具有ROS清除能力和促成骨作用的单宁酸修饰的锶掺杂仿生骨片促进骨质疏松性骨愈合

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2023.05.001
Zhenzhen Wu , Le Fan , Cuiting Chen , Yuanyuan Ma , Xiangnan Wu , Ying Li , Zhichao Hao , Tao Yang
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引用次数: 1

摘要

骨质疏松症下的成骨能力受损和活性氧(ROS)的过度积累严重削弱了仿生骨移植的修复性能。目前,仿生骨移植物能够高度模拟骨层次,可以显著促进骨再生,而不会引起全身性疾病。在不影响层次仿生学的情况下,修饰具有生物活性的仿生骨移植物是治疗骨质疏松性骨缺损的可行方法。本文通过锶-无定形磷酸钙矿化脱细胞胶原片层,并用单宁酸(TA)进一步修饰,构建了TA修饰的掺锶仿生骨片层。系统评价其对骨质疏松性骨髓间充质干细胞的理化性质、清除活性氧能力及促骨作用。结果表明,TA和Sr可以在不影响仿生骨片纳米结构和微结构的情况下成功修饰仿生骨片。该构建体不仅能长期有效地清除ROS,还能有效地促进氧化应激环境下骨质疏松性骨髓间充质干细胞的增殖和成骨分化。在骨质疏松大鼠临界尺寸骨缺损中植入后,通过协同激活PI3K/AKT信号通路,有效促进骨再生。因此,该结构有望成为未来具有更复杂层次结构的工程仿生骨移植物的候选材料,以加速骨质疏松性骨缺损的愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Promotion of osteoporotic bone healing by a tannic acid modified strontium-doped biomimetic bone lamella with ROS scavenging capacity and pro-osteogenic effect

The impaired osteogenic ability and excessive accumulation of reactive oxygen species (ROS) under osteoporosis severely weaken repair performance of biomimetic bone grafts. Currently, biomimetic bone grafts, capable of highly simulating bone hierarchy, could remarkably promote bone regeneration without systemic disease. Decorating biomimetic bone grafts with bioactivities without compromising hierarchical biomimicry stands as a feasible approach to treat the osteoporotic bone defect. Herein, through mineralizing decellularized collagen lamellae via strontium (Sr)- amorphous calcium phosphate and further modifying with tannic acid (TA), TA modified Sr-doped biomimetic bone lamellae was engineered. The physicochemical properties, ROS scavenging capacity and pro-osteogenic effect on osteoporotic bone marrow mesenchymal stem cells of construct were systemically evaluated. The results showed that TA and Sr can be successfully decorated without impairing the nano- and micro-architecture of biomimetic bone lamellae. The construct not only exhibited a potent and long-standing performance to eliminate ROS, but also effectively fostered the proliferation and osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells under oxidative stress environment. After implantation in the critical-sized bone defect of osteoporotic rat, it potently facilitated bone regeneration via synergistically activating PI3K/AKT signaling pathway. Hence, this construct is projected to be candidate for further engineering biomimetic bone grafts with more complicated hierarchy for accelerated healing of the osteoporotic bone defect.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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