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Fahr and beyond: Anesthesia for obstetric emergency in a patient with fahr's syndrome Fahr及以后:Fahr综合征患者产科急诊的麻醉
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_34_23
Swati Taneja, Bhavya Krishna
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引用次数: 0
Amniotic fluid embolism: A narrative review 羊水栓塞:叙述性综述
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_12_23
Frederick Baxter
Amniotic fluid embolism (AFE) is a rare but deadly complication of pregnancy. First described in 1926, it remains a diagnosis of exclusion, without clear etiology or a specific test to confirm the diagnosis. Mortality remains high and neurological injury is common among survivors, although reported case fatality rates are decreasing over time. Hemodynamic instability appears to be caused by severe pulmonary vasospasm and subsequent right heart failure, followed by severe left ventricular failure. Presentation is often sudden with loss of consciousness and circulatory arrest, requiring immediate cardiopulmonary resuscitation, vasopressor and inotropic support, and endotracheal intubation. Disseminated intravascular coagulation commonly follows with severe coagulopathy and postpartum hemorrhage and may in some cases be the primary presenting feature. Management remains largely supportive, with the use of extracorporeal membrane oxygenation and inhaled pulmonary vasodilators assuming an increased role, in addition to advanced life support methods. Blood products and coagulation factor replacement are frequently required, sometimes in the form of a massive transfusion. This narrative review summarizes the past and current literature, emphasizing rapid identification of AFE and therapeutic options for its immediate management.
羊水栓塞(AFE)是一种罕见但致命的妊娠并发症。羊水栓塞于 1926 年首次被描述,但至今仍是一种排除性诊断,既没有明确的病因,也没有特定的检测方法来确诊。尽管随着时间的推移,报告的病死率正在下降,但死亡率仍然很高,幸存者中神经损伤也很常见。血流动力学不稳定似乎是由严重的肺血管痉挛和随后的右心衰竭引起的,随后是严重的左心室衰竭。患者通常突然出现意识丧失和循环停止,需要立即进行心肺复苏、血管加压和肌力支持以及气管插管。弥散性血管内凝血通常伴有严重的凝血功能障碍和产后出血,在某些病例中可能是主要的发病特征。治疗仍以支持性治疗为主,除高级生命支持方法外,体外膜肺氧合和吸入性肺血管扩张剂的使用也越来越多。患者经常需要补充血制品和凝血因子,有时需要大量输血。这篇叙述性综述总结了过去和当前的文献,强调了快速识别 AFE 和立即处理 AFE 的治疗方案。
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引用次数: 0
To compare the efficacy of two different bolus doses of phenylephrine in combination with oxytocin in preventing oxytocin-induced hypotension during cesarean section under spinal anesthesia: A randomized comparative study 比较两种不同剂量的苯肾上腺素联合催产素预防腰麻剖宫产术中催产素引起的低血压的疗效:一项随机比较研究
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_72_22
S. Kumari, Ratindra Barman, Pranab Kalita, Peter Engti
Background: A randomized comparative study was conducted to assess the effectiveness of two different bolus doses of phenylephrine to obtund the hypotensive effects of bolus oxytocin injection in patients undergoing cesarean section under spinal anesthesia. Methods: The study involved 180 parturients belonging to the ASAI and II, undergoing CS under SA were randomized into three groups, group A: oxytocin 3U and phenylephrine 50 μg; group B: oxytocin 3U and phenylephrine 75 μg; group C: oxytocin 3U and normal saline, administered intravenously over 5 min after delivery of anterior shoulder. The incidence of hypotension being the primary objective and hemodynamic changes, the incidence of nausea and vomiting, and other complications, such as total rescue vasopressor requirement, adequacy of uterine contraction, and the number of patients requiring additional uterotonics, were our secondary objectives. Results: The incidence of hypotension was highest in group C (83.3%) followed by group A (80%) and lowest in group B (11.6%). The total rescue doses of PE after T0 between the three groups showed that group A required (61.32 ± 41.19) μg, group B required (10.19 ± 29.75) μg, and group C required (113.21 ± 47.18) μg of PE. The uterine contraction was comparable between the groups. Incidence of nausea and vomiting and other complications were comparable between the groups. Conclusion: Co-administration of PE 75 μg with OT 3 IU after delivery reduces the incidence of OT-induced hypotension and rescue vasopressor requirement compared to co-administration of 50 μg PE during CS under spinal anesthesia.
背景:进行了一项随机比较研究,以评估两种不同剂量的苯肾上腺素对腰麻下剖宫产患者单次注射催产素的降压效果的有效性。方法:将180例ASAI和II期SA下CS产妇随机分为三组:A组:催产素3U和苯肾上腺素50μg;B组:催产素3U和苯肾上腺素75μg;C组:催产素3U和生理盐水,在前肩分娩后5min以上静脉注射。低血压的发生率是主要目标,血液动力学变化、恶心和呕吐的发生率以及其他并发症,如完全抢救性血管升压药的需求、子宫收缩的充分性以及需要额外子宫补剂的患者数量,是我们的次要目标。结果:C组低血压发生率最高(83.3%),其次为A组(80%),B组最低(11.6%)。三组T0后PE总抢救剂量分别为:A组需要(61.32±41.19)μg、B组需要(10.19±29.75)μg和C组需要(113.21±47.18)μg PE。恶心呕吐和其他并发症的发生率在两组之间具有可比性。结论:与腰麻CS期间50μg PE联合给药相比,产后75μg PE与OT3IU联合给药可降低OT引起的低血压的发生率和抢救性血管升压药需求。
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引用次数: 0
Carbetocin: Are we ready for a paradigm shift? 卡贝素:我们准备好进行范式转变了吗?
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_55_23
Anjeleena Gupta
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引用次数: 0
To study maternal hypotension, side-effects and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/Min phenylephrine 目的探讨脊髓麻醉下剖宫产时预防性输注25、50 μg/Min苯肾上腺素对产妇低血压、不良反应及胎儿酸碱平衡的影响
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_67_22
R. Akshay, J. Bajaj
Objectives: To study maternal hypotension, side effects, and fetal acid-base balance during cesarean delivery under spinal anesthesia using prophylactic infusion doses of 25 and 50 μg/min phenylephrine. Methods: This prospective randomized study was carried out at a tertiary care hospital on 100 pregnant women who underwent caesarean section under subarachnoid block. The participants were randomized into: Group P1 (n = 50): who received phenylephrine 25 μg/min infusion prophylactically and Group P2 (n = 50) received phenylephrine 50 μg/min infusion prophylactically. The two groups were compared for heart rate, blood pressure, side effects, and fetal arterial and venous blood gas analysis. P value < 0.05 was considered statistically significant. Results: In group P1, 3 (6%) patients had episode of hypotension and in group P2, 1 (2%) patient had episode of hypotension. There was no incidence of hypertension in group P1 but in group P2, 5 (10%) patients had hypertension (p < 0.05). There was no episode of bradycardia or oxygen desaturation in any group. Side effects were Grade 1 in three patients each in both the groups, and Grade 2 in one patient of Group P1 and four patients in Group P2 (p = 0.842). Fetal acid-base balance was comparable in the two groups (p > 0.05). Conclusion: It can be concluded that 50 μg/min phenylephrine was able to better prevent maternal hypotension with comparable side-effects profile and fetal acid base balance.
目的:观察腰麻下剖宫产时预防性输注25、50 μg/min苯肾上腺素对产妇低血压、不良反应及胎儿酸碱平衡的影响。方法:本前瞻性随机研究在某三级医院对100例经蛛网膜下腔阻滞剖宫产的孕妇进行。随机分为:P1组(n = 50)预防性滴注苯肾上腺素25 μg/min, P2组(n = 50)预防性滴注苯肾上腺素50 μg/min。比较两组患者心率、血压、副作用及胎儿动、静脉血气分析。P值< 0.05为差异有统计学意义。结果:P1组3例(6%)患者出现低血压发作,P2组1例(2%)患者出现低血压发作。P1组无高血压,P2组有5例(10%)高血压(p < 0.05)。两组均未发生心动过缓或氧饱和度过低。两组毒副反应均为1级3例,P1组毒副反应为1例,P2组毒副反应为4例(p = 0.842)。两组胎儿酸碱平衡具有可比性(p < 0.05)。结论:50 μg/min的苯肾上腺素能较好地预防产妇低血压,且副作用和胎儿酸碱平衡相当。
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引用次数: 0
Airtraq as an alternative device for airway management for emergency cesarean section in a parturient with kyphoscoliosis and short stature – A case report Airtraq作为紧急剖宫产术中脊柱后凸和身材矮小患者气道管理的替代设备- 1例报告
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_65_22
K. Narayanan, Geeta Bhandari, A. Nautiyal, Abha Tiwari
Kyphoscoliosis is a spine abnormality identified by anterior flexion (kyphosis) and lateral curvature (scoliosis) and its causes can be multifactorial. A 24-year-old primigravida with short stature and severe thoracolumbar kyphoscoliosis was scheduled for emergency cesarean section due to non-progression of labor with fetal distress. After failed spinal and unsuccessful conventional laryngoscopy, the patient was intubated using an optical Airtraq (Prodol Meditec S.A., Vizcaya, Spain) laryngoscope and operated. The main purpose of an anesthesiologist is to perform safe and skilled anesthetic management to minimize risk to mother and baby. Kyphoscoliosis exacerbates an already compromised cardiopulmonary status due to pregnancy. The severity of pulmonary impairment depends upon the degree of Cobb's angle. None of the anesthetic techniques is said to be perfect as each technique has its own merits and demerits. General anesthesia may be indicated because of maternal preference or maternal cardiopulmonary disease or technical difficulties related to the regional block. Airtraq can be an alternative option for airway management as it provides a direct view of the glottis in a neutral neck position.
后凸性脊柱侧凸是一种脊柱异常,表现为前屈(后凸)和侧弯(脊柱侧凸),其病因可能是多因素的。一个24岁的初产妇,身材矮小,严重胸腰椎后凸侧凸,由于分娩不进展,胎儿窘迫,被安排紧急剖宫产。在脊柱和常规喉镜检查失败后,患者使用光学Airtraq (Prodol Meditec s.a., vizcaa, Spain)喉镜插管并进行手术。麻醉师的主要目的是执行安全和熟练的麻醉管理,以尽量减少对母亲和婴儿的风险。后凸加剧了已经受损的心肺状态,由于怀孕。肺损伤的严重程度取决于柯布角的程度。没有一种麻醉技术被认为是完美的,因为每种技术都有自己的优点和缺点。由于产妇偏好或产妇心肺疾病或与区域阻滞相关的技术困难,可能需要全麻。Airtraq可以作为气道管理的另一种选择,因为它提供了在颈部中立位置的声门的直接视图。
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引用次数: 0
Anesthetic management of cesarean section in a patient with Léri-Weill dyschondrosteosis – A case report Léri Weill软骨发育不全症患者剖宫产的麻醉处理——一例报告
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_75_22
Muizz Hussain, Nikhil Nair, Matthew Foss, James Paul
When providing spinal anesthesia for patients with achondroplasia, a dose reduction is often recommended to prevent respiratory arrest and total spinal blocks as patients with achondroplasia present with spinal complications such as spinal cord stenosis, kyphoscoliosis, and lumbar lordosis. This case report describes why this dose reduction is unnecessary in patients with Léri–Weill dyschondrosteosis (LWD) dwarfism and how a regular spinal neuraxial approach is safe and efficacious. A 38-year-old pregnant woman with physical findings consistent with LWD and unremarkable past medical history presented for a repeat elective cesarean section. On examination, the patient was noted to have conserved spinal length and anatomy. In accordance with current recommendations, this patient received a 20% reduced spinal anesthetic dose for her cesarean section based on her height. The cesarean was uneventful. Additional dose reduction was found to be unnecessary due to normal spinal length and anatomy. This characteristic of LWD warrants a review of the clinical recommendations surrounding the anesthetic management of patients with LWD.
当为软骨发育不全患者提供脊柱麻醉时,通常建议减少剂量,以防止呼吸停止和完全脊柱阻滞,因为软骨发育不全病患者会出现脊髓狭窄、后凸和腰椎前凸等脊柱并发症。本病例报告描述了为什么在Léri–Weill软骨发育不良症(LWD)侏儒症患者中不需要减少剂量,以及常规脊髓-神经轴入路是如何安全有效的。一名38岁的孕妇,其身体检查结果与LWD一致,既往病史不明显,建议再次进行选择性剖宫产。在检查中,患者注意到脊柱长度和解剖结构是保守的。根据目前的建议,该患者在剖宫产时根据身高减少了20%的脊椎麻醉剂量。剖宫产手术平安无事。由于脊柱长度和解剖结构正常,额外的剂量减少被发现是不必要的。LWD的这一特点值得对LWD患者麻醉管理的临床建议进行审查。
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引用次数: 0
Comparative evaluation of two doses of phenylephrine infusion to prevent intra-operative nausea and vomiting during elective obstetric spinal anesthesia 两种剂量苯肾上腺素预防选择性产科脊髓麻醉术中恶心呕吐的比较评价
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_58_22
Vikram Bedi, Anchal Jhawer, Santosh Choudhary, Sandeep Savitaprakash Sharma, Yadav Pratibha, Debbarma Sanghamitra
Background and Aims: Hypotension is very common after obstetric spinal anesthesia. Maternal hypotension in turn leads to intra-operative nausea and/or vomiting (IONV). We planned this study to compare the effect of phenylephrine infusion of 25 μg/min and 50 μg/min for preventing IONV in patients undergoing elective lower segment cesarean section. Material and Methods: This prospective double-blind randomized placebo controlled trial was conducted on 195 parturients with singleton pregnancy undergoing elective cesarean section under subarachnoid block. Parturients were randomly allocated into three groups, groups C, P25, and P50, to receive normal saline at 15 ml/hour, 100 μg/ml phenylephrine as 15 ml/hour infusion (dose 25 μg/min), and 200 μg/ml phenylephrine as 15 ml/hour infusion (dose 50 μg/min), respectively. Groups were compared with regard to incidence of IONV, rescue mephentermin consumption, hemodynamic parameters, neonatal outcome, and adverse effects. Categorical data were presented as number and compared using Chi-square test. Continuous variables were presented as mean ± SD and compared using t-test or ANOVA. P < 0.05 was considered statistically significant. Results: Group PE50 experienced a significantly lesser number of episodes of IONV compared to group PE25 and group C (0.09 ± 0.29 versus 0.23 ± 0.42 and 0.55 ± 0.84, respectively; P < 0.05). Group PE50 also required a significantly lesser number of rescue mephentermine for hypotension when compared to groups PE25 and C (0.00 v/s 0.18 ± 1.04 v/s 3.13 ± 5.31, P < 0.001). No significant difference was observed in number of patients experiencing IONV between the three groups (32% in PE50, 23% in PE25, 9% in C). Conclusion: Infusion of 50 microgram/min phenylephrine is superior to 25 microgram/min infusion and placebo to control IONV with significantly reduced cumulative rescue vasopressor consumption in patients undergoing elective cesarean section under subarachnoid block (SAB).
背景和目的:低血压是产科脊髓麻醉后的常见现象。产妇低血压反过来导致术中恶心和/或呕吐(IONV)。我们拟比较25 μg/min和50 μg/min输注苯肾上腺素对选择性下段剖宫产术患者预防IONV的效果。材料与方法:本前瞻性双盲随机安慰剂对照试验对195例单胎妊娠孕妇进行蛛网膜下腔阻滞下择期剖宫产术。将产妇随机分为C组、P25组、P50组,分别给予生理盐水15 ml/h、100 μg/ml苯肾上腺素15 ml/h(剂量25 μg/min)、200 μg/ml苯肾上腺素15 ml/h(剂量50 μg/min)。比较各组IONV的发生率、抢救用甲氧芬的用量、血流动力学参数、新生儿结局和不良反应。分类资料以数字表示,比较采用卡方检验。连续变量以均数±标准差表示,采用t检验或方差分析进行比较。P < 0.05为差异有统计学意义。结果:PE50组的IONV发作次数明显少于PE25组和C组(分别为0.09±0.29次vs 0.23±0.42次和0.55±0.84次);P < 0.05)。与PE25组和C组相比,PE50组对低血压所需的甲非特明抢救次数也明显减少(0.00 v/s 0.18±1.04 v/s 3.13±5.31,P < 0.001)。三组之间发生IONV的患者数量无显著差异(PE50组32%,PE25组23%,C组9%)。结论:在控制IONV方面,输注50微克/分钟的苯肾上腺素优于输注25微克/分钟和安慰剂,可显著降低蛛网膜下腔阻滞(SAB)下择期剖宫产患者的累积救助性血管加压素消耗。
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引用次数: 0
Evaluation of perfusion index as a screening tool for prediction of hypotension and shivering in cesarean section 剖宫产术中灌注指数作为预测低血压和寒战的筛选工具的评价
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_76_22
Parita Gandhi, Divya Kheskani, H. Chhanwal, Rekha Solanki, M. Shah, Aayushi Singh
Aim: The aim of this study was to determine whether a baseline perfusion index (PI) can predict hypotension and shivering after spinal anesthesia for cesarean section. Materials and Methods: In this prospective, observational study, 100 parturients were divided into two groups on the basis of baseline PI. Group I included parturients with PI of <3.5, and Group II included parturients with PI values ≥3.5. Spinal anesthesia was performed with hyperbaric 2 ml of 0.75% ropivacaine at L3–L4 or L2–L3 interspace. Hypotension was defined as mean arterial pressure <65 mmHg. PI and blood pressure were monitored at baseline, every 2 min for 12 min, and every 10 min until 120 min. Shivering was observed until 120 min according to the Crossley and Mahajan scale. Statistical analysis was performed using Chi-square test, independent sample t-test, and Mann–Whitney U-test. Results: Baseline PI significantly correlated with the number of episodes of hypotension. The overall incidence of hypotension was significantly higher in parturients with baseline PI ≥3.5 (79.16%) compared to those with PI <3.5 (33.33%), and parturients with preoperative PI <3.5 had a greater risk of post-anesthetic shivering. Conclusions: Perfusion Index serves as an excellent tool for predicting hypotension and shivering in pregnant patients.
目的:本研究的目的是确定基线灌注指数(PI)是否可以预测剖宫产腰麻后的低血压和颤抖。材料和方法:在这项前瞻性、观察性研究中,100名产妇根据基线PI分为两组。I组包括PI<3.5的产妇,II组包括PI值≥3.5的产妇。在L3–L4或L2–L3间隙使用2 ml 0.75%罗哌卡因进行脊柱麻醉。低血压定义为平均动脉压<65毫米汞柱。根据Crossley和Mahajan量表,在基线时监测PI和血压,每2分钟监测12分钟,每10分钟监测一次,直到120分钟。使用卡方检验、独立样本t检验和Mann-Whitney U检验进行统计分析。结果:基线PI与低血压发作次数显著相关。与PI<3.5的产妇(33.33%)相比,基线PI≥3.5的产妇低血压的总发生率显著更高(79.16%),术前PI<3.5产妇发生麻醉后颤抖的风险更大。结论:灌注指数可作为预测妊娠期低血压和颤抖的良好工具。
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引用次数: 0
Spinal Anesthesia for a Rh Isommunized Pregnancy with Autologous Blood Transfusion: A Case Report Rh同种异体妊娠自体输血脊髓麻醉1例
Pub Date : 2023-07-01 DOI: 10.4103/JOACC.JOACC_2_23
Pragya Kaur, Yudhyavir Singh, Amit Kumar, Nivedha Giridharan
Autologous blood transfusion is defined as the collection of blood from the patient, either preoperatively or intraoperatively, and its transfusion back to the same patient as and when required. We report a case of a 23-year-old pregnant female, G3P1L1A1, presenting with severe Rh alloimmunization, along with a baby requiring intrauterine transfusion for fetal anemia, planned for elective cesarean section and autologous blood transfusion.
自体输血是指在术前或术中从患者身上采集血液,并在需要时输回同一患者。我们报告了一例23岁的孕妇G3P1L1A1,表现为严重的Rh同种异体免疫,以及一名因胎儿贫血需要宫内输血的婴儿,计划进行选择性剖宫产和自体输血。
{"title":"Spinal Anesthesia for a Rh Isommunized Pregnancy with Autologous Blood Transfusion: A Case Report","authors":"Pragya Kaur, Yudhyavir Singh, Amit Kumar, Nivedha Giridharan","doi":"10.4103/JOACC.JOACC_2_23","DOIUrl":"https://doi.org/10.4103/JOACC.JOACC_2_23","url":null,"abstract":"Autologous blood transfusion is defined as the collection of blood from the patient, either preoperatively or intraoperatively, and its transfusion back to the same patient as and when required. We report a case of a 23-year-old pregnant female, G3P1L1A1, presenting with severe Rh alloimmunization, along with a baby requiring intrauterine transfusion for fetal anemia, planned for elective cesarean section and autologous blood transfusion.","PeriodicalId":16611,"journal":{"name":"Journal of Obstetric Anaesthesia and Critical Care","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49082786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Obstetric Anaesthesia and Critical Care
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