糖尿病侵袭性感染的治疗:综述

Anjum Khanam, G. Hithamani, J. Naveen, S. R. Pradeep, Susmita Barman, K. Srinivasan
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引用次数: 3

摘要

糖尿病患者通常有更多的侵袭性感染,这可能导致发病率增加。高血糖环境会促进免疫功能障碍(如中性粒细胞活性下降、抗氧化系统抑制和先天免疫受损)、微血管病和神经病变。更多的医疗干预会导致糖尿病患者感染的频率更高。糖尿病患者易患某些疾病,如鼻脑毛霉菌病或曲霉菌病感染。感染可能是糖尿病的主要症状,也可能是该疾病内在影响的诱因,如糖尿病酮症酸中毒和低血糖,此外还会增加发病率。对感染的严重程度和起源进行彻底诊断是有效治疗的必要条件,这通常需要手术和广泛使用抗生素。研究糖尿病患者的重大感染问题至关重要。全面的研究应该研究为什么感染在糖尿病患者中更常见,以及预防性治疗策略可能是什么。
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Management of Invasive Infections in Diabetes Mellitus: A Comprehensive Review
Patients with diabetes often have more invasive infections, which may lead to an increase in morbidity. The hyperglycaemic environment promotes immune dysfunction (such as the deterioration of neutrophil activity, antioxidant system suppression, and compromised innate immunity), micro- and microangiopathies, and neuropathy. A greater number of medical interventions leads to a higher frequency of infections in diabetic patients. Diabetic individuals are susceptible to certain conditions, such as rhino-cerebral mucormycosis or aspergillosis infection. Infections may either be the primary symptom of diabetes mellitus or act as triggers in the intrinsic effects of the disease, such as diabetic ketoacidosis and hypoglycaemia, in addition to increasing morbidity. A thorough diagnosis of the severity and origin of the infection is necessary for effective treatment, which often entails surgery and extensive antibiotic use. Examining the significant issue of infection in individuals with diabetes is crucial. Comprehensive research should examine why infections are more common amongst diabetics and what the preventive treatment strategies could be.
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