Pub Date : 2023-01-01DOI: 10.23937/2378-3664.1410038
Liu Zhanao, Tian Ailing, Yi Xin, Sun Nianfeng, Di Yong
{"title":"Study of Mesenchymal Stem Cell in Combination with Self-Assembled Functional Nanopeptide Gel to Promote Angiogenesis","authors":"Liu Zhanao, Tian Ailing, Yi Xin, Sun Nianfeng, Di Yong","doi":"10.23937/2378-3664.1410038","DOIUrl":"https://doi.org/10.23937/2378-3664.1410038","url":null,"abstract":"","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68748669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.23937/2378-3664.1410039
Sheng Wang
{"title":"Possible Effect of Nano Characterization of COVID-19 on Infection and Causing Disease","authors":"Sheng Wang","doi":"10.23937/2378-3664.1410039","DOIUrl":"https://doi.org/10.23937/2378-3664.1410039","url":null,"abstract":"","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68748679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.23937/2378-3664.1410037
M. Pooja, Irum Irum, Hussain Akhtar, B. Abu
{"title":"Therapeutic Application of Nanomaterials in the Management of Health Care: 'An Updated Review'","authors":"M. Pooja, Irum Irum, Hussain Akhtar, B. Abu","doi":"10.23937/2378-3664.1410037","DOIUrl":"https://doi.org/10.23937/2378-3664.1410037","url":null,"abstract":"","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44427447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.23937/2378-3664.1410036
P. Sandhya, Tripathi Satyendra Kumar, Pachouri Chandni, P. Archna
Osteoporosis means "Porous bone” is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India. Alendronate (Aln) is a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclast cells. Alendronate-sodium is a BCS class III bisphosphonate, used in the treatment of osteoporosis, acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Alendronate was the first bisphosphonate to be approved for osteoporosis in the US in 1995. The objective of the present study is to develop, optimize, and evaluate Alendronate-loaded chitosan nanoparticles (NPs) for the treatment of osteoporosis. NPs were prepared by the Ionic gelation method and optimized for various parameters. The prepared nanoparticles were characterized using particle size analyser (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and fourier-transform infrared spectroscopy (FTIR). Formulated NPs were obtained in the average size ranging from 60 nm to 220 nm in TEM, SEM and DLS studies. The release profile was depended on the dissolution medium. The proposed nanoparticles offer an interesting alternative for alendronate delivery via the oral route. Our results indicated that alendronate-loaded chitosan nanoparticles provide an effective medication for the treatment of osteoporosis.
{"title":"Encapsulation of Alendronate in Chitosan based Polymeric Nanoparticles for Effective Management of Osteoporosis – Development to Release Kinetic Study","authors":"P. Sandhya, Tripathi Satyendra Kumar, Pachouri Chandni, P. Archna","doi":"10.23937/2378-3664.1410036","DOIUrl":"https://doi.org/10.23937/2378-3664.1410036","url":null,"abstract":"Osteoporosis means \"Porous bone” is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India. Alendronate (Aln) is a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclast cells. Alendronate-sodium is a BCS class III bisphosphonate, used in the treatment of osteoporosis, acts as a potent, specific inhibitor of osteoclast-mediated bone resorption. Alendronate was the first bisphosphonate to be approved for osteoporosis in the US in 1995. The objective of the present study is to develop, optimize, and evaluate Alendronate-loaded chitosan nanoparticles (NPs) for the treatment of osteoporosis. NPs were prepared by the Ionic gelation method and optimized for various parameters. The prepared nanoparticles were characterized using particle size analyser (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and fourier-transform infrared spectroscopy (FTIR). Formulated NPs were obtained in the average size ranging from 60 nm to 220 nm in TEM, SEM and DLS studies. The release profile was depended on the dissolution medium. The proposed nanoparticles offer an interesting alternative for alendronate delivery via the oral route. Our results indicated that alendronate-loaded chitosan nanoparticles provide an effective medication for the treatment of osteoporosis.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48331714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.23937/2378-3664.1410035
Pachouri Chandni, P. Bharat, Shroti Sandhya, S. Sandeep, P. Archna
Current treatment therapeutic approach for tuberculosis is the administration of first line drugs in the form of tablets and capsules for 4-6 months however; this approach leads to sever adverse effect. Therefore, present study was designed to achieving local and sustained targeting of ant tuberculosis drugs in order to reduce dose n frequency. Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Nanoparticles of antituberculosis drugs are generally prepared by using chitosan and PLGA polymer. Nanoparticles of Chitosan being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. The selection of a nanoencapsulation technique should consider drug property, nanoparticle quality, scale-up feasibility, manufacturing costs, personnel safety, environmental impact, waste disposal, and the like. In recent years, there have been a plethora of nanoengineering approaches for the development of poly (lactide-co-glycolide) (PLGA) nanoparticulate carrier systems. However, overlooking the multifaceted issues in the preparation and characterization of PLGA-based nanoparticles. Relevant information might be helpful to those who prepare and develop nanoparticles of ant tuberculosis drugs that meet their specific demands.
{"title":"Recent Trends in Nanoparticles Based Drug Delivery for Tuberculosis Treatment","authors":"Pachouri Chandni, P. Bharat, Shroti Sandhya, S. Sandeep, P. Archna","doi":"10.23937/2378-3664.1410035","DOIUrl":"https://doi.org/10.23937/2378-3664.1410035","url":null,"abstract":"Current treatment therapeutic approach for tuberculosis is the administration of first line drugs in the form of tablets and capsules for 4-6 months however; this approach leads to sever adverse effect. Therefore, present study was designed to achieving local and sustained targeting of ant tuberculosis drugs in order to reduce dose n frequency. Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Nanoparticles of antituberculosis drugs are generally prepared by using chitosan and PLGA polymer. Nanoparticles of Chitosan being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. The selection of a nanoencapsulation technique should consider drug property, nanoparticle quality, scale-up feasibility, manufacturing costs, personnel safety, environmental impact, waste disposal, and the like. In recent years, there have been a plethora of nanoengineering approaches for the development of poly (lactide-co-glycolide) (PLGA) nanoparticulate carrier systems. However, overlooking the multifaceted issues in the preparation and characterization of PLGA-based nanoparticles. Relevant information might be helpful to those who prepare and develop nanoparticles of ant tuberculosis drugs that meet their specific demands.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41749734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-09DOI: 10.23937/2378-3664.1410034
S. V, K. S, I. R, R. S
The regeneration of soft tissue is challenging task in the medicine due to infection at the wound site. Therefore, it requires a rapid regeneration scaffold for dermis and epidermis in the soft tissue. The silver nanoparticles (AgNPs) impregnated nanocollagen has been developed for soft tissue repair. The nano-collagen contained silver nanoparticles facilitates the rapid regeneration of wounded skin, when compared to collagen microfibers. Collagen was extracted from scales of Catla fish and made into nanocollagen using a standard ultrasonic processing method. The average diameter of collagen nanofibres after sonication process was evaluated to be 500 nm. The collagen fibres are aggregated due to hydrogen bonding between amino acids in the side chain. Size of silver nanoparticles to be impregnated into the nanocollegen varied from 180 to 210 nm. The nanocollagen with AgNPs, were characterized using UV-Vis spectroscopy, SDS PAGE, particle size analyzer, Transmission Electron Microscopy (TEM) and Fourier Transform Infrared spectroscopy (FTIR). The UV-Visible spectroscopy investigated the genesis of spherical shaped silver nanoparticles through surface plasmon band between 250 to 300 nm. The formation of silver nanoparticles was confirmed by wavelength of 300 nm under UV region. The silver nanoparticles have a good antibacterial action against wound pathogens. Nanocollagen with silver nanoparticles were subjected to MTT cytotoxicity assay under optimized concentration and in vitro wound healing assay was also performed on EA.hy926 cell lines, to evaluate efficacy of this nanomaterial scaffold for wound repair. This study confirmed that silver nanoparticles impregnated nanocollagen could be a potential wound repair biomedical scaffold.
{"title":"Silver Nanoparticles Impregnated Nanocollagen as Scaffold for Soft Tissue Repair-Synthesis, Characterization, and In vitro Investigation","authors":"S. V, K. S, I. R, R. S","doi":"10.23937/2378-3664.1410034","DOIUrl":"https://doi.org/10.23937/2378-3664.1410034","url":null,"abstract":"The regeneration of soft tissue is challenging task in the medicine due to infection at the wound site. Therefore, it requires a rapid regeneration scaffold for dermis and epidermis in the soft tissue. The silver nanoparticles (AgNPs) impregnated nanocollagen has been developed for soft tissue repair. The nano-collagen contained silver nanoparticles facilitates the rapid regeneration of wounded skin, when compared to collagen microfibers. Collagen was extracted from scales of Catla fish and made into nanocollagen using a standard ultrasonic processing method. The average diameter of collagen nanofibres after sonication process was evaluated to be 500 nm. The collagen fibres are aggregated due to hydrogen bonding between amino acids in the side chain. Size of silver nanoparticles to be impregnated into the nanocollegen varied from 180 to 210 nm. The nanocollagen with AgNPs, were characterized using UV-Vis spectroscopy, SDS PAGE, particle size analyzer, Transmission Electron Microscopy (TEM) and Fourier Transform Infrared spectroscopy (FTIR). The UV-Visible spectroscopy investigated the genesis of spherical shaped silver nanoparticles through surface plasmon band between 250 to 300 nm. The formation of silver nanoparticles was confirmed by wavelength of 300 nm under UV region. The silver nanoparticles have a good antibacterial action against wound pathogens. Nanocollagen with silver nanoparticles were subjected to MTT cytotoxicity assay under optimized concentration and in vitro wound healing assay was also performed on EA.hy926 cell lines, to evaluate efficacy of this nanomaterial scaffold for wound repair. This study confirmed that silver nanoparticles impregnated nanocollagen could be a potential wound repair biomedical scaffold.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46373032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-09DOI: 10.23937/2378-3664.1410033
L. Santhana Raj, MA Nur Dayana, SN Norzarila, C. Tan, MH Nur Afrina
{"title":"New Preparation Method of Reynolds' Stain for Transmission Electron Microscope for Liver Samples","authors":"L. Santhana Raj, MA Nur Dayana, SN Norzarila, C. Tan, MH Nur Afrina","doi":"10.23937/2378-3664.1410033","DOIUrl":"https://doi.org/10.23937/2378-3664.1410033","url":null,"abstract":"","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46527754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-28DOI: 10.23937/2378-3664.1410032
Jawad Akram Jassim
Nowadays, smart home devices have started to take a part in everything in our life, which mainly have been developed to consist from brain computer interface (BCI). In recent months, Neuralink BCI (1024-Electode) has been approved to be used by Food and Drug Administration (FDA) in the USA. That makes the ethical related studies have more attention to apply these devices and technologies in our daily life with more security. In this work, the ethical challenges of smart home systems that use BCI for personal monitoring, such as Neuralink Interfaces, have been reviewed, analysed and discussed regarding the fundamental principles in ‘Statement of Ethical Principles for the Engineering Profession’ of the UK. Firstly, a brief introduction of Neuralink BCI technology and important applications in daily life were discussed with related ethics issues. Then, proposed solutions and recommendations for every situation have been introduced and discussed as well. The main proposed ways to address that are establishing and introducing the related laws and rules, technology development of security and safety, and educate for acceptance culture in the society.
{"title":"Implantations and Applications of Brain Computer Interfaces as Medical Devices: A Short Review of Engineering Ethics","authors":"Jawad Akram Jassim","doi":"10.23937/2378-3664.1410032","DOIUrl":"https://doi.org/10.23937/2378-3664.1410032","url":null,"abstract":"Nowadays, smart home devices have started to take a part in everything in our life, which mainly have been developed to consist from brain computer interface (BCI). In recent months, Neuralink BCI (1024-Electode) has been approved to be used by Food and Drug Administration (FDA) in the USA. That makes the ethical related studies have more attention to apply these devices and technologies in our daily life with more security. In this work, the ethical challenges of smart home systems that use BCI for personal monitoring, such as Neuralink Interfaces, have been reviewed, analysed and discussed regarding the fundamental principles in ‘Statement of Ethical Principles for the Engineering Profession’ of the UK. Firstly, a brief introduction of Neuralink BCI technology and important applications in daily life were discussed with related ethics issues. Then, proposed solutions and recommendations for every situation have been introduced and discussed as well. The main proposed ways to address that are establishing and introducing the related laws and rules, technology development of security and safety, and educate for acceptance culture in the society.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44167536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-20DOI: 10.23937/2378-3664/1410031
Rafati Adele, Zarrabi Ali, Gill Pooria
Background: The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different types of nanomaterial, can be the suitable candidate for template patterning alignment and precise organization of nanoparticles at surface or into channel. These characteristics can be used in nanoelectronic devise or in the field of diagnostic nanobiosensores. Methods: Here, we report a new construction methodology for encapsulation of magnetic nanoparticles inside DNA nanotubes channel. Constructed-simultaneously encapsulation of magnetic nanoparticles into the large channel of this tubes leads to “pea-pod” particle alignment in nanotube channel. Results: Transmission electron microscopy and atomic force microscopy confirmed the fabrication of DNA nanotubes contained the magnetic nanoparticles inside the channel. Conclusion: These biohybrid nanomaterial would be proposed as the nanoarray platform in nanobiosensing devices.
{"title":"Origami-Induced Alignment of MNP Inside of DNA Nanotubes","authors":"Rafati Adele, Zarrabi Ali, Gill Pooria","doi":"10.23937/2378-3664/1410031","DOIUrl":"https://doi.org/10.23937/2378-3664/1410031","url":null,"abstract":"Background: The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different types of nanomaterial, can be the suitable candidate for template patterning alignment and precise organization of nanoparticles at surface or into channel. These characteristics can be used in nanoelectronic devise or in the field of diagnostic nanobiosensores. Methods: Here, we report a new construction methodology for encapsulation of magnetic nanoparticles inside DNA nanotubes channel. Constructed-simultaneously encapsulation of magnetic nanoparticles into the large channel of this tubes leads to “pea-pod” particle alignment in nanotube channel. Results: Transmission electron microscopy and atomic force microscopy confirmed the fabrication of DNA nanotubes contained the magnetic nanoparticles inside the channel. Conclusion: These biohybrid nanomaterial would be proposed as the nanoarray platform in nanobiosensing devices.","PeriodicalId":91094,"journal":{"name":"International journal of medical nano research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42323196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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