三维打印聚己内酯/多组分生物活性玻璃支架在骨组织工程中的潜在应用

Q1 Materials Science Biomedical Glasses Pub Date : 2020-01-01 DOI:10.1515/bglass-2020-0006
A. Fathi, F. Kermani, A. Behnamghader, S. Banijamali, M. Mozafari, F. Baino, S. Kargozar
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引用次数: 19

摘要

在过去的几年里,三维(3D)打印已经成功地应用于制造合适的骨缺损替代物。在这项工作中,3D打印了聚己内酯(PCL)和锶(Sr)和钴(Co)掺杂的多组分熔融衍生生物活性玻璃(BGs)的复合支架,用于骨组织工程策略。为此,将制备好的BG颗粒(尺寸<38 μm)的30%加入到PCL中,然后将得到的复合混合物引入3D打印机,逐层制备尺寸为12 × 12 × 2 mm3的多孔结构。通过一系列的物理化学和生物实验对支架进行了充分的表征。将BGs添加到PCL中,可以改善制备的支架的抗压强度并增加其亲水性。此外,PCL/BG支架在浸泡于模拟体液(SBF)后显示出磷灰石形成能力(即生物活性行为)。体外细胞实验结果表明,该支架具有良好的细胞相容性,是MG-63骨肉瘤细胞粘附和增殖的理想底物。综上所述,3D打印PCL和Sr共掺杂BGs复合支架可能是潜在的有益骨替代物,所取得的结果激励了这些材料的进一步研究。
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Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering
Abstract Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3. The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
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审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
期刊最新文献
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