Adaptive reactivity of cerebral energy metabolism in individuals with vibration disease and diabetes mellitus type 2

Introduction. Knowledge of adaptation options on the example of the reactivity of cerebral energy metabolism (CEM) under stress is important for determining the features of the development of vibration disease in the comorbid course of diabetes mellitus type 2 (DM2), the success of recovery in the rehabilitation period. Objective of the study was adaptation options using the example of cerebral energy metabolism reactivity under stress in individuals with vibration disease caused by the simultaneous effect of local and general vibration (SLGV) and type 2 diabetes mellitus. Materials and methods. Features of adaptation under stress were studied by the method of neuroenergy mapping with the measurement of the level of constant potential (DC-potential level). Groups were formed: I (n = 94) – patients with SLGV, II (n = 38) – with comorbid pathology (SLGV and DM 2), III (n = 39) – with DM2. Results. More than 60% of all examined patients were established to be characterized by a rigid response to physical and emotional stress. Adequate CEM recovery reaction in the posthyperventilation period in the predominant number of cases was observed only in group I. In patients of group II, perverse (39%) and rigid (32%) reactions of recovery of DC-potential level were more common, group III – perverted and excessive response (33 % and 28%, respectively), characterizing the disorder of physiological adaptation in the presence of DM2. Limitations. The limitations of the work are presented in the form of a brief description of working conditions, lack of study of the impact of industrial noise on cerebral hemodynamics, insufficient depth of the study of foreign literature materials on the issue under study. Conclusion. The comorbid course SLGV and DM2 causes a persistent impairment of adaptation to stress, which is confirmed by the rigidity of the DC-potential level in response to hyperventilation, quick verbal response test, and the inadequacy of response during the restoration of neuroenergy exchange in the posthyperventilation period.