肝缺血再灌注损伤干预措施研究进展

Q4 Medicine 中华肝胆外科杂志 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.11.020

Zhongshan Lu, Wei Wang, Z. Zhong, Q. Ye, G. Peng

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引用次数: 0

摘要

肝缺血再灌注损伤是肝移植过程中不可避免的临床现象。肝缺血再灌注损伤的机制是复杂的，涉及活性氧、炎症因子、钙超载、中性粒细胞和库普弗细胞。如果损伤继续恶化，肝细胞将发生坏死、凋亡和自噬。近年来，肝缺血再灌注损伤的干预措施主要包括缺血预处理、药物预处理、化学预处理、亚低温预处理以及机器灌注和基因靶向治疗。随着损伤机制研究的深入，新的干预方法不断涌现，将为肝脏缺血再灌注损伤的临床防治带来新的思路。关键词：肝；再灌注损伤；干预

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Advances in intervention measures for hepatic ischemia-reperfusion injury

Hepatic ischemia-reperfusion injury is an inevitable clinical phenomenon during the liver transplantation. The mechanism of hepatic ischemia-reperfusion injury is complex, with reactive oxygen species, inflammatory factors, calcium overload, neutrophils and Kupffer cells involved. If injury continues to getting worsen, liver cells will undergo necrosis, apoptosis, and autophagy. Interventions for hepatic ischemia-reperfusion injury mainly include ischemic preconditioning, drug pretreatment, chemical pretreatment, mild hypothermia pretreatment, and machine perfusion and gene-targeted therapy in recent years. With the indepth research of injury mechanism, new intervention methods continue to emerge, which will bring new ideas for clinical prevention and treatment of liver ischemia-reperfusion injury. Key words: Liver; Reperfusion injury; Intervention

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.