利用生物信息学工具鉴定乳糜泻和克罗恩病之间的枢纽基因和关键途径

IF 0.2 Q4 CHEMISTRY, MULTIDISCIPLINARY Periodico Tche Quimica Pub Date : 2022-07-31 DOI:10.52571/ptq.v19.n41.2022.04_gul_pgs_35_47.pdf
Gül Kozalak, Nazente Atçeken, R. Ozgul
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引用次数: 0

摘要

背景:慢性炎症性疾病是机体对任何刺激的长期反应。克罗恩病(CD)和腹腔炎(CeD)属于慢性炎症性疾病,两者都会导致肠道慢性炎症。这两种疾病都是由多基因、环境和生活方式的风险因素引起的。炎症会使疾病长期存在,并使其成为慢性病。因此,选择肠道作为靶器官的CD和CeD可能会相互触发。尽管这些疾病之间的关系在文献中被广泛提及,但对这些炎症性疾病的免疫机制却知之甚少。目的:本研究旨在确定CD和CeD之间共享的枢纽基因、转录因子miRNA和蛋白质化学相互作用网络。方法:下载NCBI-GEO数据集并在GEO2R中进行分析,以鉴定差异表达基因(DEGs)。蛋白质-蛋白质相互作用的STRING工具(PPI)和NetworkAnalyst工具用于基因集富集分析(GSEA)、转录因子(TF)-miRNA协同调节网络和蛋白质化学相互作用。结果与讨论:GSE11501和GSE3365数据集用于识别CD和CeD中的54个DEG。这些常见表达的基因中有13个被定义为枢纽基因。GSEA表明,这些基因与免疫系统过程、细胞防御反应、蛋白水解和细胞凋亡有关。KAT6A和SPI1是指导肠上皮细胞连续性的转录因子。抗风湿药和甲氨蝶呤可能用于治疗这些疾病。结论:表位扩散引起的迟发型超敏反应是CD和CeD共同的免疫机制。鉴于CD和CeD在人群中的患病率越来越高,显然需要更多的研究来了解这些疾病的共同发病机制和重叠的免疫机制。
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IDENTIFICATION OF HUB GENES AND KEY PATHWAYS BETWEEN CELIAC AND CROHN'S DISEASES VIA BIOINFORMATICS TOOLS
Background: Chronic inflammatory diseases are the long-term response of the organism to any stimulus. Crohn's (CD) and Celiac (CeD) diseases are among chronic inflammatory diseases, and both cause chronic inflammation in the intestines. Both diseases are caused by polygenic, environmental, and lifestyle risk factors. Inflammation can perpetuate disease and cause it to become chronic. For this reason, CD and CeD that choose the intestine as the target organ may trigger each other. Although the relationship between these diseases is widely mentioned in the literature, scanty knowledge and research have been done on the immune mechanisms of these inflammatory diseases. Aim: This study aimed to determine hub genes, transcription factors-miRNAs, and protein-chemical interaction networks shared between CD and CeD. Methods: The NCBI-GEO datasets were downloaded and analyzed in GEO2R to identify differentially expressed genes (DEGs). STRING tool for Protein-Protein Interaction (PPI) and NetworkAnalyst tool were used for Gene Set Enrichment Analysis (GSEA), Transcription factor (TF) - miRNA Coregulatory Networks, and Protein-Chemical Interactions. Results and Discussion: GSE11501 and GSE3365 datasets were utilized to recognize 54 DEGs in CD, and CeD. 13 of these commonly expressed genes were defined as hub genes. GSEA has indicated that these genes are associated with immune system processes, cellular defense response, proteolysis, and apoptosis. KAT6A and SPI1 are transcription factors that direct the continuity of intestinal epithelial cells. Antirheumatic agents and Methotrexate are likely to be used to treat these diseases. Conclusions: In conclusion, we think that delayed-type hypersensitivity resulting from epitope propagation is a common immune mechanism of CD and CeD. Given the increasing prevalence of both CD and CeD in the population, it is clear that more studies are needed to understand the shared pathogenesis and overlapping immune mechanisms of these diseases.
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Periodico Tche Quimica
Periodico Tche Quimica CHEMISTRY, MULTIDISCIPLINARY-
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期刊介绍: The Journal publishes original research papers, review articles, short communications (scientific publications), book reviews, forum articles, announcements or letters as well as interviews. Researchers from all countries are invited to publish on its pages.
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