Siddha制剂Lavana Dravagam在大鼠模型中的药理活性评价

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL BioMedicine-Taiwan Pub Date : 2023-07-20 DOI:10.51248/.v43i3.2135
Jeeva S., Kesavarajan S., M. A, S. S, Meenakaumari R., R. Sudalaimani
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引用次数: 0

摘要

引言和目的:贫血是所有年龄段人群中最常见的缺陷性疾病,在悉达医学体系中被称为Paandu。siddha文献kannukamiyam ennum vaithiya segaram中提到的试验药物siddha多矿物制剂Lavana Dravagam已用于治疗贫血。Dravagam是一种通过蒸馏法加工的内科药物,也被称为Pugai neer、Shakthi neer、Dravaga neer。本研究旨在评估多矿物Siddha制剂Lavana Dravagam对苯肼诱导的贫血白化Wistar大鼠模型的血液活性和疗效。材料和方法:将动物分为四组(I、II、III和IV),每组6只大鼠(n=6)。通过口服苯肼(每次口服10mg/kg的单次剂量,持续8天)诱导贫血。第一组作为正常对照,第二组以2mL/kg的剂量接受悬浮液形式的标准药物血红素糖浆。第III组、第IV组分别以0.02毫升至0.03毫升/公斤的剂量接受Lavana Dravagam的配方口服独立混合物。红细胞、血红蛋白、PCV、MCV、MCH作为贫血指标进行分析。计算平均红细胞体积、平均红细胞血红蛋白和平均红细胞Hb浓度。结果:从文献资料、急性毒性评价和药理研究等方面证实,该药具有止血活性。本研究表明,在治疗一周内给予苯肼后,红细胞计数、Hb水平和PCV显著增加(P<0.05)。结论:本品治疗贫血(Paandu)效果良好。
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Pharmacological evaluation for haematinic activity of Siddha formulation Lavana Dravagam in rat model
Introduction and Aim:  Anaemia is the most common deficiency disorder among people of all age groups, known as Paandu in the Siddha system of medicine. The test drug siddha poly mineral formulation Lavana Dravagam mentioned in Siddha literature kannukamiyam ennum vaithiya segaram, has been used for pandu (anaemia). Dravagam is a form of internal medicine, processed by distillation method and is also referred as Pugai neer, Shakthi neer, Dravaga neer. The study aimed to evaluate the haematinic activity and efficacy of poly mineral Siddha formulation Lavana Dravagam against phenylhydrazine induced anaemic albino Wistar rat model.   Materials and Methods:  The animals were selected and divided into four groups (I, II, III, and IV) of six rats (n=6) each. Anaemia was induced by an oral administration of phenylhydrazine (single dose of 10 mg/kg per oral for 8 days). Group I served as normal control and Group II received standard drug hematinic syrup in suspension form at dose 2 mL/kg. Groups III, IV received the formulated oral indiffusible mixture of Lavana Dravagam at a dose of 0.02ml to 0.03ml/kg respectively. RBC, Hb, PCV, MCV, MCH, were analyzed as indices of anaemia. The mean corpuscular volume, mean corpuscular Hb, and mean corpuscular Hb concentration were calculated.   Results: From the literature evidence, acute toxicity evaluation and pharmacological studies, the drug Lavana Dravagam is found out to have hematinic activity. This study reveals that there is significant (P<0.05) increase in RBC count, Hb level, and PCV by administering phenylhydrazine within one week of treatment.   Conclusion: It could be concluded that the drug Lavana dravagam will have promising effects in the management of anaemia (Paandu).
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来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
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