巴豆刺叶属新盐烷和氯烷二萜

IF 4.8 3区 化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2023-07-06 DOI:10.1007/s13659-023-00386-z
Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin
{"title":"巴豆刺叶属新盐烷和氯烷二萜","authors":"Xun Wei,&nbsp;Jia-Luo Huang,&nbsp;Hua-Hua Gao,&nbsp;Fang-Yu Yuan,&nbsp;Gui-Hua Tang,&nbsp;Sheng Yin","doi":"10.1007/s13659-023-00386-z","DOIUrl":null,"url":null,"abstract":"<div><p>Three new halimane furanoditerpenoids (<b>1</b>–<b>3</b>) and three new clerodane furanoditerpenoids (<b>4</b>–<b>6</b>), along with seven known terpenoids including four pimarane diterpenoids (<b>7</b>–<b>10</b>) and three norisoprenoids (<b>11</b>–<b>13</b>) were isolated from the 95% EtOH extracts of the plants of <i>Croton cnidophyllus</i>. The 2D structures including absolute configuration of new furanoditerpenoids (<b>1</b>–<b>6</b>) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (<b>8</b> and <b>9</b>) possessed certain inhibitory effects against NO production stimulated by LPS, with IC<sub>50</sub> values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.</p><h3>Graphical Abstract</h3>\n <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\n </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-023-00386-z.pdf","citationCount":"0","resultStr":"{\"title\":\"New halimane and clerodane diterpenoids from Croton cnidophyllus\",\"authors\":\"Xun Wei,&nbsp;Jia-Luo Huang,&nbsp;Hua-Hua Gao,&nbsp;Fang-Yu Yuan,&nbsp;Gui-Hua Tang,&nbsp;Sheng Yin\",\"doi\":\"10.1007/s13659-023-00386-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Three new halimane furanoditerpenoids (<b>1</b>–<b>3</b>) and three new clerodane furanoditerpenoids (<b>4</b>–<b>6</b>), along with seven known terpenoids including four pimarane diterpenoids (<b>7</b>–<b>10</b>) and three norisoprenoids (<b>11</b>–<b>13</b>) were isolated from the 95% EtOH extracts of the plants of <i>Croton cnidophyllus</i>. The 2D structures including absolute configuration of new furanoditerpenoids (<b>1</b>–<b>6</b>) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (<b>8</b> and <b>9</b>) possessed certain inhibitory effects against NO production stimulated by LPS, with IC<sub>50</sub> values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.</p><h3>Graphical Abstract</h3>\\n <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\\n </div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2023-07-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13659-023-00386-z.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-023-00386-z\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-023-00386-z","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

摘要

从巴豆95% EtOH提取物中分离得到3个新的卤烷类呋喃二萜(1-3)和3个新的氯烷类呋喃二萜(4-6),以及4个已知的海玛烷类二萜(7-10)和3个异戊二萜(11-13)。通过对新呋喃二萜(1-6)的HRMS和NMR数据的分析,以及实验和计算ECD曲线的比较,确定了它们的二维结构,包括绝对构型。生物实验结果表明,化合物8和9对LPS刺激NO生成具有一定的抑制作用,IC50值分别为19.00±1.76 μM和21.61±1.11 μM。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
New halimane and clerodane diterpenoids from Croton cnidophyllus

Three new halimane furanoditerpenoids (13) and three new clerodane furanoditerpenoids (46), along with seven known terpenoids including four pimarane diterpenoids (710) and three norisoprenoids (1113) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (16) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC50 values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.

Graphical Abstract

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Natural Products and Bioprospecting
Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-
CiteScore
8.30
自引率
2.10%
发文量
39
审稿时长
13 weeks
期刊最新文献
Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L. Paeoniflorin mitigates insulin-like growth factor 1-induced lipogenesis and inflammation in human sebocytes by inhibiting the PI3K/Akt/FoxO1 and JAK2/STAT3 signaling pathways Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1