Susceptibility of the deviants

Genetic variability is essential to occur evolution. The fitness of the organism depends on its capacity to adapt to the changing environmental conditions. Antimicrobial agents exert strong selective pressure on the bacterial population favoring the microorganisms that are capable of resisting them. Genetic variability may occur by variety of the mechanisms such as micro evolutionary changes in the form of point mutations and macro evolutionary changes in the large segment of the DNA which ultimately leads to acquired resistance and better survival of the organisms.1 Intrinsic resistance is also not an exception to this transformation as documented by HHS studies about Burkholderia pseudomallei and other Minimum inhibitory concentration (MIC) studies as well. Though B.pseuodomallei is known for its intrinsic resistance to aminoglycosides and macrolide, found to be susceptible to them due absence of or nonfunctional RND (resistance nodulation division) pumps.