",\"PeriodicalId\":16611,\"journal\":{\"name\":\"Journal of Obstetric Anaesthesia and Critical Care\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetric Anaesthesia and Critical Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/JOACC.JOACC_67_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetric Anaesthesia and Critical Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/JOACC.JOACC_67_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
To study maternal hypotension, side-effects and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/Min phenylephrine
Objectives: To study maternal hypotension, side effects, and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/min phenylephrine. Methods: This prospective randomized study was carried out at a tertiary care hospital on 100 pregnant women who underwent caesarean section under subarachnoid block. The participants were randomized into: Group P1 (n = 50): who received phenylephrine 25 μg/min infusion prophylactically and Group P2 (n = 50) received phenylephrine 50 μg/min infusion prophylactically. The two groups were compared for heart rate, blood pressure, side effects, and fetal arterial and venous blood gas analysis. P value < 0.05 was considered statistically significant. Results: In group P1, 3 (6%) patients had episode of hypotension and in group P2, 1 (2%) patient had episode of hypotension. There was no incidence of hypertension in group P1 but in group P2, 5 (10%) patients had hypertension (p < 0.05). There was no episode of bradycardia or oxygen desaturation in any group. Side effects were Grade 1 in three patients each in both the groups, and Grade 2 in one patient of Group P1 and four patients in Group P2 (p = 0.842). Fetal acid-base balance was comparable in the two groups (p > 0.05). Conclusion: It can be concluded that 50 μg/min phenylephrine was able to better prevent maternal hypotension with comparable side-effects profile and fetal acid base balance.