Origami-Induced Alignment of MNP Inside of DNA Nanotubes

Background: The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different types of nanomaterial, can be the suitable candidate for template patterning alignment and precise organization of nanoparticles at surface or into channel. These characteristics can be used in nanoelectronic devise or in the field of diagnostic nanobiosensores. Methods: Here, we report a new construction methodology for encapsulation of magnetic nanoparticles inside DNA nanotubes channel. Constructed-simultaneously encapsulation of magnetic nanoparticles into the large channel of this tubes leads to “pea-pod” particle alignment in nanotube channel. Results: Transmission electron microscopy and atomic force microscopy confirmed the fabrication of DNA nanotubes contained the magnetic nanoparticles inside the channel. Conclusion: These biohybrid nanomaterial would be proposed as the nanoarray platform in nanobiosensing devices.