整个月经周期抗髓激素的变化

Ali Falih Al-Assadi, Huda AL.Sharae, Wafaa Sami, Safa Kifah
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摘要

这项前瞻性横断面研究旨在评估患有低生育能力并在巴士拉妇幼医院巴士拉生育中心就诊的女性在整个月经周期中抗苗勒管激素的变化。本研究于2019年2月至2020年7月在巴士拉妇幼医院(伊拉克南部巴士拉市)进行。参与者在研究周期前至少2个月未使用联合口服避孕药(COC)或怀孕或哺乳;通过从平均周期长度中减去14天来确定周期中期。50名参与者参与了这项研究;他们使用专门设计的问卷进行评估。从每次就诊中抽取3份血样进行抗苗勒氏测量,第一份在男性月经周期的卵泡早期,第二份在月经周期中期,第三份在黄体中期。AMH1(卵泡早期)和AMH2(周期中期)之间的差异(p值0.0001)以及AMH2和AMH3(黄体中期)之间(p值0.004),而AMH1和AMH3之间没有统计学上的显著差异。总之,AMH水平存在显著的周期内变化,并且在周期中期趋于较低。该表显示了低、正常和高AMH患者的平均水平变化。在平均AMH值低的患者中,最高值出现在黄体中期,这三者之间的差异具有统计学意义。
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ANTIMULLARIAN HORMONE VARIATION THROUGHOUT THE MENSTRUAL CYCLE
This prospective cross-sectional study is to assess the Anti-Mullerian hormone variation throughout the menstrual cycle in the number of women suffering from subfertility and attending the Basrah Fertility Center at Basrah Mater nity and Children Hospital. This study was conducted at Basrah Maternity and Children Hospital (Basrah city, south of Iraq) during the pe riod from February 2019 to July 2020.The participants had not used combined oral contraceptive (COC) or being pregnant or breastfeeding for at least 2 months before the study cycle; midcycle was identified by subtracting 14 days from the mean cycle length. Fifty participants were included in this study; they were assessed using specially designed questionnaire. From each attendance 3 blood samples were taken for Anti-mullerian measurment, the first at the early follicular phase, the second one at the midcycle, and the third at the mid-luteal phase of the men strual cycle. differences between AMH1 (early follicular phase) and AMH2 (midcycle) (p-value 0.0001) and between AMH2 and AMH3 (mid-luteal phase) (p-value 0.004), whereas there was no statisti cally significant difference between AMH1 and AMH3. In conclusion, there is a significant intracyclic variation in the level of AMH and which tend to be lower at the mid cycle phase. This table shows the variation in the mean level in a with low, normal, and high In a patient with low mean AMH value, the highest value was at the mid-luteal phase, and the was differences these 3 were statistically significant.
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