目的探讨脊髓麻醉下剖宫产时预防性输注25、50 μg/Min苯肾上腺素对产妇低血压、不良反应及胎儿酸碱平衡的影响

R. Akshay, J. Bajaj
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引用次数: 0

摘要

目的:观察腰麻下剖宫产时预防性输注25、50 μg/min苯肾上腺素对产妇低血压、不良反应及胎儿酸碱平衡的影响。方法:本前瞻性随机研究在某三级医院对100例经蛛网膜下腔阻滞剖宫产的孕妇进行。随机分为:P1组(n = 50)预防性滴注苯肾上腺素25 μg/min, P2组(n = 50)预防性滴注苯肾上腺素50 μg/min。比较两组患者心率、血压、副作用及胎儿动、静脉血气分析。P值< 0.05为差异有统计学意义。结果:P1组3例(6%)患者出现低血压发作,P2组1例(2%)患者出现低血压发作。P1组无高血压,P2组有5例(10%)高血压(p < 0.05)。两组均未发生心动过缓或氧饱和度过低。两组毒副反应均为1级3例,P1组毒副反应为1例,P2组毒副反应为4例(p = 0.842)。两组胎儿酸碱平衡具有可比性(p < 0.05)。结论:50 μg/min的苯肾上腺素能较好地预防产妇低血压,且副作用和胎儿酸碱平衡相当。
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To study maternal hypotension, side-effects and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/Min phenylephrine
Objectives: To study maternal hypotension, side effects, and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/min phenylephrine. Methods: This prospective randomized study was carried out at a tertiary care hospital on 100 pregnant women who underwent caesarean section under subarachnoid block. The participants were randomized into: Group P1 (n = 50): who received phenylephrine 25 μg/min infusion prophylactically and Group P2 (n = 50) received phenylephrine 50 μg/min infusion prophylactically. The two groups were compared for heart rate, blood pressure, side effects, and fetal arterial and venous blood gas analysis. P value < 0.05 was considered statistically significant. Results: In group P1, 3 (6%) patients had episode of hypotension and in group P2, 1 (2%) patient had episode of hypotension. There was no incidence of hypertension in group P1 but in group P2, 5 (10%) patients had hypertension (p < 0.05). There was no episode of bradycardia or oxygen desaturation in any group. Side effects were Grade 1 in three patients each in both the groups, and Grade 2 in one patient of Group P1 and four patients in Group P2 (p = 0.842). Fetal acid-base balance was comparable in the two groups (p > 0.05). Conclusion: It can be concluded that 50 μg/min phenylephrine was able to better prevent maternal hypotension with comparable side-effects profile and fetal acid base balance.
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